ES481873A1 - Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos. - Google Patents
Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos.Info
- Publication number
- ES481873A1 ES481873A1 ES481873A ES481873A ES481873A1 ES 481873 A1 ES481873 A1 ES 481873A1 ES 481873 A ES481873 A ES 481873A ES 481873 A ES481873 A ES 481873A ES 481873 A1 ES481873 A1 ES 481873A1
- Authority
- ES
- Spain
- Prior art keywords
- acid addition
- addition salts
- alkoxyethyl
- hydroxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782828039 DE2828039A1 (de) | 1978-06-26 | 1978-06-26 | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES481873A1 true ES481873A1 (es) | 1980-02-16 |
Family
ID=6042819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481873A Expired ES481873A1 (es) | 1978-06-26 | 1979-06-25 | Procedimiento para la preparacion de 2-(2-alcoxietil)-2'- hidroxi-6,7-benzomorfanos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4293556A (enEXAMPLES) |
| EP (1) | EP0006449B1 (enEXAMPLES) |
| JP (1) | JPS5513278A (enEXAMPLES) |
| AT (1) | ATE1947T1 (enEXAMPLES) |
| AU (1) | AU518470B2 (enEXAMPLES) |
| CA (1) | CA1107280A (enEXAMPLES) |
| DE (2) | DE2828039A1 (enEXAMPLES) |
| DK (1) | DK156719C (enEXAMPLES) |
| ES (1) | ES481873A1 (enEXAMPLES) |
| FI (1) | FI65064C (enEXAMPLES) |
| GR (1) | GR69233B (enEXAMPLES) |
| IE (1) | IE48430B1 (enEXAMPLES) |
| IL (1) | IL57648A (enEXAMPLES) |
| MX (1) | MX5680E (enEXAMPLES) |
| NO (1) | NO149888C (enEXAMPLES) |
| NZ (1) | NZ190816A (enEXAMPLES) |
| PH (1) | PH15864A (enEXAMPLES) |
| PT (1) | PT69823A (enEXAMPLES) |
| ZA (1) | ZA793150B (enEXAMPLES) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
| GB2144639B (en) * | 1983-08-11 | 1986-10-15 | Edward Carden | Jetting tube for use in micro-laryngeal surgery |
| JPS61294094A (ja) * | 1985-06-24 | 1986-12-24 | 東洋ベントナイト株式会社 | シ−ルド堀進に於ける裏込補助工法 |
| US5607941A (en) * | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| DE4121821A1 (de) * | 1991-07-02 | 1993-01-14 | Boehringer Ingelheim Kg | Neue benzomorphane und ihre verwendung als arzneimittel |
| JPH05312414A (ja) * | 1992-05-12 | 1993-11-22 | Yukimatsu Fujimoto | 集熱器二段の太陽熱温水器 |
| DE19528472A1 (de) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
| DE19740110A1 (de) | 1997-09-12 | 1999-03-18 | Boehringer Ingelheim Pharma | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6136980A (en) * | 1998-05-01 | 2000-10-24 | Boehringer Ingelheim Kg | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| US8859580B2 (en) | 2007-11-16 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5730021B2 (ja) | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| EP2300461B1 (en) | 2008-05-01 | 2013-04-17 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TW200950780A (en) | 2008-05-13 | 2009-12-16 | Boehringer Ingelheim Int | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| KR20110050459A (ko) | 2008-07-25 | 2011-05-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3417094A (en) * | 1965-05-05 | 1968-12-17 | Geigy Chem Corp | Optically active 1,2,3,4,5,6-hexahydro-6-phenyl - 2,6 - methano - 3 - benzazocines an |
| NL132138C (enEXAMPLES) * | 1966-05-20 | |||
| US3499906A (en) * | 1966-05-20 | 1970-03-10 | Merck & Co Inc | 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans |
| BR6914879D0 (pt) * | 1969-01-23 | 1973-02-08 | Merck & Co Inc | Processos quimicos |
| JPS55383B2 (enEXAMPLES) * | 1971-09-13 | 1980-01-08 | ||
| DE2233088A1 (de) * | 1972-06-30 | 1974-01-17 | Schering Ag | Benzomorphanderivate |
| US4020164A (en) * | 1972-06-30 | 1977-04-26 | Schering Aktiengesellschaft | Benzomorphan derivatives |
| DE2411382C3 (de) * | 1974-03-09 | 1979-09-06 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung |
| DE2437610A1 (de) * | 1974-08-05 | 1976-02-26 | Boehringer Sohn Ingelheim | Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung |
| GB1513961A (en) * | 1975-02-25 | 1978-06-14 | Acf Chemiefarma Nv | 6,7-benzomorphans method for their preparation and intermediates |
-
1978
- 1978-06-26 DE DE19782828039 patent/DE2828039A1/de not_active Withdrawn
-
1979
- 1979-05-23 AT AT79101583T patent/ATE1947T1/de not_active IP Right Cessation
- 1979-05-23 EP EP79101583A patent/EP0006449B1/de not_active Expired
- 1979-05-23 DE DE7979101583T patent/DE2964196D1/de not_active Expired
- 1979-06-18 GR GR59372A patent/GR69233B/el unknown
- 1979-06-22 AU AU48327/79A patent/AU518470B2/en not_active Ceased
- 1979-06-25 NO NO792119A patent/NO149888C/no unknown
- 1979-06-25 FI FI792005A patent/FI65064C/fi not_active IP Right Cessation
- 1979-06-25 ES ES481873A patent/ES481873A1/es not_active Expired
- 1979-06-25 JP JP8006479A patent/JPS5513278A/ja active Granted
- 1979-06-25 IL IL57648A patent/IL57648A/xx unknown
- 1979-06-25 DK DK266179A patent/DK156719C/da not_active IP Right Cessation
- 1979-06-25 ZA ZA793150A patent/ZA793150B/xx unknown
- 1979-06-25 NZ NZ190816A patent/NZ190816A/xx unknown
- 1979-06-26 PT PT69823A patent/PT69823A/pt unknown
- 1979-06-26 CA CA330,576A patent/CA1107280A/en not_active Expired
- 1979-06-26 MX MX798111U patent/MX5680E/es unknown
- 1979-08-08 IE IE1189/79A patent/IE48430B1/en not_active IP Right Cessation
-
1980
- 1980-05-28 US US06/154,067 patent/US4293556A/en not_active Expired - Lifetime
- 1980-10-15 PH PH24730A patent/PH15864A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0006449A1 (de) | 1980-01-09 |
| CA1107280A (en) | 1981-08-18 |
| JPS5513278A (en) | 1980-01-30 |
| FI65064C (fi) | 1984-03-12 |
| PH15864A (en) | 1983-04-13 |
| DE2828039A1 (de) | 1980-01-10 |
| EP0006449B1 (de) | 1982-12-08 |
| DK156719C (da) | 1990-02-19 |
| IE791189L (en) | 1979-12-26 |
| FI65064B (fi) | 1983-11-30 |
| DK156719B (da) | 1989-09-25 |
| NO149888B (no) | 1984-04-02 |
| DK266179A (da) | 1979-12-27 |
| MX5680E (es) | 1983-12-08 |
| NZ190816A (en) | 1980-11-28 |
| AU4832779A (en) | 1980-01-03 |
| IE48430B1 (en) | 1985-01-23 |
| PT69823A (de) | 1979-07-01 |
| GR69233B (enEXAMPLES) | 1982-05-10 |
| IL57648A (en) | 1984-01-31 |
| DE2964196D1 (en) | 1983-01-13 |
| IL57648A0 (en) | 1979-10-31 |
| JPH0159271B2 (enEXAMPLES) | 1989-12-15 |
| NO149888C (no) | 1984-07-11 |
| ATE1947T1 (de) | 1982-12-15 |
| ZA793150B (en) | 1981-03-25 |
| FI792005A7 (fi) | 1979-12-27 |
| AU518470B2 (en) | 1981-10-01 |
| NO792119L (no) | 1979-12-28 |
| US4293556A (en) | 1981-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |