ES474611A1 - Procedimiento para aislar y purificar fosfato de poliribosilribitol inmunologicamente activo - Google Patents
Procedimiento para aislar y purificar fosfato de poliribosilribitol inmunologicamente activoInfo
- Publication number
- ES474611A1 ES474611A1 ES474611A ES474611A ES474611A1 ES 474611 A1 ES474611 A1 ES 474611A1 ES 474611 A ES474611 A ES 474611A ES 474611 A ES474611 A ES 474611A ES 474611 A1 ES474611 A1 ES 474611A1
- Authority
- ES
- Spain
- Prior art keywords
- prp
- immunologically active
- antibody
- obtainable
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229910019142 PO4 Inorganic materials 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 241000588832 Bordetella pertussis Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical class [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 abstract 1
- VJDOAZKNBQCAGE-LMVFSUKVSA-N D-ribitol 5-phosphate Chemical compound OC[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O VJDOAZKNBQCAGE-LMVFSUKVSA-N 0.000 abstract 1
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000010923 batch production Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/846,466 US4196192A (en) | 1977-10-28 | 1977-10-28 | Combined Haemophilus influenzae type b and pertussis vaccine |
| US05/846,488 US4220717A (en) | 1977-12-22 | 1977-12-22 | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES474611A1 true ES474611A1 (es) | 1980-01-16 |
Family
ID=27126641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES474611A Expired ES474611A1 (es) | 1977-10-28 | 1978-10-27 | Procedimiento para aislar y purificar fosfato de poliribosilribitol inmunologicamente activo |
Country Status (25)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE889979A (fr) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| CA1209036A (en) * | 1982-08-20 | 1986-08-05 | Joseph S.C. Kuo | Combined haemophilus influenzae and diphtheria, pertussis, tetanus vaccine |
| US4744982A (en) * | 1982-08-24 | 1988-05-17 | Hunter Kenneth W | Human monoclonal antibody reactive with polyribosylribitol phosphate |
| IL98715A0 (en) * | 1990-08-13 | 1992-07-15 | American Cyanamid Co | Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines |
| WO1993004183A1 (en) * | 1991-08-16 | 1993-03-04 | Merck & Co., Inc. | Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide |
| ATE176157T1 (de) * | 1992-10-27 | 1999-02-15 | American Cyanamid Co | Pädiatrische kombinationsvakzine mit verbesserter immunogenizität jeder vakzine komponente |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3395219A (en) * | 1964-12-11 | 1968-07-30 | Merck & Co Inc | Process for production of pertussis antigen |
| IL24946A (en) * | 1965-01-19 | 1969-05-28 | Merck & Co Inc | Process for preparing antibodies in cilus pertussis |
| US3465078A (en) * | 1965-10-21 | 1969-09-02 | Sydney Z Spiesel | Method of recovering antigens from bordetella pertussis cells |
| NL174267B (nl) * | 1969-05-20 | Roussel Uclaf | Verbetering van de werkwijze voor de bereiding van een somatisch antigeen volgens het nederlandse octrooischrift 169754 en werkwijze ter bereiding van een farmaceutisch preparaat. | |
| US3636192A (en) * | 1970-01-13 | 1972-01-18 | Us Army | Meningococcal polysaccharide vaccines |
| FR2253499B1 (enrdf_load_stackoverflow) * | 1973-12-10 | 1977-11-04 | Fabre Sa Pierre | |
| DE2461439C3 (de) * | 1974-12-24 | 1980-03-20 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung eines schützenden Antigens von Bordetella Pertussis sowie jenes enthaltendes Mittel |
| US3978209A (en) * | 1975-03-24 | 1976-08-31 | Merck & Co., Inc. | Endotoxin free meningococcus polysaccharides |
-
1978
- 1978-08-22 NZ NZ188211A patent/NZ188211A/en unknown
- 1978-08-25 IL IL55433A patent/IL55433A/xx unknown
- 1978-08-29 CA CA000310218A patent/CA1117866A/en not_active Expired
- 1978-08-30 AR AR273492A patent/AR218932A1/es active
- 1978-08-30 GR GR57127A patent/GR73991B/el unknown
- 1978-10-20 DE DE19782845745 patent/DE2845745A1/de active Granted
- 1978-10-24 IT IT51621/78A patent/IT1107570B/it active
- 1978-10-25 PH PH21738A patent/PH15882A/en unknown
- 1978-10-26 FI FI783269A patent/FI63674C/fi not_active IP Right Cessation
- 1978-10-26 AU AU41081/78A patent/AU520902B2/en not_active Expired
- 1978-10-26 FR FR7830517A patent/FR2407000B1/fr not_active Expired
- 1978-10-27 PL PL21054578A patent/PL210545A1/xx unknown
- 1978-10-27 DK DK479578A patent/DK154327C/da not_active IP Right Cessation
- 1978-10-27 SE SE7811192A patent/SE430753B/sv not_active IP Right Cessation
- 1978-10-27 GB GB7842230A patent/GB2007244B/en not_active Expired
- 1978-10-27 NL NL7810753A patent/NL7810753A/xx not_active Application Discontinuation
- 1978-10-27 YU YU02508/78A patent/YU250878A/xx unknown
- 1978-10-27 ES ES474611A patent/ES474611A1/es not_active Expired
- 1978-10-27 NO NO783635A patent/NO149611C/no unknown
- 1978-10-27 IE IE2146/78A patent/IE47474B1/en unknown
- 1978-10-27 CH CH11125/78A patent/CH649781A5/de not_active IP Right Cessation
- 1978-10-27 HU HU78AE546A patent/HU178166B/hu not_active IP Right Cessation
- 1978-10-27 BE BE191385A patent/BE871586A/xx not_active IP Right Cessation
- 1978-10-27 DD DD78208715A patent/DD140701A5/de unknown
- 1978-10-28 JP JP13310978A patent/JPS5480408A/ja active Granted
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