ES8106491A1 - Un procedimiento para preparar derivados de metilencicloami-na - Google Patents

Un procedimiento para preparar derivados de metilencicloami-na

Info

Publication number
ES8106491A1
ES8106491A1 ES493498A ES493498A ES8106491A1 ES 8106491 A1 ES8106491 A1 ES 8106491A1 ES 493498 A ES493498 A ES 493498A ES 493498 A ES493498 A ES 493498A ES 8106491 A1 ES8106491 A1 ES 8106491A1
Authority
ES
Spain
Prior art keywords
isopropyl
alpha
methyleneazetidine
cycloamines
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493498A
Other languages
English (en)
Other versions
ES493498A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES493498A0 publication Critical patent/ES493498A0/es
Publication of ES8106491A1 publication Critical patent/ES8106491A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE METILENCICLOAMINA. CONSTA DE LAS SIGUIENTES ETAPAS: 1. REACCION DE UN COMPUESTO DE ACETAMIDA SUSTITUIDA CON BROMO Y UN ALCOXIDO DE METAL ALCALINO; SE OBTIENE UN INTERMEDIO DE CARBAMATO. 2. CALENTAMIENTO DE ESE COMPUESTO INTERMEDIO CON UN MEDIO ACIDO, CON LO QUE SE OBTIENE UN DERIVADO DE METILENCICLOAMIDA DE FORMULA GENERAL (I). EL ALCOXIDO ES UN METORIDO DE SODIO O DE POTASIO. LA TEMPERATURA DE REACCION DE LA ETAPA PRIMERA OSCILA ENTRE 0 Y 50 GC, MIENTRAS QUE LA CONCENTRACION DE ACIDO DE LA SEGUNDA ETAPA ES AL MENOS 1 NORMAL Y ES PROPORCIONADA POR UN ACIDO MINERAL. *FORMULA*
ES493498A 1979-07-19 1980-07-18 Un procedimiento para preparar derivados de metilencicloami-na Expired ES8106491A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/059,092 US4242261A (en) 1979-07-19 1979-07-19 Production of methylene-cycloamines

Publications (2)

Publication Number Publication Date
ES493498A0 ES493498A0 (es) 1981-07-01
ES8106491A1 true ES8106491A1 (es) 1981-07-01

Family

ID=22020801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493498A Expired ES8106491A1 (es) 1979-07-19 1980-07-18 Un procedimiento para preparar derivados de metilencicloami-na

Country Status (21)

Country Link
US (1) US4242261A (es)
JP (1) JPS5625153A (es)
KR (1) KR840002233B1 (es)
AU (1) AU538138B2 (es)
CA (1) CA1128939A (es)
CH (1) CH646954A5 (es)
DE (1) DE3027168A1 (es)
EG (1) EG14720A (es)
ES (1) ES8106491A1 (es)
FR (1) FR2461703A1 (es)
GB (1) GB2058049B (es)
HK (1) HK385A (es)
IE (1) IE49945B1 (es)
IL (1) IL60375A (es)
IT (1) IT1141609B (es)
NL (1) NL8004165A (es)
PH (1) PH15057A (es)
PT (1) PT71581A (es)
SE (1) SE448993B (es)
SG (1) SG26284G (es)
ZA (1) ZA803778B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
US4652559A (en) * 1982-08-16 1987-03-24 The Upjohn Company 2-(Phenylmethylene)cycloalkyl-azetidines
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
IL141769A0 (en) 1998-09-11 2002-03-10 Aventis Pharma Sa Azetidine derivatives, preparation and medicines containing them
FR2783246B1 (fr) * 1998-09-11 2000-11-17 Aventis Pharma Sa Derives d'azetidine, leur preparation et les medicaments les contenant
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
FR2805817B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
US6566356B2 (en) 2000-03-03 2003-05-20 Aventis Pharma S.A. Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
FR2805810B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation
WO2005000809A1 (en) * 2003-06-11 2005-01-06 Merck & Co., Inc. Substituted 3-alkyl and 3-alkenyl azetidine derivatives
US7906652B2 (en) * 2005-11-28 2011-03-15 Merck Sharp & Dohme Corp. Heterocycle-substituted 3-alkyl azetidine derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130532C (es) * 1961-02-09
US3192206A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-aminoalkyl)-3, 3-disubstitutedn-hydrocarbon-2-pyrrolidinones and corresponding-2-thionpyrrolidinones
US3192210A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones
US3192221A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones and production thereof
US3458635A (en) * 1966-08-08 1969-07-29 Robins Co Inc A H Compositions containing 3-di-substituted methylene pyrrolidines and methods of treating depression
US3732247A (en) * 1970-08-14 1973-05-08 Robins Co Inc A H 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms
US4002766A (en) * 1974-12-26 1977-01-11 A. H. Robins Company, Incorporated Antiarrhythmia methods
US4133881A (en) * 1977-04-27 1979-01-09 A. H. Robins Company, Incorporated Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods

Also Published As

Publication number Publication date
JPS643186B2 (es) 1989-01-19
AU538138B2 (en) 1984-08-02
IL60375A0 (en) 1980-09-16
KR840002233B1 (ko) 1984-12-06
EG14720A (en) 1986-03-31
SE8005235L (sv) 1981-01-20
PH15057A (en) 1982-06-03
GB2058049A (en) 1981-04-08
IT1141609B (it) 1986-10-01
GB2058049B (en) 1983-09-07
JPS5625153A (en) 1981-03-10
FR2461703A1 (fr) 1981-02-06
SE448993B (sv) 1987-03-30
IL60375A (en) 1983-07-31
IE49945B1 (en) 1986-01-08
US4242261A (en) 1980-12-30
ZA803778B (en) 1981-09-30
PT71581A (en) 1980-08-01
KR830003417A (ko) 1983-06-20
DE3027168A1 (de) 1981-02-12
DE3027168C2 (es) 1990-07-05
CA1128939A (en) 1982-08-03
ES493498A0 (es) 1981-07-01
NL8004165A (nl) 1981-01-21
HK385A (en) 1985-01-11
FR2461703B1 (es) 1983-04-22
IT8068156A0 (it) 1980-07-18
CH646954A5 (fr) 1984-12-28
SG26284G (en) 1985-03-08
IE801488L (en) 1981-01-19
AU6061780A (en) 1981-01-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603