ES479561A1 - Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. - Google Patents
Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina.Info
- Publication number
- ES479561A1 ES479561A1 ES479561A ES479561A ES479561A1 ES 479561 A1 ES479561 A1 ES 479561A1 ES 479561 A ES479561 A ES 479561A ES 479561 A ES479561 A ES 479561A ES 479561 A1 ES479561 A1 ES 479561A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- hydroxy
- manufacture
- pharmaceutical compositions
- platelet aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedimiento para la obtención de derivados de l- bencil-1,2,3,6-tetrahidropiridina, de fórmula: **(Fórmula-01)** en donde R1 es hidrógeno o un radial alquilo C1-4; uno de R2, R3, R4, R5 y R6 es halógeno, alquilo C1-4, alcoxi C1-4, hidroxi, nitro, ciano, carbonilo (alcoxi C-1-4), alcanoilamino C1-4 o alquilsulfonamido C1-4; otro de R2, R3, R4, R5 y R6 es hidrógeno o un halógeno, hidroxi, nitro un radical alquilo c1-4 ó un radical alcoxi C1-4, y el resto de R2. R3, R4, R5 y R6 es hidrógeno; pero el anillo bencénico A es distinto a un radical 2- clorofenilo, 3,4-diclorofenilo, 3,5-diclorofenilo, 4-cloro-3-hidroxifenilo, 3,4-dihidrocxifenilo o 4- hidroxifenil, cuando R1 es hidrógeno; o una sal de adición de ácido farmaceúticamente aceptable de los mismos, caracterizado porque comprende reaccionar una 1,2,3,6-tetrahidropiridina de fórmula: **(Fórmula-02)** en la que R1 se define como anteriormente, con un haluro de bencilo de fórmula: **(Fórmula-03)** donde Hal es un átomo de cloro, bromo o yodo, y R2, R3, R4, R5 y R6 en el anillo B tienen los valores dados anteriormente para los del anillo A, excepto que cuando el anillo A lleva una radical hidroxi, el anillo B lleva un radical alcanoiloxi (1-4C) en la misma posición; tras lo cual cuando se desea una sal de adición de ácido farmaceúticamente aceptable, se hace reaccionar un compuesto de fórmula I con un ácido apropiado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1432378 | 1978-04-12 | ||
GB7840272 | 1978-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479561A1 true ES479561A1 (es) | 1979-12-01 |
Family
ID=26250483
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479561A Expired ES479561A1 (es) | 1978-04-12 | 1979-04-11 | Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. |
ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
ES484112A Expired ES484112A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
ES484112A Expired ES484112A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4645771A (es) |
EP (1) | EP0004727B1 (es) |
AT (1) | AT371443B (es) |
AU (1) | AU528873B2 (es) |
CA (1) | CA1118778A (es) |
DE (1) | DE2960612D1 (es) |
DK (1) | DK152979A (es) |
ES (3) | ES479561A1 (es) |
FI (1) | FI791189A (es) |
GR (1) | GR68387B (es) |
HU (1) | HU178589B (es) |
IL (1) | IL57249A (es) |
NO (1) | NO152558C (es) |
NZ (1) | NZ190092A (es) |
PH (1) | PH14565A (es) |
PT (1) | PT69489A (es) |
ZW (1) | ZW7179A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
IL81264A (en) * | 1986-01-30 | 1990-11-05 | Takeda Chemical Industries Ltd | Quinone derivatives,their production and pharmaceutical compositions containing them |
HU209573B (en) * | 1990-12-13 | 1994-08-29 | Richter Gedeon Vegyeszet | Process for producing of 1,2,3,6-tetrahydropyridine derivatives and pharmaceutical compositions comprising these substances |
US5136040A (en) * | 1991-02-26 | 1992-08-04 | Eli Lilly And Company | Preparation of substituted tetrahydropyridines |
WO2000046194A1 (fr) * | 1999-02-08 | 2000-08-10 | Shionogi & Co., Ltd. | Derives d'amine cyclique et leurs utilisations |
WO2002012191A1 (fr) | 2000-08-08 | 2002-02-14 | Shionogi & Co., Ltd. | Derives d'amines cycliques et utilisation |
CN1487815A (zh) * | 2001-01-23 | 2004-04-07 | P&G克莱罗尔公司 | 用于氧化性染发的新的偶合剂 |
CN101376627B (zh) * | 2008-09-26 | 2012-05-09 | 上海应用技术学院 | 4-羟基苯甲酰氯的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3125488A (en) * | 1964-03-17 | Method of inducing analgesia by | ||
CA778383A (en) * | 1968-02-13 | Marxer Adrian | N-phenyl-lower alkyl-pyridinium compounds and process for preparing same | |
US2609270A (en) * | 1949-11-15 | 1952-09-02 | Inst Textile Tech | Mildewproof cellulose produced by reaction with chlord-benzyl quaternary ammonium salts |
GB754372A (en) * | 1953-05-11 | 1956-08-08 | Schering Corp | Pyridine and piperidine derivatives |
US2967182A (en) * | 1957-08-16 | 1961-01-03 | Lilly Co Eli | Novel substituted tetrahydropyridines |
DE1445560C3 (de) * | 1961-02-27 | 1974-05-16 | Ciba-Geigy Ag, Basel (Schweiz) | N-Dichlorbenzyl-4-alkyl-pyridiniumsalze und Verfahren zu ihrer Herstellung. |
US3284457A (en) * | 1964-01-17 | 1966-11-08 | Degussa | 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts |
US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
DE2101997A1 (en) * | 1971-01-16 | 1972-08-03 | Farbenfabriken Bayer AG, 509öfLeverkusen | 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals |
DE2101998A1 (en) * | 1971-01-16 | 1972-08-03 | Bayer Ag | Tetrahydropyridines prepn - from 1-benzyl-tetrahydropyridines |
US3758483A (en) * | 1971-05-28 | 1973-09-11 | Hoffmann La Roche | Tetrahydropyridine derivatives |
US4028371A (en) * | 1974-05-04 | 1977-06-07 | Laboratorios Made, S.A. | The compound 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride |
ES425971A1 (es) * | 1974-05-04 | 1976-09-16 | Made Labor Sa | Procedimiento para la preparacion de 1,3,4 - trimetil - 2- (3,4,5-trimetoxibencil)- 1,2,5,6-tetrahidropiridina. |
DE2960095D1 (en) * | 1978-04-12 | 1981-03-19 | Ici Plc | Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture |
-
1979
- 1979-03-21 EP EP79300447A patent/EP0004727B1/en not_active Expired
- 1979-03-21 DE DE7979300447T patent/DE2960612D1/de not_active Expired
- 1979-03-31 GR GR58753A patent/GR68387B/el unknown
- 1979-04-02 NZ NZ190092A patent/NZ190092A/xx unknown
- 1979-04-03 CA CA000324750A patent/CA1118778A/en not_active Expired
- 1979-04-04 AU AU45817/79A patent/AU528873B2/en not_active Ceased
- 1979-04-10 ZW ZW71/79A patent/ZW7179A1/xx unknown
- 1979-04-10 PH PH22373A patent/PH14565A/en unknown
- 1979-04-11 HU HU79IE872A patent/HU178589B/hu unknown
- 1979-04-11 DK DK152979A patent/DK152979A/da not_active IP Right Cessation
- 1979-04-11 FI FI791189A patent/FI791189A/fi not_active Application Discontinuation
- 1979-04-11 ES ES479561A patent/ES479561A1/es not_active Expired
- 1979-04-11 NO NO791237A patent/NO152558C/no unknown
- 1979-04-12 PT PT69489A patent/PT69489A/pt unknown
- 1979-04-12 AT AT0275379A patent/AT371443B/de not_active IP Right Cessation
- 1979-05-10 IL IL57249A patent/IL57249A/xx unknown
- 1979-09-12 ES ES484111A patent/ES484111A1/es not_active Expired
- 1979-09-12 ES ES484112A patent/ES484112A1/es not_active Expired
-
1982
- 1982-09-30 US US06/428,822 patent/US4645771A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4581779A (en) | 1979-10-18 |
AU528873B2 (en) | 1983-05-19 |
PH14565A (en) | 1981-09-24 |
ES484111A1 (es) | 1980-04-16 |
IL57249A0 (en) | 1979-09-30 |
ES484112A1 (es) | 1980-04-16 |
ZW7179A1 (en) | 1980-11-26 |
HU178589B (en) | 1982-05-28 |
FI791189A (fi) | 1979-10-13 |
EP0004727A3 (en) | 1979-10-31 |
EP0004727B1 (en) | 1981-08-12 |
NO791237L (no) | 1979-10-15 |
PT69489A (en) | 1979-05-01 |
ATA275379A (de) | 1982-11-15 |
US4645771A (en) | 1987-02-24 |
EP0004727A2 (en) | 1979-10-17 |
AT371443B (de) | 1983-06-27 |
CA1118778A (en) | 1982-02-23 |
DK152979A (da) | 1979-10-13 |
IL57249A (en) | 1982-12-31 |
NO152558C (no) | 1985-10-16 |
DE2960612D1 (en) | 1981-11-12 |
GR68387B (es) | 1981-12-28 |
NO152558B (no) | 1985-07-08 |
NZ190092A (en) | 1981-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2458392A (en) | Novel medical use for tachykinin antagonists | |
MY121967A (en) | New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency | |
YU20999A (sh) | Heterociklični derivati koji inhibiraju faktor xa | |
NO981911L (no) | Anvendelse av rhodaninderivater for fremstilling av et medikament for behandling av Alzheimer's sykdom | |
NO160204C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive alkalisalter av 5-metoksy-2(((4-metoksy-3,5-dimetyl-2-pyridinyl)-metyl)-sulfinyl)-1h-benzimidazol. | |
HUP0401053A2 (hu) | Oxibenzamid-származékok mint Xa faktor inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HU9303145D0 (en) | Process for producing of fibrinogen receptor antagonist compounds and pharmaceutical compositions containing them as medical agent | |
CA2260016A1 (en) | Substituted pyridines as selective cyclooxygenase-2 inhibitors | |
EP0795548A4 (en) | CHINAZOZINE DERIVATIVES AND THEIR USE | |
MY106280A (en) | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use. | |
AU2915892A (en) | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation | |
IE830479L (en) | Carboxyalkyl dipeptides | |
AU3941989A (en) | Heterocyclic bisphosphonic acid derivatives | |
AU5514296A (en) | Piperazinones useful as inhibitors of platelet aggregation | |
HUP9802762A2 (hu) | Difenil-metilén-piperidin-származékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk | |
ES479561A1 (es) | Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. | |
HUT51601A (en) | Process for production of new derivatives of imidasoline and medical compositions containing them as active substance | |
CA2049368A1 (en) | Treatment of cerebro-vascular disorders | |
CA2506464A1 (en) | Therapeutic agent for glaucoma comprising rho kinase inhibitor and .beta.-blocker | |
NO930499D0 (no) | Fremgangsmaate for fremstilling av benzimidazolderivater | |
IE883360L (en) | Indan derivatives and process for preparation thereof | |
ES8100263A1 (es) | Procedimiento para preparar un derivado de acido 1-bencil-1,2,5,6-tetrahidropiridina-3-carboxilico | |
HK1018783A1 (en) | BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5 α-REDUCTASES INHIBITORS | |
ES8705382A1 (es) | Un procedimiento para la preparacion de nuevos derivados de carbaciclina. | |
NO922531L (no) | Middel for forhindring av og behandling av fiskesykdommer |