ES536199A0 - Procedimiento para preparar derivados de -carbolina sustituidos - Google Patents
Procedimiento para preparar derivados de -carbolina sustituidosInfo
- Publication number
- ES536199A0 ES536199A0 ES536199A ES536199A ES536199A0 ES 536199 A0 ES536199 A0 ES 536199A0 ES 536199 A ES536199 A ES 536199A ES 536199 A ES536199 A ES 536199A ES 536199 A0 ES536199 A0 ES 536199A0
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- lower alkyl
- image
- procedure
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Treating Waste Gases (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3335323A DE3335323A1 (de) | 1983-09-27 | 1983-09-27 | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8505368A1 ES8505368A1 (es) | 1985-06-01 |
| ES536199A0 true ES536199A0 (es) | 1985-06-01 |
Family
ID=6210425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES536199A Granted ES536199A0 (es) | 1983-09-27 | 1984-09-25 | Procedimiento para preparar derivados de -carbolina sustituidos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4623649A (es) |
| EP (1) | EP0137390B1 (es) |
| JP (1) | JPS60100577A (es) |
| AT (1) | ATE55604T1 (es) |
| AU (1) | AU578043B2 (es) |
| CA (1) | CA1263394A (es) |
| DD (1) | DD223714A5 (es) |
| DE (2) | DE3335323A1 (es) |
| DK (1) | DK170256B1 (es) |
| ES (1) | ES536199A0 (es) |
| FI (1) | FI843777L (es) |
| GR (1) | GR80482B (es) |
| HU (1) | HU200457B (es) |
| IE (1) | IE57670B1 (es) |
| IL (1) | IL73071A (es) |
| NO (1) | NO160998C (es) |
| PT (1) | PT79264B (es) |
| ZA (1) | ZA847619B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK240184D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
| DK240084D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | New beta-carboline-3-oxadiazolyl derivatives |
| DE3535927A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE3540653A1 (de) * | 1985-11-13 | 1987-05-14 | Schering Ag | Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE3545776A1 (de) * | 1985-12-20 | 1987-06-25 | Schering Ag | 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4952584A (en) * | 1986-01-11 | 1990-08-28 | Beecham Group P.L.C. | 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity |
| DE3609699A1 (de) * | 1986-03-20 | 1987-09-24 | Schering Ag | 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester |
| DE3608089A1 (de) * | 1986-03-08 | 1987-09-10 | Schering Ag | Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| DE4130933A1 (de) * | 1991-09-13 | 1993-03-18 | Schering Ag | Neue (beta)-carbolinderivate, deren herstellung und verwendung in arzneimitteln |
| US5585490A (en) * | 1991-10-08 | 1996-12-17 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands |
| WO1994025463A1 (en) * | 1992-04-08 | 1994-11-10 | Neurogen Corporation | Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands |
| US5367077A (en) * | 1992-04-08 | 1994-11-22 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands |
| US5286860A (en) * | 1992-11-12 | 1994-02-15 | Neurogen Corporation | Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands |
| US5750702A (en) * | 1993-10-27 | 1998-05-12 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands |
| US5484944A (en) * | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| US6211365B1 (en) | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| WO1997034870A1 (en) | 1996-03-22 | 1997-09-25 | Neurogen Corporation | Certain fused pyrrolecarboxamides as gaba brain receptor ligands |
| US5723462A (en) * | 1996-04-26 | 1998-03-03 | Neurogen Corporation | Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands |
| MXPA02001709A (es) | 1999-08-31 | 2002-10-23 | Neurogen Corp | Pirrolocarboxamidas fusionadas: ligandos receptores de acido gaba-aminobutirico cerebral. |
| US20050014939A1 (en) * | 1999-08-31 | 2005-01-20 | Neurogen Corporation | Fused pyrrolecarboxamides: GABA brain receptor ligands |
| US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3058909A (en) | 1957-07-23 | 1962-10-16 | Atlantic Refining Co | Method and composition for formation fracturing |
| US3163219A (en) | 1961-06-22 | 1964-12-29 | Atlantic Refining Co | Borate-gum gel breakers |
| US3215634A (en) | 1962-10-16 | 1965-11-02 | Jersey Prod Res Co | Method for stabilizing viscous liquids |
| GB1084256A (es) * | 1963-11-06 | |||
| US3741894A (en) | 1967-06-15 | 1973-06-26 | Exxon Production Research Co | Chemically modified organic polymers |
| US3696035A (en) | 1970-11-04 | 1972-10-03 | Dow Chemical Co | Well treatments with thickened aqueous alcohol mixtures |
| US3727688A (en) | 1972-02-09 | 1973-04-17 | Phillips Petroleum Co | Hydraulic fracturing method |
| US3768566A (en) | 1972-04-18 | 1973-10-30 | Halliburton Co | Methods for fracturing high temperature well formations |
| US3848673A (en) | 1973-02-26 | 1974-11-19 | Phillips Petroleum Co | Recovery of hydrocarbons |
| US4033415A (en) | 1973-03-30 | 1977-07-05 | Halliburton Company | Methods for fracturing well formations |
| DE2415155C2 (de) | 1974-03-29 | 1985-05-23 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 2,3-Dihydroxypropylcellulose |
| DE2415154C2 (de) | 1974-03-29 | 1985-05-23 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von Cellulosemischethern, die neben Alkylgruppen, Hydroxyalkylgruppen oder Carboxyalkylgruppen noch 2,3-Dihydroxypropylgruppen enthalten |
| US3888312A (en) | 1974-04-29 | 1975-06-10 | Halliburton Co | Method and compositions for fracturing well formations |
| US3978928A (en) | 1975-04-14 | 1976-09-07 | Phillips Petroleum Company | Process for the production of fluids from subterranean formations |
| US4144179A (en) | 1975-07-21 | 1979-03-13 | Halliburton Company | Composition for treating low temperature subterranean well formations |
| US4096326A (en) | 1976-10-13 | 1978-06-20 | Hercules Incorporated | Dihydroxypropyl cellulose |
| US4323123A (en) | 1978-07-17 | 1982-04-06 | Phillips Petroleum Company | Gelled compositions and well treating |
| DE3023567A1 (de) * | 1980-06-20 | 1982-01-21 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Substituierte (beta) -carbolin-3-carbonsaeurederivate |
| NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
| JPS574987A (en) * | 1980-06-09 | 1982-01-11 | Sankyo Co Ltd | Pyridoindolecarboxylic acid derivative and its preparation |
| DE3048318A1 (de) * | 1980-12-17 | 1982-07-22 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 4-alkoxyalkyl substituierte (beta)-carbolin-3-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3136857A1 (de) * | 1981-09-14 | 1983-03-31 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Substituierte (beta)-carbolin-3-carbonsaeurealkylester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| GB2115408B (en) * | 1982-02-09 | 1985-10-16 | Ici Plc | Triazole and imidazole derivatives |
| DE3240513A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung |
| DE3240511A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinderivaten |
| DE3322894A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h) |
-
1983
- 1983-09-27 DE DE3335323A patent/DE3335323A1/de not_active Withdrawn
-
1984
- 1984-09-22 AT AT84111337T patent/ATE55604T1/de not_active IP Right Cessation
- 1984-09-22 DE DE8484111337T patent/DE3482984D1/de not_active Expired - Lifetime
- 1984-09-22 EP EP84111337A patent/EP0137390B1/de not_active Expired - Lifetime
- 1984-09-25 DK DK456484A patent/DK170256B1/da not_active IP Right Cessation
- 1984-09-25 PT PT79264A patent/PT79264B/pt not_active IP Right Cessation
- 1984-09-25 DD DD84267607A patent/DD223714A5/de not_active IP Right Cessation
- 1984-09-25 ES ES536199A patent/ES536199A0/es active Granted
- 1984-09-26 CA CA000464082A patent/CA1263394A/en not_active Expired
- 1984-09-26 IE IE2447/84A patent/IE57670B1/en not_active IP Right Cessation
- 1984-09-26 FI FI843777A patent/FI843777L/fi not_active Application Discontinuation
- 1984-09-26 US US06/654,594 patent/US4623649A/en not_active Expired - Fee Related
- 1984-09-26 HU HU843650A patent/HU200457B/hu not_active IP Right Cessation
- 1984-09-26 NO NO843861A patent/NO160998C/no unknown
- 1984-09-26 IL IL73071A patent/IL73071A/xx unknown
- 1984-09-26 AU AU33570/84A patent/AU578043B2/en not_active Ceased
- 1984-09-26 GR GR80482A patent/GR80482B/el unknown
- 1984-09-27 ZA ZA847619A patent/ZA847619B/xx unknown
- 1984-09-27 JP JP59200717A patent/JPS60100577A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NO843861L (no) | 1985-03-28 |
| DK456484D0 (da) | 1984-09-25 |
| IE57670B1 (en) | 1993-02-24 |
| CA1263394A (en) | 1989-11-28 |
| PT79264A (de) | 1984-10-01 |
| AU3357084A (en) | 1985-04-04 |
| IL73071A (en) | 1988-06-30 |
| ES8505368A1 (es) | 1985-06-01 |
| FI843777L (fi) | 1985-03-28 |
| FI843777A0 (fi) | 1984-09-26 |
| JPH0586390B2 (es) | 1993-12-10 |
| GR80482B (en) | 1985-01-28 |
| DE3335323A1 (de) | 1985-04-04 |
| HU200457B (en) | 1990-06-28 |
| DK456484A (da) | 1985-03-28 |
| EP0137390B1 (de) | 1990-08-16 |
| EP0137390A1 (de) | 1985-04-17 |
| US4623649A (en) | 1986-11-18 |
| PT79264B (de) | 1986-08-08 |
| IE842447L (en) | 1985-03-27 |
| ATE55604T1 (de) | 1990-09-15 |
| HUT35673A (en) | 1985-07-29 |
| IL73071A0 (en) | 1984-12-31 |
| ZA847619B (en) | 1985-05-29 |
| NO160998B (no) | 1989-03-13 |
| JPS60100577A (ja) | 1985-06-04 |
| DK170256B1 (da) | 1995-07-17 |
| NO160998C (no) | 1989-06-21 |
| DE3482984D1 (de) | 1990-09-20 |
| DD223714A5 (de) | 1985-06-19 |
| AU578043B2 (en) | 1988-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000601 |