ES479423A1 - Procedimiento para la preparacion de 2-2-tenoiltio-propio- nil-glicina. - Google Patents
Procedimiento para la preparacion de 2-2-tenoiltio-propio- nil-glicina.Info
- Publication number
- ES479423A1 ES479423A1 ES479423A ES479423A ES479423A1 ES 479423 A1 ES479423 A1 ES 479423A1 ES 479423 A ES479423 A ES 479423A ES 479423 A ES479423 A ES 479423A ES 479423 A1 ES479423 A1 ES 479423A1
- Authority
- ES
- Spain
- Prior art keywords
- propionylglycine
- compound
- thenolythio
- preparation
- pharmaceutical formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
Abstract
Procedimiento para la preparación de 2-(2-tenoiltio)-propionilglicina, de fórmula (I) **(Fórmula)** o una de sus sales farmacéuticamente aceptables, que constituye el principio activo en composiciones farmacéuticas para la terapéutica de hematopatías agudas y crónicas y de resultados de intoxicaciones y en composiciones de actividad mucolítica y antibroncoespástica, caracterizado por hacerse reaccionar la 2-tiopropionilglicina con cloruro del ácido tiofen-2-carboxílico en presencia de una base.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22175/78A IT1095386B (it) | 1978-04-11 | 1978-04-11 | 2-(2-tenciltio)-propionilglicina,metodo per la sua preparazione e composizioni farmaceutiche che la contengono |
IT2011179A IT1166627B (it) | 1979-02-12 | 1979-02-12 | Impiego della 2-(2-tenoiltio)-propionilglicina in qualita' di agente mucolitico e antibroncospastico |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479423A1 true ES479423A1 (es) | 1979-11-01 |
Family
ID=26327401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479423A Expired ES479423A1 (es) | 1978-04-11 | 1979-04-09 | Procedimiento para la preparacion de 2-2-tenoiltio-propio- nil-glicina. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4242354A (es) |
JP (1) | JPS5910673B2 (es) |
AR (1) | AR219379A1 (es) |
AT (1) | AT374194B (es) |
CA (1) | CA1121825A (es) |
CH (1) | CH639380A5 (es) |
DE (1) | DE2913211C2 (es) |
DK (1) | DK148117C (es) |
ES (1) | ES479423A1 (es) |
FR (1) | FR2422657A1 (es) |
GB (1) | GB2018756B (es) |
IE (1) | IE47946B1 (es) |
LU (1) | LU81132A1 (es) |
NL (1) | NL7902700A (es) |
NO (1) | NO149312C (es) |
SE (1) | SE444940B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1149884B (it) * | 1980-06-03 | 1986-12-10 | Btb Ind Chimica | Prozedimento per la preparazione della n-(2-tenoil)tiopropionil)-glicina |
IT1148890B (it) * | 1980-07-22 | 1986-12-03 | Neopharmed Spa | Derivato della teonil tiopropionil glicina e procedimento per la sua preparazione |
US4415681A (en) * | 1980-10-23 | 1983-11-15 | Ford Motor Company | Stabilized crosslinked dispersion |
FR2502627A1 (fr) * | 1981-02-02 | 1982-10-01 | Refarmed Sa | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent |
IT1143209B (it) * | 1981-07-02 | 1986-10-22 | Sigma Tau Ind Farmaceuti | Esteri della 2-tenoilmercaptopropionil glicina con idrossibenzeni sostituiti procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
IE52884B1 (en) * | 1981-05-11 | 1988-03-30 | Sigma Tau Ind Farmaceuti | 2-methoxyphenyl esters of n-substituted amino acids, their preparation and pharmaceutical use |
FR2521146B1 (fr) * | 1983-02-02 | 1985-10-25 | Sigma Tau Ind Farmaceuti | Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation, et produits pharmaceutiques dans lesquels ils apparaissent |
IT1212723B (it) * | 1983-03-23 | 1989-11-30 | Medea Res Srl | Derivato dell'acido tiolattico ad attivita'broncosecretogoga. |
JPS59191971U (ja) * | 1983-06-08 | 1984-12-20 | 有限会社 沢田久商店 | 枕 |
JPS60152786U (ja) * | 1984-03-21 | 1985-10-11 | 三協アルミニウム工業株式会社 | サツシ枠取外し装置 |
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
ES2039260T3 (es) * | 1987-02-05 | 1993-09-16 | Farmaceutici Caber S.P.A. | Derivado de 4-oxo-1,3-benzodioxano. |
JPS63199669U (es) * | 1987-05-22 | 1988-12-22 | ||
US6349719B2 (en) | 1997-02-24 | 2002-02-26 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
US6192882B1 (en) * | 1997-02-24 | 2001-02-27 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
JP5705314B2 (ja) * | 2010-07-02 | 2015-04-22 | ギリアード サイエンシーズ, インコーポレイテッド | アポトーシスシグナル調節キナーゼ阻害剤 |
CN106008456A (zh) * | 2016-06-27 | 2016-10-12 | 山东川成医药股份有限公司 | 一种司替罗宁的制备方法 |
WO2022250957A2 (en) * | 2021-05-10 | 2022-12-01 | Altibio, Inc. | Thioester prodrugs for the treatment of renal anomalies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2510773A (en) * | 1946-05-18 | 1950-06-06 | Sterling Drug Inc | Process for preparing a tertiary amino-alkyl thiol-ester hydrochloride |
US2632735A (en) * | 1951-03-01 | 1953-03-24 | Standard Oil Dev Co | Lubricating oil additives |
US2669564A (en) * | 1951-03-17 | 1954-02-16 | Sterling Drug Inc | Tertiary-aminoalkyl 4-amino-2-alkoxy-thiolbenzoates and their preparation |
FR2338701A1 (fr) * | 1976-01-23 | 1977-08-19 | Blum Jean | Nouveaux derives de la cysteine |
-
1979
- 1979-03-26 CA CA000324110A patent/CA1121825A/en not_active Expired
- 1979-03-27 FR FR7907633A patent/FR2422657A1/fr active Granted
- 1979-04-03 DE DE2913211A patent/DE2913211C2/de not_active Expired
- 1979-04-04 AT AT0249879A patent/AT374194B/de not_active IP Right Cessation
- 1979-04-04 CH CH318279A patent/CH639380A5/it not_active IP Right Cessation
- 1979-04-04 US US06/026,933 patent/US4242354A/en not_active Expired - Lifetime
- 1979-04-05 AR AR276092A patent/AR219379A1/es active
- 1979-04-05 NL NL7902700A patent/NL7902700A/xx not_active Application Discontinuation
- 1979-04-06 SE SE7903105A patent/SE444940B/sv not_active IP Right Cessation
- 1979-04-09 ES ES479423A patent/ES479423A1/es not_active Expired
- 1979-04-09 LU LU81132A patent/LU81132A1/xx unknown
- 1979-04-10 NO NO791205A patent/NO149312C/no unknown
- 1979-04-11 DK DK153179A patent/DK148117C/da not_active IP Right Cessation
- 1979-04-11 GB GB7912768A patent/GB2018756B/en not_active Expired
- 1979-04-11 JP JP54044827A patent/JPS5910673B2/ja not_active Expired
- 1979-08-08 IE IE788/79A patent/IE47946B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
LU81132A1 (fr) | 1979-06-19 |
SE444940B (sv) | 1986-05-20 |
CH639380A5 (it) | 1983-11-15 |
JPS54141761A (en) | 1979-11-05 |
FR2422657A1 (fr) | 1979-11-09 |
IE47946B1 (en) | 1984-07-25 |
DE2913211A1 (de) | 1979-10-25 |
FR2422657B1 (es) | 1981-10-23 |
AR219379A1 (es) | 1980-08-15 |
NO149312B (no) | 1983-12-19 |
NO791205L (no) | 1979-10-12 |
IE790788L (en) | 1979-10-11 |
ATA249879A (de) | 1983-08-15 |
NO149312C (no) | 1984-03-28 |
DK148117C (da) | 1985-08-26 |
GB2018756B (en) | 1982-10-13 |
CA1121825A (en) | 1982-04-13 |
US4242354A (en) | 1980-12-30 |
NL7902700A (nl) | 1979-10-15 |
GB2018756A (en) | 1979-10-24 |
AT374194B (de) | 1984-03-26 |
DK153179A (da) | 1979-10-12 |
SE7903105L (sv) | 1979-10-12 |
DK148117B (da) | 1985-03-11 |
DE2913211C2 (de) | 1982-05-06 |
JPS5910673B2 (ja) | 1984-03-10 |
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