ATE46162T1 - Tetracyclische spiro-hydantoin-aldose-reduktase- inhibitoren. - Google Patents

Tetracyclische spiro-hydantoin-aldose-reduktase- inhibitoren.

Info

Publication number
ATE46162T1
ATE46162T1 AT85305636T AT85305636T ATE46162T1 AT E46162 T1 ATE46162 T1 AT E46162T1 AT 85305636 T AT85305636 T AT 85305636T AT 85305636 T AT85305636 T AT 85305636T AT E46162 T1 ATE46162 T1 AT E46162T1
Authority
AT
Austria
Prior art keywords
conh
chem
disclosed
aldose reductase
conh2
Prior art date
Application number
AT85305636T
Other languages
English (en)
Inventor
Rodney Caughren Schnur
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE46162T1 publication Critical patent/ATE46162T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185Saturated compounds having only one carboxyl group and containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT85305636T 1984-08-14 1985-08-08 Tetracyclische spiro-hydantoin-aldose-reduktase- inhibitoren. ATE46162T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001290 WO1986001107A1 (en) 1984-08-14 1984-08-14 Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making

Publications (1)

Publication Number Publication Date
ATE46162T1 true ATE46162T1 (de) 1989-09-15

Family

ID=22182231

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85305636T ATE46162T1 (de) 1984-08-14 1985-08-08 Tetracyclische spiro-hydantoin-aldose-reduktase- inhibitoren.

Country Status (24)

Country Link
US (1) US4656169A (de)
EP (1) EP0173497B1 (de)
JP (1) JPS6147486A (de)
KR (1) KR870000624B1 (de)
AT (1) ATE46162T1 (de)
AU (1) AU553699B2 (de)
CA (1) CA1255304A (de)
DD (1) DD236529A5 (de)
DE (1) DE3572818D1 (de)
DK (1) DK366685A (de)
ES (2) ES8704495A1 (de)
FI (1) FI82695C (de)
GR (1) GR851968B (de)
IE (1) IE58123B1 (de)
IL (1) IL76076A0 (de)
IN (2) IN166581B (de)
NO (1) NO164101C (de)
NZ (1) NZ213085A (de)
PH (1) PH22910A (de)
PL (2) PL147875B1 (de)
PT (1) PT80940B (de)
WO (1) WO1986001107A1 (de)
YU (1) YU44894B (de)
ZA (1) ZA856102B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5202339A (en) * 1987-08-28 1993-04-13 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
AU623676B2 (en) * 1988-08-24 1992-05-21 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
TW202450B (de) * 1991-06-26 1993-03-21 Dainippon Pharmaceutical Co

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4193996A (en) * 1979-04-04 1980-03-18 Pfizer Inc. Spiro-quinolone hydantoins
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
IN166581B (de) 1990-06-09
FI82695B (fi) 1990-12-31
US4656169A (en) 1987-04-07
DK366685D0 (da) 1985-08-13
FI82695C (fi) 1991-04-10
NO861425L (no) 1986-04-11
ES8704495A1 (es) 1987-04-01
DK366685A (da) 1986-02-15
JPH0339512B2 (de) 1991-06-14
IE58123B1 (en) 1993-07-14
IE851991L (en) 1986-02-14
EP0173497B1 (de) 1989-09-06
FI861544A0 (fi) 1986-04-11
ES551963A0 (es) 1988-02-16
JPS6147486A (ja) 1986-03-07
PH22910A (en) 1989-01-24
ES8801831A1 (es) 1988-02-16
NO164101C (no) 1990-08-29
YU129085A (en) 1988-04-30
IL76076A0 (en) 1985-12-31
YU44894B (en) 1991-04-30
PL254960A1 (en) 1987-01-12
KR870000624B1 (ko) 1987-03-26
PL261413A1 (en) 1988-01-21
PT80940A (en) 1985-09-01
DE3572818D1 (en) 1989-10-12
NO164101B (no) 1990-05-21
EP0173497A1 (de) 1986-03-05
PL145221B1 (en) 1988-08-31
NZ213085A (en) 1988-03-30
DD236529A5 (de) 1986-06-11
WO1986001107A1 (en) 1986-02-27
FI861544A (fi) 1986-04-11
IN166590B (de) 1990-06-09
ZA856102B (en) 1987-03-25
AU553699B2 (en) 1986-07-24
ES546093A0 (es) 1987-04-01
PT80940B (pt) 1987-12-30
CA1255304A (en) 1989-06-06
AU4612685A (en) 1986-02-20
KR860001811A (ko) 1986-03-22
GR851968B (de) 1985-12-13
PL147875B1 (en) 1989-08-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee