PH15864A - 2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof - Google Patents

2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof

Info

Publication number
PH15864A
PH15864A PH24730A PH24730A PH15864A PH 15864 A PH15864 A PH 15864A PH 24730 A PH24730 A PH 24730A PH 24730 A PH24730 A PH 24730A PH 15864 A PH15864 A PH 15864A
Authority
PH
Philippines
Prior art keywords
methyl
salts
benzomorphans
alkoxy
hydroxy
Prior art date
Application number
PH24730A
Other languages
English (en)
Inventor
Herbert Merz
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of PH15864A publication Critical patent/PH15864A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH24730A 1978-06-26 1980-10-15 2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof PH15864A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782828039 DE2828039A1 (de) 1978-06-26 1978-06-26 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
PH15864A true PH15864A (en) 1983-04-13

Family

ID=6042819

Family Applications (1)

Application Number Title Priority Date Filing Date
PH24730A PH15864A (en) 1978-06-26 1980-10-15 2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof

Country Status (19)

Country Link
US (1) US4293556A (enEXAMPLES)
EP (1) EP0006449B1 (enEXAMPLES)
JP (1) JPS5513278A (enEXAMPLES)
AT (1) ATE1947T1 (enEXAMPLES)
AU (1) AU518470B2 (enEXAMPLES)
CA (1) CA1107280A (enEXAMPLES)
DE (2) DE2828039A1 (enEXAMPLES)
DK (1) DK156719C (enEXAMPLES)
ES (1) ES481873A1 (enEXAMPLES)
FI (1) FI65064C (enEXAMPLES)
GR (1) GR69233B (enEXAMPLES)
IE (1) IE48430B1 (enEXAMPLES)
IL (1) IL57648A (enEXAMPLES)
MX (1) MX5680E (enEXAMPLES)
NO (1) NO149888C (enEXAMPLES)
NZ (1) NZ190816A (enEXAMPLES)
PH (1) PH15864A (enEXAMPLES)
PT (1) PT69823A (enEXAMPLES)
ZA (1) ZA793150B (enEXAMPLES)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
GB2144639B (en) * 1983-08-11 1986-10-15 Edward Carden Jetting tube for use in micro-laryngeal surgery
JPS61294094A (ja) * 1985-06-24 1986-12-24 東洋ベントナイト株式会社 シ−ルド堀進に於ける裏込補助工法
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
JPH05312414A (ja) * 1992-05-12 1993-11-22 Yukimatsu Fujimoto 集熱器二段の太陽熱温水器
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
JP5470557B2 (ja) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
JP5769970B2 (ja) 2007-11-16 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用
EP2229368A1 (en) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291371B1 (en) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102089300B (zh) 2008-05-01 2014-06-18 生命医药公司 11β-羟基类固醇脱氢酶1的环状抑制剂
JP5711115B2 (ja) 2008-05-13 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417094A (en) * 1965-05-05 1968-12-17 Geigy Chem Corp Optically active 1,2,3,4,5,6-hexahydro-6-phenyl - 2,6 - methano - 3 - benzazocines an
NL132138C (enEXAMPLES) * 1966-05-20
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
BR6914879D0 (pt) * 1969-01-23 1973-02-08 Merck & Co Inc Processos quimicos
JPS55383B2 (enEXAMPLES) * 1971-09-13 1980-01-08
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates

Also Published As

Publication number Publication date
GR69233B (enEXAMPLES) 1982-05-10
NZ190816A (en) 1980-11-28
DK156719C (da) 1990-02-19
NO149888B (no) 1984-04-02
DE2828039A1 (de) 1980-01-10
ATE1947T1 (de) 1982-12-15
EP0006449B1 (de) 1982-12-08
AU4832779A (en) 1980-01-03
IE791189L (en) 1979-12-26
NO149888C (no) 1984-07-11
PT69823A (de) 1979-07-01
NO792119L (no) 1979-12-28
EP0006449A1 (de) 1980-01-09
DE2964196D1 (en) 1983-01-13
FI65064B (fi) 1983-11-30
US4293556A (en) 1981-10-06
JPS5513278A (en) 1980-01-30
IL57648A (en) 1984-01-31
MX5680E (es) 1983-12-08
ES481873A1 (es) 1980-02-16
IE48430B1 (en) 1985-01-23
FI792005A7 (fi) 1979-12-27
CA1107280A (en) 1981-08-18
DK266179A (da) 1979-12-27
AU518470B2 (en) 1981-10-01
JPH0159271B2 (enEXAMPLES) 1989-12-15
IL57648A0 (en) 1979-10-31
FI65064C (fi) 1984-03-12
ZA793150B (en) 1981-03-25
DK156719B (da) 1989-09-25

Similar Documents

Publication Publication Date Title
PH15864A (en) 2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof
WO1988000042A1 (en) New 5-alkoxy-2,4-diamino-alkyl benzols, and hair tinting means using them
GB2081264B (en) 5,10-dihydro-11h-dibenzo(b,e)(1,4)-diazepine-11-ones
ZA816259B (en) 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NO840037L (no) Cykloalifatiske farmasoeytiske forbindelser
ES477785A1 (es) Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas.
GB8322164D0 (en) Chemical compounds
DE2962919D1 (en) 2,4,6-triiodo-isophthalamic acid derivatives, their preparation and x-ray contrast agents based on these compounds
GB2019843A (en) N-Alkenylmoranoline derivatives
ES480391A1 (es) Un procedimiento para la preparacion de derivados de difeni-lamina.
IL58999A0 (en) Pharmaceutical compositions comprising certain imidazolinederivatives
GB2017689A (en) Substituted N- Iminomethylpiperidines
SE8303569D0 (sv) Polyprenylforeningar
ZA807905B (en) 2-phenylamino-imidazolines-(2),compositions thereof and process for the preparation thereof
IE780742L (en) Isoxazolylmethyl-benzomorphanes
GR75072B (enEXAMPLES)
ZA825933B (en) N-substituted-tetrahydroisophthalimide derivatives
ES458810A1 (es) Procedimiento para la preparacion de nuevos 2-(4-fenil-4- cianobutil)-1,2,3,4-tetrahidro-5(h)pirido(4,3-b)-indoles.
DE3660546D1 (en) Phosphoroimidates
GB2022583A (en) New ionic polyiodo benzene derivatives useful as X-ray contrast media