ES474232A1 - Un metodo para producir 2,6-diaminonebularinas - Google Patents
Un metodo para producir 2,6-diaminonebularinasInfo
- Publication number
- ES474232A1 ES474232A1 ES474232A ES474232A ES474232A1 ES 474232 A1 ES474232 A1 ES 474232A1 ES 474232 A ES474232 A ES 474232A ES 474232 A ES474232 A ES 474232A ES 474232 A1 ES474232 A1 ES 474232A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- image
- group
- diaminonebularines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- RTRQQBHATOEIAF-UUOKFMHZSA-N acadesine Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RTRQQBHATOEIAF-UUOKFMHZSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un método para producir 2,6-diaminobularinas de la fórmula **fórmula** en la que R es un grupo fenilo o ciclohexilo que puede estar sustituido con halógeno, alcohilo inferior o alcoxi inferior, o su sal de adición de ácido, que comprende someter 5-.amino-1- beta-D-ribofuranosilimidazol-4-carboxamida a una reacción para proteger sus grupos hidroxilo, someter el compuesto resultante protegido en hidroxilo a una reacción de deshidratación para dar un compuesto de la fórmula**fórmula** en la que R1'', R2'' y R3'' independientemente unos de otros, son un grupo hidroxilo protegido, hacer reaccionar el último compuesto mencionado con un compuesto de la fórmula R-N=C=N-R4 en la que R tiene el mismo significado que se ha definido arriba y R4 es hidrógeno o el migro grupo que R, bien sea después de un tratamiento previo para separación de los grupos protectores o sin tal tratamiento, y si es necesario, someter el compuesto resultante a un tratamiento para separación de los grupos protectores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12714777A JPS5461194A (en) | 1977-10-21 | 1977-10-21 | Preparation of n22substituted 2*66diaminonebularin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES474232A1 true ES474232A1 (es) | 1979-11-01 |
Family
ID=14952769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES474232A Expired ES474232A1 (es) | 1977-10-21 | 1978-10-16 | Un metodo para producir 2,6-diaminonebularinas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4255565A (es) |
| JP (1) | JPS5461194A (es) |
| AT (1) | AT363619B (es) |
| AU (1) | AU521358B2 (es) |
| BE (1) | BE871422A (es) |
| CA (1) | CA1102794A (es) |
| DE (1) | DE2845435A1 (es) |
| DK (1) | DK465578A (es) |
| ES (1) | ES474232A1 (es) |
| FI (1) | FI783181A7 (es) |
| FR (1) | FR2406640A1 (es) |
| GB (1) | GB2007664B (es) |
| GR (1) | GR65350B (es) |
| IL (1) | IL55732A0 (es) |
| IT (1) | IT1101612B (es) |
| LU (1) | LU80402A1 (es) |
| NL (1) | NL7810519A (es) |
| NO (1) | NO783559L (es) |
| NZ (1) | NZ188713A (es) |
| PT (1) | PT68686A (es) |
| SE (1) | SE7810854L (es) |
| ZA (1) | ZA785762B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55130998A (en) * | 1979-04-02 | 1980-10-11 | Takeda Chem Ind Ltd | N2-substituted 2,6-diaminonebularin |
| JPS60193997A (ja) * | 1984-03-14 | 1985-10-02 | Sumitomo Chem Co Ltd | 新規シアノイミダゾ−ルリボヌクレオシド誘導体およびその製造法 |
| US5063233A (en) * | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4954504A (en) * | 1986-11-14 | 1990-09-04 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity |
| US4968697A (en) * | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| EP0704215A3 (en) | 1994-06-02 | 1998-04-01 | Takeda Chemical Industries, Ltd. | Inhibitor of vascular permeability enhancer |
| ES2192495B1 (es) * | 2002-03-21 | 2005-02-16 | Universidad De Barcelona | Nuevo uso terapeutico del ribosido de 5-aminoimidazol-4-carboxamida (acadesina). |
| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305150D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305153D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Identification of therapeutic compounds |
| GB0305149D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| CA2557285A1 (en) * | 2004-03-05 | 2005-09-15 | Cambridge Biotechnology Limited | Adenosine receptor agonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1050892A (es) * | 1900-01-01 | |||
| US3787544A (en) * | 1959-04-24 | 1974-01-22 | S Barnette | Method of making plastic articles with a partially enveloped core |
| FR1535561A (fr) * | 1966-06-18 | 1968-08-09 | Ajinomoto Kk | Méthode de préparation de l'adénine, de ses dérivés et intermédiaires |
| DE1670242A1 (de) * | 1967-07-01 | 1971-01-28 | Boehringer Mannheim Gmbh | Neue Nebularin-Derivate und Verfahren zu deren Herstellung |
| GB1390015A (en) | 1971-05-07 | 1975-04-09 | Koninklijke Pharma Fab Nv | 4-amino-quinazoline compounds |
| DE2359536C2 (de) * | 1972-12-08 | 1984-08-02 | Takeda Chemical Industries, Ltd., Osaka | 2,6-Diaminonebularinderivate |
| DE2455634C2 (de) * | 1973-11-24 | 1983-08-18 | Yasuro Ito | Verfahren und Vorrichtung zum Herstellen von Betonkörpern |
| AT337952B (de) * | 1975-04-28 | 1977-07-25 | Voest Ag | Leichtbauplatte |
-
1977
- 1977-10-21 JP JP12714777A patent/JPS5461194A/ja active Pending
-
1978
- 1978-10-05 GR GR57381A patent/GR65350B/el unknown
- 1978-10-06 GB GB7839583A patent/GB2007664B/en not_active Expired
- 1978-10-09 AU AU40511/78A patent/AU521358B2/en not_active Expired
- 1978-10-12 ZA ZA00785762A patent/ZA785762B/xx unknown
- 1978-10-13 IL IL7855732A patent/IL55732A0/xx unknown
- 1978-10-13 CA CA313,340A patent/CA1102794A/en not_active Expired
- 1978-10-16 ES ES474232A patent/ES474232A1/es not_active Expired
- 1978-10-18 SE SE7810854A patent/SE7810854L/xx unknown
- 1978-10-18 FI FI783181A patent/FI783181A7/fi unknown
- 1978-10-19 IT IT28929/78A patent/IT1101612B/it active
- 1978-10-19 DK DK465578A patent/DK465578A/da unknown
- 1978-10-19 DE DE19782845435 patent/DE2845435A1/de not_active Withdrawn
- 1978-10-20 NL NL7810519A patent/NL7810519A/xx not_active Application Discontinuation
- 1978-10-20 NZ NZ188713A patent/NZ188713A/xx unknown
- 1978-10-20 PT PT68686A patent/PT68686A/pt unknown
- 1978-10-20 NO NO783559A patent/NO783559L/no unknown
- 1978-10-20 FR FR7829945A patent/FR2406640A1/fr active Granted
- 1978-10-20 US US05/953,255 patent/US4255565A/en not_active Expired - Lifetime
- 1978-10-20 AT AT0755278A patent/AT363619B/de not_active IP Right Cessation
- 1978-10-20 BE BE191251A patent/BE871422A/xx unknown
- 1978-10-20 LU LU80402A patent/LU80402A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7810519A (nl) | 1979-04-24 |
| AU4051178A (en) | 1980-04-17 |
| JPS5461194A (en) | 1979-05-17 |
| FI783181A7 (fi) | 1979-04-22 |
| PT68686A (fr) | 1978-11-01 |
| FR2406640A1 (fr) | 1979-05-18 |
| GB2007664A (en) | 1979-05-23 |
| IT7828929A0 (it) | 1978-10-19 |
| GR65350B (en) | 1980-08-18 |
| LU80402A1 (fr) | 1979-03-19 |
| FR2406640B1 (es) | 1982-05-28 |
| NZ188713A (en) | 1981-07-13 |
| IT1101612B (it) | 1985-10-07 |
| BE871422A (fr) | 1979-04-20 |
| ATA755278A (de) | 1981-01-15 |
| NO783559L (no) | 1979-04-24 |
| DE2845435A1 (de) | 1979-04-26 |
| SE7810854L (sv) | 1979-04-22 |
| ZA785762B (en) | 1979-09-26 |
| DK465578A (da) | 1979-04-22 |
| AT363619B (de) | 1981-08-25 |
| AU521358B2 (en) | 1982-04-01 |
| CA1102794A (en) | 1981-06-09 |
| US4255565A (en) | 1981-03-10 |
| GB2007664B (en) | 1982-05-26 |
| IL55732A0 (en) | 1978-12-17 |
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