ES551963A0 - Un procedimiento para la preparacion de un derivado tetraciclico de espiro-hidantoina biologicamente activo - Google Patents
Un procedimiento para la preparacion de un derivado tetraciclico de espiro-hidantoina biologicamente activoInfo
- Publication number
- ES551963A0 ES551963A0 ES551963A ES551963A ES551963A0 ES 551963 A0 ES551963 A0 ES 551963A0 ES 551963 A ES551963 A ES 551963A ES 551963 A ES551963 A ES 551963A ES 551963 A0 ES551963 A0 ES 551963A0
- Authority
- ES
- Spain
- Prior art keywords
- conh
- chem
- disclosed
- tetraciclic
- hydantoine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002249 Diabetes Complications Diseases 0.000 abstract 2
- 206010012655 Diabetic complications Diseases 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 hydroxy, methyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- QAHZIGHCEBUNGT-QMGFNSACSA-N (5r,6s,7s,8r,9r)-6,7,8-trihydroxy-9-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)C[C@]11C(=O)NC(=O)N1 QAHZIGHCEBUNGT-QMGFNSACSA-N 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1984/001290 WO1986001107A1 (en) | 1984-08-14 | 1984-08-14 | Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801831A1 ES8801831A1 (es) | 1988-02-16 |
| ES551963A0 true ES551963A0 (es) | 1988-02-16 |
Family
ID=22182231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546093A Expired ES8704495A1 (es) | 1984-08-14 | 1985-08-12 | Un procedimiento para la preparacion de un derivado tetraci-clico de espirohidantoina biologicamente activo. |
| ES551963A Expired ES8801831A1 (es) | 1984-08-14 | 1986-02-13 | Un procedimiento para la preparacion de un derivado tetraciclico de espiro-hidantoina biologicamente activo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546093A Expired ES8704495A1 (es) | 1984-08-14 | 1985-08-12 | Un procedimiento para la preparacion de un derivado tetraci-clico de espirohidantoina biologicamente activo. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4656169A (es) |
| EP (1) | EP0173497B1 (es) |
| JP (1) | JPS6147486A (es) |
| KR (1) | KR870000624B1 (es) |
| AT (1) | ATE46162T1 (es) |
| AU (1) | AU553699B2 (es) |
| CA (1) | CA1255304A (es) |
| DD (1) | DD236529A5 (es) |
| DE (1) | DE3572818D1 (es) |
| DK (1) | DK366685A (es) |
| ES (2) | ES8704495A1 (es) |
| FI (1) | FI82695C (es) |
| GR (1) | GR851968B (es) |
| IE (1) | IE58123B1 (es) |
| IL (1) | IL76076A0 (es) |
| IN (2) | IN166581B (es) |
| NO (1) | NO164101C (es) |
| NZ (1) | NZ213085A (es) |
| PH (1) | PH22910A (es) |
| PL (2) | PL147875B1 (es) |
| PT (1) | PT80940B (es) |
| WO (1) | WO1986001107A1 (es) |
| YU (1) | YU44894B (es) |
| ZA (1) | ZA856102B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202339A (en) * | 1987-08-28 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
| US5004751A (en) * | 1987-08-28 | 1991-04-02 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
| WO1990002126A1 (en) * | 1988-08-24 | 1990-03-08 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
| TW202450B (es) * | 1991-06-26 | 1993-03-21 | Dainippon Pharmaceutical Co |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4193996A (en) * | 1979-04-04 | 1980-03-18 | Pfizer Inc. | Spiro-quinolone hydantoins |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1984
- 1984-08-14 WO PCT/US1984/001290 patent/WO1986001107A1/en not_active Ceased
- 1984-08-14 US US06/854,588 patent/US4656169A/en not_active Expired - Fee Related
-
1985
- 1985-07-15 IN IN552/DEL/85A patent/IN166581B/en unknown
- 1985-08-08 EP EP85305636A patent/EP0173497B1/en not_active Expired
- 1985-08-08 AT AT85305636T patent/ATE46162T1/de not_active IP Right Cessation
- 1985-08-08 DE DE8585305636T patent/DE3572818D1/de not_active Expired
- 1985-08-12 ES ES546093A patent/ES8704495A1/es not_active Expired
- 1985-08-12 GR GR851968A patent/GR851968B/el unknown
- 1985-08-12 IL IL76076A patent/IL76076A0/xx not_active IP Right Cessation
- 1985-08-12 DD DD85279599A patent/DD236529A5/de not_active IP Right Cessation
- 1985-08-12 JP JP60177463A patent/JPS6147486A/ja active Granted
- 1985-08-12 CA CA000488544A patent/CA1255304A/en not_active Expired
- 1985-08-12 PT PT80940A patent/PT80940B/pt not_active IP Right Cessation
- 1985-08-13 YU YU1290/85A patent/YU44894B/xx unknown
- 1985-08-13 IE IE199185A patent/IE58123B1/en not_active IP Right Cessation
- 1985-08-13 KR KR1019850005822A patent/KR870000624B1/ko not_active Expired
- 1985-08-13 AU AU46126/85A patent/AU553699B2/en not_active Ceased
- 1985-08-13 PL PL1985261413A patent/PL147875B1/pl unknown
- 1985-08-13 ZA ZA856102A patent/ZA856102B/xx unknown
- 1985-08-13 DK DK366685A patent/DK366685A/da not_active Application Discontinuation
- 1985-08-13 PL PL1985254960A patent/PL145221B1/pl unknown
- 1985-08-13 NZ NZ213085A patent/NZ213085A/en unknown
- 1985-08-14 PH PH32632A patent/PH22910A/en unknown
-
1986
- 1986-02-13 ES ES551963A patent/ES8801831A1/es not_active Expired
- 1986-04-11 NO NO86861425A patent/NO164101C/no unknown
- 1986-04-11 FI FI861544A patent/FI82695C/fi not_active IP Right Cessation
-
1987
- 1987-06-17 IN IN522/DEL/87A patent/IN166590B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |