ES484112A1 - Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina - Google Patents

Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina

Info

Publication number
ES484112A1
ES484112A1 ES484112A ES484112A ES484112A1 ES 484112 A1 ES484112 A1 ES 484112A1 ES 484112 A ES484112 A ES 484112A ES 484112 A ES484112 A ES 484112A ES 484112 A1 ES484112 A1 ES 484112A1
Authority
ES
Spain
Prior art keywords
alkoxy
hydroxy
manufacture
pharmaceutical compositions
platelet aggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484112A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES484112A1 publication Critical patent/ES484112A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Derivado de 1-bencil-1,2,3,6-tetrahidropiridina. Las sales de adición de ácido de los compuestos de la fórmula I que son especialmente aceptables desde el punto de vista farmacéutico son, por ejemplo, sales con ácidos inorgánicos tales como sales de clorhidratos, bromhidratos, sulfatos o fosfatos, o sales con ácidos orgánicos que ofrezcan un anión farmacéuticamente aceptable, tales como sales de tartratos, citratos, lactatos, fumaratos, tolueno-p-sultonatos u oxalatos. El proceso se efectúa convenientemente en un diluyente o disolvente inerte, tal como tetrahidrofurano cuando se emplea un hidruro de aluminio como agente reductor, o por ejemplo, un alcanol C1-4, tal como etanol, cuando su emplea un borohidruro o cianoborohidruro como agente reductor. De preferencia, el proceso se efectúa a la temperatura ambiente, aproximadamente, por ejemplo, entre los 15º y 35ºC.
ES484112A 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina Expired ES484112A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1432378 1978-04-12
GB7840272 1978-10-12

Publications (1)

Publication Number Publication Date
ES484112A1 true ES484112A1 (es) 1980-04-16

Family

ID=26250483

Family Applications (3)

Application Number Title Priority Date Filing Date
ES479561A Expired ES479561A1 (es) 1978-04-12 1979-04-11 Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.
ES484111A Expired ES484111A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina
ES484112A Expired ES484112A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES479561A Expired ES479561A1 (es) 1978-04-12 1979-04-11 Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.
ES484111A Expired ES484111A1 (es) 1978-04-12 1979-09-12 Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina

Country Status (17)

Country Link
US (1) US4645771A (es)
EP (1) EP0004727B1 (es)
AT (1) AT371443B (es)
AU (1) AU528873B2 (es)
CA (1) CA1118778A (es)
DE (1) DE2960612D1 (es)
DK (1) DK152979A (es)
ES (3) ES479561A1 (es)
FI (1) FI791189A (es)
GR (1) GR68387B (es)
HU (1) HU178589B (es)
IL (1) IL57249A (es)
NO (1) NO152558C (es)
NZ (1) NZ190092A (es)
PH (1) PH14565A (es)
PT (1) PT69489A (es)
ZW (1) ZW7179A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229385A (en) * 1986-01-30 1993-07-20 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
HU209573B (en) * 1990-12-13 1994-08-29 Richter Gedeon Vegyeszet Process for producing of 1,2,3,6-tetrahydropyridine derivatives and pharmaceutical compositions comprising these substances
US5136040A (en) * 1991-02-26 1992-08-04 Eli Lilly And Company Preparation of substituted tetrahydropyridines
EP1151993A4 (en) * 1999-02-08 2002-04-10 Shionogi & Co CYCLIC AMINE DERIVATIVES AND THEIR APPLICATIONS
US6949656B2 (en) 2000-08-08 2005-09-27 Shionogi & Co., Ltd. Cyclic amine derivatives and use thereof
CN1487815A (zh) * 2001-01-23 2004-04-07 P&G克莱罗尔公司 用于氧化性染发的新的偶合剂
CN101376627B (zh) * 2008-09-26 2012-05-09 上海应用技术学院 4-羟基苯甲酰氯的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA778383A (en) * 1968-02-13 Marxer Adrian N-phenyl-lower alkyl-pyridinium compounds and process for preparing same
US3125488A (en) * 1964-03-17 Method of inducing analgesia by
US2609270A (en) * 1949-11-15 1952-09-02 Inst Textile Tech Mildewproof cellulose produced by reaction with chlord-benzyl quaternary ammonium salts
GB754372A (en) * 1953-05-11 1956-08-08 Schering Corp Pyridine and piperidine derivatives
US2967182A (en) * 1957-08-16 1961-01-03 Lilly Co Eli Novel substituted tetrahydropyridines
DE1445560C3 (de) * 1961-02-27 1974-05-16 Ciba-Geigy Ag, Basel (Schweiz) N-Dichlorbenzyl-4-alkyl-pyridiniumsalze und Verfahren zu ihrer Herstellung.
US3284457A (en) * 1964-01-17 1966-11-08 Degussa 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts
US3632767A (en) * 1968-02-12 1972-01-04 Mallinckrodt Chemical Works Treatment of depression with 4-substituted piperidines
DE2101998A1 (en) * 1971-01-16 1972-08-03 Bayer Ag Tetrahydropyridines prepn - from 1-benzyl-tetrahydropyridines
DE2101997A1 (en) * 1971-01-16 1972-08-03 Farbenfabriken Bayer AG, 509öfLeverkusen 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals
US3758483A (en) * 1971-05-28 1973-09-11 Hoffmann La Roche Tetrahydropyridine derivatives
US4028371A (en) * 1974-05-04 1977-06-07 Laboratorios Made, S.A. The compound 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride
ES425971A1 (es) * 1974-05-04 1976-09-16 Made Labor Sa Procedimiento para la preparacion de 1,3,4 - trimetil - 2- (3,4,5-trimetoxibencil)- 1,2,5,6-tetrahidropiridina.
DE2960095D1 (en) * 1978-04-12 1981-03-19 Ici Plc Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture

Also Published As

Publication number Publication date
GR68387B (es) 1981-12-28
US4645771A (en) 1987-02-24
ES479561A1 (es) 1979-12-01
DK152979A (da) 1979-10-13
AU528873B2 (en) 1983-05-19
CA1118778A (en) 1982-02-23
EP0004727A2 (en) 1979-10-17
NO152558C (no) 1985-10-16
IL57249A0 (en) 1979-09-30
PT69489A (en) 1979-05-01
NZ190092A (en) 1981-05-15
EP0004727A3 (en) 1979-10-31
FI791189A (fi) 1979-10-13
NO791237L (no) 1979-10-15
ZW7179A1 (en) 1980-11-26
ES484111A1 (es) 1980-04-16
HU178589B (en) 1982-05-28
NO152558B (no) 1985-07-08
DE2960612D1 (en) 1981-11-12
PH14565A (en) 1981-09-24
AU4581779A (en) 1979-10-18
ATA275379A (de) 1982-11-15
EP0004727B1 (en) 1981-08-12
IL57249A (en) 1982-12-31
AT371443B (de) 1983-06-27

Similar Documents

Publication Publication Date Title
AU2458392A (en) Novel medical use for tachykinin antagonists
MY121967A (en) New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
YU20999A (sh) Heterociklični derivati koji inhibiraju faktor xa
NO981911L (no) Anvendelse av rhodaninderivater for fremstilling av et medikament for behandling av Alzheimer's sykdom
NO160204C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alkalisalter av 5-metoksy-2(((4-metoksy-3,5-dimetyl-2-pyridinyl)-metyl)-sulfinyl)-1h-benzimidazol.
IE940525L (en) Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
HUP0401053A2 (hu) Oxibenzamid-származékok mint Xa faktor inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HU9303145D0 (en) Process for producing of fibrinogen receptor antagonist compounds and pharmaceutical compositions containing them as medical agent
CA2260016A1 (en) Substituted pyridines as selective cyclooxygenase-2 inhibitors
AU4437896A (en) Piperidine derivatives having tachykinin antagonist activity
HUT51637A (en) Process for producing heterocyclic derivatives of biphosphonic acid
EP0795548A4 (en) CHINAZOZINE DERIVATIVES AND THEIR USE
TR200101884T2 (tr) Farnesil transferaz inhibitörleri olarak 4-merkaptopirolidin türevleri.
AU2915892A (en) Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
IE830479L (en) Carboxyalkyl dipeptides
AU5514296A (en) Piperazinones useful as inhibitors of platelet aggregation
HUP9802762A2 (hu) Difenil-metilén-piperidin-származékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
ATE60579T1 (de) Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.
ES484112A1 (es) Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina
BG94282A (bg) 2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
CA2157792A1 (en) N-(3-piperidinyl-carbonyl)-beta-alanine derivatives as paf antagonists
AU2689292A (en) Cyclohexaneacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
CA2049368A1 (en) Treatment of cerebro-vascular disorders
CA2506464A1 (en) Therapeutic agent for glaucoma comprising rho kinase inhibitor and .beta.-blocker
NO930499D0 (no) Fremgangsmaate for fremstilling av benzimidazolderivater