ES532818A0 - Procedimiento de producir un preparado de farmaco de toxicidad reducida - Google Patents
Procedimiento de producir un preparado de farmaco de toxicidad reducidaInfo
- Publication number
- ES532818A0 ES532818A0 ES532818A ES532818A ES532818A0 ES 532818 A0 ES532818 A0 ES 532818A0 ES 532818 A ES532818 A ES 532818A ES 532818 A ES532818 A ES 532818A ES 532818 A0 ES532818 A0 ES 532818A0
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- producing
- reduced toxicity
- drug preparation
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49826883A | 1983-05-26 | 1983-05-26 | |
| US60450384A | 1984-05-02 | 1984-05-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532818A0 true ES532818A0 (es) | 1985-12-16 |
| ES8603272A1 ES8603272A1 (es) | 1985-12-16 |
Family
ID=27052776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532818A Expired ES8603272A1 (es) | 1983-05-26 | 1984-05-25 | Procedimiento de producir un preparado de farmaco de toxicidad reducida |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4897384A (es) |
| KR (1) | KR850002401A (es) |
| CA (1) | CA1237670A (es) |
| ES (1) | ES8603272A1 (es) |
| GR (1) | GR79953B (es) |
| IL (1) | IL71908A0 (es) |
| IT (1) | IT1178947B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US4871718A (en) * | 1987-12-29 | 1989-10-03 | Raymond A. Roncari | Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair |
| US20010051183A1 (en) * | 1989-10-20 | 2001-12-13 | Alza Corporation | Liposomes with enhanced circulation time and method of treatment |
| CA2120234A1 (en) * | 1991-10-21 | 1993-04-29 | Jack B. Jiang | 2-aminopropan-1,3-diol chemotherapeutic agents |
| US5958449A (en) | 1992-12-02 | 1999-09-28 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for bacterial infections |
| WO1994012155A1 (en) * | 1992-12-02 | 1994-06-09 | Vestar, Inc. | Antibiotic formulation and process |
| JPH09502700A (ja) * | 1993-04-02 | 1997-03-18 | ザ リポソーム カンパニー、インコーポレーテッド | リポソームの製造方法 |
| US5759571A (en) * | 1993-05-11 | 1998-06-02 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for drug resistant infections |
| DK0707472T3 (da) | 1993-07-08 | 2001-04-17 | Liposome Co Inc | Fremgangsmåde til regulering af størrelsen af liposomer |
| US5716526A (en) * | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| AU740918B2 (en) * | 1997-01-10 | 2001-11-15 | Plantibodies Corporation | Novel epithelial tissue targeting agent |
| US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| US6165997A (en) * | 1997-11-20 | 2000-12-26 | Statens Serum Institut | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
| US6258375B1 (en) * | 1998-03-05 | 2001-07-10 | Abbott Laboratories | Antibacterial phosphoinositides |
| US6194379B1 (en) | 1998-05-01 | 2001-02-27 | Abbott Laboratories | Elemental enteral formula |
| CA2345532A1 (en) * | 1998-09-30 | 2000-04-06 | Joseph Shope | Delivery of phosphoinositide polyphosphates into cells |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| JP2005530704A (ja) * | 2002-03-05 | 2005-10-13 | トランセイブ， インク． | 細胞内感染を予防及び治療するための吸入システム |
| SI2363114T1 (sl) * | 2002-10-29 | 2015-07-31 | Insmed Incorporated | Zadržano sproščanje antiinfektivov |
| US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| PL1962805T3 (pl) | 2005-12-08 | 2017-01-31 | Insmed Incorporated | Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US20090061009A1 (en) * | 2007-08-29 | 2009-03-05 | Joseph Schwarz | Composition and Method of Treatment of Bacterial Infections |
| CN108743537B (zh) | 2012-05-21 | 2021-06-11 | 英斯麦德公司 | 治疗肺部感染的系统 |
| RU2018135921A (ru) | 2012-11-29 | 2019-02-05 | Инсмед Инкорпорейтед | Стабилизированные составы ванкомицина |
| ES2755941T3 (es) | 2014-05-15 | 2020-04-24 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
| WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| EP4312536A1 (en) | 2021-04-01 | 2024-02-07 | Vestaron Corporation | Liposome formulations for pesticide delivery and methods for producing and using the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962429A (en) * | 1973-08-01 | 1976-06-08 | Chugai Seiyaku Kabushiki Kaisha | Method for reducing side effects of aminoglycoside antibiotics and composition therefor |
| US4119724A (en) * | 1973-11-26 | 1978-10-10 | Pepro | Fungicidal compositions containing phosphorous acid and derivatives thereof |
| TR19072A (tr) * | 1973-11-26 | 1978-05-01 | Pepro | Fosforlu tuerevler ihtiva eden fungisid terkipler |
| US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
| US4160827A (en) * | 1978-02-06 | 1979-07-10 | The Upjohn Company | Metronidazole phosphate and salts |
| US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IL55431A (en) * | 1978-08-24 | 1982-07-30 | Yeda Res & Dev | Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them |
| DE2856333C2 (de) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung |
| US4272525A (en) * | 1978-10-23 | 1981-06-09 | Schering Corporation | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| GR73668B (es) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche | |
| GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
| US4291027A (en) * | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes |
| US4291023A (en) * | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors using cis-diammineplatinum (II) organophosphate complexes |
| US4287187A (en) * | 1979-03-07 | 1981-09-01 | Engelhard Minerals & Chemicals Corporation | Method for treating tumors with cis-diammineplatinum(II) orthophosphate complexes |
| JPS55127162A (en) * | 1979-03-22 | 1980-10-01 | Fujio Kurata | System and apparatus for protecting insulator in electric dust collector |
| DE2914789A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Injizierbare arzneimittel mit entzuendungshemmender wirkung |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| DE2952115C2 (de) * | 1979-12-22 | 1982-05-06 | A. Nattermann & Cie GmbH, 5000 Köln | Rosmarinsäure-Phospholipid-Komplex |
| US4430330A (en) * | 1980-02-29 | 1984-02-07 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering a phenothiazine and choline |
| US4346084A (en) * | 1980-02-29 | 1982-08-24 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lithium and choline |
| US4419348A (en) * | 1981-04-27 | 1983-12-06 | Georgetown University | Anthracycline glycoside compositions, their use and preparation |
| US4397846A (en) * | 1981-05-15 | 1983-08-09 | Murray Weiner | Storage-stable lipid vesicles and method of preparation |
| DE3125422A1 (de) * | 1981-06-27 | 1983-01-27 | A. Nattermann & Cie GmbH, 5000 Köln | Neue fungizid-zusammensetzung, verfahren zur herstellung und deren verwendung |
| DE3125423A1 (de) * | 1981-06-27 | 1983-01-13 | A. Nattermann & Cie GmbH, 5000 Köln | Neue insektizid-zusammensetzung, verfahren zur herstellung und deren verwendung |
-
1984
- 1984-05-11 CA CA000454193A patent/CA1237670A/en not_active Expired
- 1984-05-16 GR GR74739A patent/GR79953B/el unknown
- 1984-05-23 IL IL71908A patent/IL71908A0/xx unknown
- 1984-05-25 ES ES532818A patent/ES8603272A1/es not_active Expired
- 1984-05-25 IT IT67535/84A patent/IT1178947B/it active
- 1984-05-26 KR KR1019840002901A patent/KR850002401A/ko not_active Application Discontinuation
-
1986
- 1986-03-24 US US06/844,248 patent/US4897384A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT8467535A1 (it) | 1985-11-25 |
| KR850002401A (ko) | 1985-05-13 |
| IT8467535A0 (it) | 1984-05-25 |
| CA1237670A (en) | 1988-06-07 |
| US4897384A (en) | 1990-01-30 |
| ES8603272A1 (es) | 1985-12-16 |
| GR79953B (es) | 1984-10-31 |
| IL71908A0 (en) | 1984-09-30 |
| IT1178947B (it) | 1987-09-16 |
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