ES504693A0 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents

Un procedimiento para la preparacion de un derivado del indol.

Info

Publication number
ES504693A0
ES504693A0 ES504693A ES504693A ES504693A0 ES 504693 A0 ES504693 A0 ES 504693A0 ES 504693 A ES504693 A ES 504693A ES 504693 A ES504693 A ES 504693A ES 504693 A0 ES504693 A0 ES 504693A0
Authority
ES
Spain
Prior art keywords
indol
derivative
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES504693A
Other languages
English (en)
Spanish (es)
Other versions
ES8301210A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8301210A1 publication Critical patent/ES8301210A1/es
Publication of ES504693A0 publication Critical patent/ES504693A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES504693A 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol. Granted ES504693A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
ES8301210A1 ES8301210A1 (es) 1982-12-01
ES504693A0 true ES504693A0 (es) 1982-12-01

Family

ID=10515410

Family Applications (5)

Application Number Title Priority Date Filing Date
ES504693A Granted ES504693A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513933A Granted ES513933A0 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Expired ES8500903A1 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES513933A Granted ES513933A0 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Expired ES8500903A1 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Country Status (16)

Country Link
US (1) US4650810A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5764669A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU548467B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE889929A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1169428A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH651551A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3131728A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK157920C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (5) ES504693A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2488607A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE51491B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1171449B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8103769A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ197996A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE454880B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA815540B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
DE3678805D1 (de) * 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
ES2104708T3 (es) * 1990-06-07 1997-10-16 Zeneca Ltd Compuestos heterociclicos terapeuticos.
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
WO2002079153A1 (en) * 2001-03-28 2002-10-10 Biocatalytics, Inc. Method for producing tryptamine derivatives
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US7645886B2 (en) * 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
ES2691033T3 (es) * 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
CL2008000838A1 (es) 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios
MX2009010302A (es) 2007-03-29 2009-10-16 Asubio Pharma Co Ltd Derivados de indol que tienen actividad inhibidora de cpla2 y aplicaciones y metodos de produccion.
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP2734634B1 (en) 2011-07-22 2019-08-21 The University of Chicago Igf-1 for use in the treatment of migraine
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
ES8504706A1 (es) 1985-05-01
FR2488607B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-11-16
DE3131728C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-04-30
SE8104781L (sv) 1982-02-13
DK157920C (da) 1990-08-06
DK157920B (da) 1990-03-05
SE454880B (sv) 1988-06-06
JPH0247462B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-10-19
JPS5764669A (en) 1982-04-19
ES8500902A1 (es) 1984-11-01
AU548467B2 (en) 1985-12-12
BE889929A (fr) 1982-02-11
IE51491B1 (en) 1987-01-07
CH651551A5 (fr) 1985-09-30
ES8301210A1 (es) 1982-12-01
ES8402268A1 (es) 1984-01-16
DE3131728A1 (de) 1982-03-11
NL8103769A (nl) 1982-03-01
US4650810A (en) 1987-03-17
ES520784A0 (es) 1984-11-01
IT1171449B (it) 1987-06-10
ES513933A0 (es) 1984-01-16
DK357081A (da) 1982-02-13
IT8149084A0 (it) 1981-08-11
ES520785A0 (es) 1984-11-01
ES520783A0 (es) 1985-05-01
AU7399481A (en) 1982-02-18
CA1169428A (en) 1984-06-19
IE811830L (en) 1982-02-12
FR2488607A1 (fr) 1982-02-19
ZA815540B (en) 1983-03-30
ES8500903A1 (es) 1984-11-01
NZ197996A (en) 1985-08-16

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