ES8103026A1 - Un procedimiento para la preparacion de un peptido - Google Patents

Un procedimiento para la preparacion de un peptido

Info

Publication number
ES8103026A1
ES8103026A1 ES489521A ES489521A ES8103026A1 ES 8103026 A1 ES8103026 A1 ES 8103026A1 ES 489521 A ES489521 A ES 489521A ES 489521 A ES489521 A ES 489521A ES 8103026 A1 ES8103026 A1 ES 8103026A1
Authority
ES
Spain
Prior art keywords
peptides
activity
ubiquitin
lys
therapeutic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489521A
Other languages
English (en)
Other versions
ES489521A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES8103026A1 publication Critical patent/ES8103026A1/es
Publication of ES489521A0 publication Critical patent/ES489521A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN PEPTIDO CON ACTIVIDAD SIMILAR A LA DE LA UBIQUITINA DE FORMULA A-B, DONDE A ES EL GRUPO FORMADO POR DESANIMO-GLN, GLN Y (SAR)N-GLN Y B ES UN MIEMBRO SELECCIONADO ENTRE EL GRUPO FORMADO POR LIS-OH, LIS NH2 DESCARBOXI-LIS, *FORMULA*. EL PROCEDIMIENTO CONSISTE EN UNIR UN AMINOACIDO B PROTEGIDO EN SU GRUPO ALFA-AMINO A UNA RESINA POLIMERICA MEDIANTE UN ENLACE COVALENTE. EL POLIMERO CONTIENE UN GRUPO FUNCIONAL AL QUE SER FIRMEMENTE LIGADO MEDIANTE EL ENLACE COVALENTE EL PRIMER AMINOACIDO PROTEGIDO Y SE PREPARAN SALES FARMACEUTICAS ACEPTABLES. A
ES489521A 1979-03-14 1980-03-13 Un procedimiento para la preparacion de un peptido Granted ES489521A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/020,157 US4215111A (en) 1979-03-14 1979-03-14 Peptides having ubiquitin-like activity

Publications (2)

Publication Number Publication Date
ES8103026A1 true ES8103026A1 (es) 1981-02-16
ES489521A0 ES489521A0 (es) 1981-02-16

Family

ID=21797065

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489521A Granted ES489521A0 (es) 1979-03-14 1980-03-13 Un procedimiento para la preparacion de un peptido

Country Status (18)

Country Link
US (1) US4215111A (es)
EP (1) EP0016612B1 (es)
JP (1) JPS55143946A (es)
AT (1) ATE1856T1 (es)
AU (1) AU544923B2 (es)
CA (1) CA1146166A (es)
DE (1) DE3061127D1 (es)
DK (1) DK149091C (es)
ES (1) ES489521A0 (es)
FI (1) FI67691C (es)
GR (1) GR68038B (es)
IE (1) IE49423B1 (es)
IL (1) IL59603A (es)
NO (1) NO149998C (es)
NZ (1) NZ193077A (es)
PT (1) PT70948B (es)
YU (1) YU41913B (es)
ZA (1) ZA801483B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4369137A (en) * 1980-06-17 1983-01-18 Ortho Pharmaceutical Corporation N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide
US4289759A (en) * 1980-06-23 1981-09-15 Ortho Pharmaceutical Corporation Immunoregulatory diketopiperazine compounds
US4481191A (en) * 1983-03-30 1984-11-06 The Regents Of The University Of California Method for controlling blood pressure
WO1986004334A1 (en) * 1985-01-18 1986-07-31 MERCK Patent Gesellschaft mit beschränkter Haftung Immunoregulatory peptides
JPH01104193A (ja) * 1986-06-10 1989-04-21 Kyowa Hakko Kogyo Co Ltd 新規ポリペプチド
CA2161108A1 (en) * 1993-04-23 1994-11-10 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US5770720A (en) * 1995-08-30 1998-06-23 Barnes-Jewish Hospital Ubiquitin conjugating enzymes having transcriptional repressor activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113858A (en) * 1975-01-20 1978-09-12 St. Luke's Hospital Novel compounds, compositions and methods of their use
FR2391994A1 (fr) * 1977-05-25 1978-12-22 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese
SE446867B (sv) * 1977-11-15 1986-10-13 Sloan Kettering Inst Cancer Sett att framstella en polypeptid med formaga att inducera differentiering av t-lymfocyter men inte av komplementreceptor (cr?72+) b-lymfocyter
SE446866B (sv) * 1977-11-15 1986-10-13 Sloan Kettering Inst Cancer Sett att framstella en aktiv polypeptid med formaga att inducera differentiering av bade t-lymfocyter och komplementreceptor (cr?72+) b-lymfocyter
NZ189101A (en) * 1977-12-08 1984-07-06 Ortho Pharma Corp Polypeptides having the ability to induce differentiation of both th-1+ t-lymphocytes and bu-1+ b-lymphocytes;pharmaceutical compositions

Also Published As

Publication number Publication date
PT70948A (en) 1980-04-01
IE800515L (en) 1980-09-14
US4215111A (en) 1980-07-29
EP0016612A2 (en) 1980-10-01
EP0016612A3 (en) 1981-01-07
ZA801483B (en) 1981-10-28
GR68038B (es) 1981-10-27
DK109180A (da) 1980-09-15
ES489521A0 (es) 1981-02-16
FI800779A (fi) 1980-09-15
JPH0153268B2 (es) 1989-11-13
FI67691C (fi) 1985-05-10
AU544923B2 (en) 1985-06-20
DE3061127D1 (en) 1982-12-30
YU65980A (en) 1984-02-29
ATE1856T1 (de) 1982-12-15
DK149091C (da) 1986-06-16
IL59603A (en) 1983-02-23
FI67691B (fi) 1985-01-31
YU41913B (en) 1988-02-29
DK149091B (da) 1986-01-20
IE49423B1 (en) 1985-10-02
NZ193077A (en) 1984-05-31
NO800724L (no) 1980-09-15
IL59603A0 (en) 1980-06-30
AU5631380A (en) 1980-09-18
NO149998B (no) 1984-04-24
CA1146166A (en) 1983-05-10
PT70948B (en) 1981-06-24
NO149998C (no) 1984-08-01
JPS55143946A (en) 1980-11-10
EP0016612B1 (en) 1982-11-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603