ES469287A1 - Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas - Google Patents
Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinasInfo
- Publication number
- ES469287A1 ES469287A1 ES469287A ES469287A ES469287A1 ES 469287 A1 ES469287 A1 ES 469287A1 ES 469287 A ES469287 A ES 469287A ES 469287 A ES469287 A ES 469287A ES 469287 A1 ES469287 A1 ES 469287A1
- Authority
- ES
- Spain
- Prior art keywords
- cephalosporins
- oxa
- dethia
- arylmalonamido
- broad
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para preparar arilzamonamido-1-oxadestiacefalosporinas compuesto en el que COB1 y/o COB3 son carboxilo protegido, operando conforme a alguno de los modos siguientes u otros similares: 1) hidrolizando ésteres, amidas y anhídridos altamente reactivos con un ácido o una base; 2) escidiendo los ésteres de 2-haloetilo, bencilo, metilbencilo, nitrobencilo y diarilmetilo por reducción suave (por ej. con sales de estaño, zinc o cromo divalente en presencia de ácidos, ditionito de sodio; hidrogenación catalítica con hidrógeno sobre catalizador, por ej. de platino, paladio o níquel); 3) escidiendo los ésteres de bencilo, metoxibencilo, metilbencilo, dimetoxibencilo, terc-alcohilo, tritilo, diarilmetilo y ciclopropil-metilo por acción de ácidos o por solvolisis (por ej. con ácidos minerales tales como ácido clorhídrico, ácidos de Lewis, por ej. cloruro de aluminio, ácidos sulfónicos, por ej. ácido p-toluensulfónico, ácidos carboxílicos, fuertemente ácidos, por ej. ácido trifluoroacético, ácido fórmico, si se requiere en presencia de un aceptor de cationes, por ej. anisol); y 4) escindiendo los ésteres de fenacilo, etinilo, p-hidroxi-3,5-di-terc-butilbencilo por acción de una base (por ej. tiofenócidos de metal alcalino, base inorgánica, sales básicas).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3340176A JPS52122386A (en) | 1976-03-25 | 1976-03-25 | Cephalosporin analogous compounds as antibacterials |
JP5029576A JPS52133997A (en) | 1976-04-30 | 1976-04-30 | Cephalosporin antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
ES469287A1 true ES469287A1 (es) | 1979-09-16 |
Family
ID=26372085
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES457174A Expired ES457174A1 (es) | 1976-03-25 | 1977-03-24 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
ES469286A Expired ES469286A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas |
ES469287A Expired ES469287A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
ES469285A Expired ES469285A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
ES469284A Expired ES469284A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES457174A Expired ES457174A1 (es) | 1976-03-25 | 1977-03-24 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
ES469286A Expired ES469286A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES469285A Expired ES469285A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
ES469284A Expired ES469284A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
Country Status (19)
Country | Link |
---|---|
AR (1) | AR224606A1 (es) |
BG (1) | BG31074A3 (es) |
CY (1) | CY1158A (es) |
DD (1) | DD129792A5 (es) |
DE (1) | DE2713370C2 (es) |
DK (1) | DK161331C (es) |
ES (5) | ES457174A1 (es) |
GR (1) | GR61146B (es) |
HK (1) | HK46882A (es) |
HU (1) | HU172720B (es) |
IE (1) | IE44794B1 (es) |
IL (1) | IL51743A (es) |
MX (1) | MX4348E (es) |
NO (2) | NO158505C (es) |
NZ (1) | NZ183687A (es) |
PT (1) | PT66346B (es) |
RO (2) | RO71742A (es) |
SE (1) | SE443143B (es) |
YU (2) | YU44039B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1557552A (en) * | 1977-02-15 | 1979-12-12 | Shionogi & Co | 1 oxadethiacepham compounds |
US4252953A (en) * | 1979-05-01 | 1981-02-24 | Eli Lilly And Company | Antibiotic crystalline epimer |
JPS60123490A (ja) * | 1983-12-07 | 1985-07-02 | Shionogi & Co Ltd | マロニルオキサセフェムカルボン酸誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL178005C (nl) * | 1972-11-06 | 1986-01-02 | Merck & Co Inc | Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum. |
US3962232A (en) * | 1973-11-05 | 1976-06-08 | Eli Lilly And Company | 7-methoxycephalosporins |
GB1449420A (en) * | 1973-11-26 | 1976-09-15 | Sankyo Co | 7alpha-methoxycephalosporing derivatives |
-
1977
- 1977-03-23 GR GR53086A patent/GR61146B/el unknown
- 1977-03-23 CY CY1158A patent/CY1158A/xx unknown
- 1977-03-23 SE SE7703325A patent/SE443143B/xx not_active IP Right Cessation
- 1977-03-23 NO NO771023A patent/NO158505C/no unknown
- 1977-03-24 PT PT66346A patent/PT66346B/pt unknown
- 1977-03-24 IE IE622/77A patent/IE44794B1/en not_active IP Right Cessation
- 1977-03-24 ES ES457174A patent/ES457174A1/es not_active Expired
- 1977-03-24 RO RO7789781A patent/RO71742A/ro unknown
- 1977-03-24 NZ NZ183687A patent/NZ183687A/xx unknown
- 1977-03-24 BG BG7735796A patent/BG31074A3/xx unknown
- 1977-03-24 RO RO7799076A patent/RO78228A/ro unknown
- 1977-03-24 DD DD7700198053A patent/DD129792A5/xx unknown
- 1977-03-24 HU HU77SI00001565A patent/HU172720B/hu not_active IP Right Cessation
- 1977-03-24 DK DK131277A patent/DK161331C/da not_active IP Right Cessation
- 1977-03-25 IL IL51743A patent/IL51743A/xx unknown
- 1977-03-25 DE DE2713370A patent/DE2713370C2/de not_active Expired - Lifetime
- 1977-03-25 MX MX775582U patent/MX4348E/es unknown
- 1977-03-25 AR AR266992A patent/AR224606A1/es active
-
1978
- 1978-04-28 ES ES469286A patent/ES469286A1/es not_active Expired
- 1978-04-28 ES ES469287A patent/ES469287A1/es not_active Expired
- 1978-04-28 ES ES469285A patent/ES469285A1/es not_active Expired
- 1978-04-28 ES ES469284A patent/ES469284A1/es not_active Expired
-
1982
- 1982-11-11 HK HK468/82A patent/HK46882A/xx unknown
-
1983
- 1983-08-23 YU YU1738/83A patent/YU44039B/xx unknown
- 1983-08-23 YU YU1737/83A patent/YU44038B/xx unknown
-
1986
- 1986-05-28 NO NO862107A patent/NO862107L/no unknown
Also Published As
Publication number | Publication date |
---|---|
DE2713370A1 (de) | 1977-09-29 |
HU172720B (hu) | 1978-11-28 |
HK46882A (en) | 1982-11-19 |
DE2713370C2 (de) | 1994-04-21 |
ES469286A1 (es) | 1979-09-16 |
YU44038B (en) | 1990-02-28 |
NZ183687A (en) | 1979-01-11 |
YU173883A (en) | 1983-12-31 |
YU173783A (en) | 1983-12-31 |
DD129792A5 (de) | 1978-02-08 |
RO78228A (ro) | 1982-02-01 |
SE7703325L (sv) | 1977-09-26 |
CY1158A (en) | 1983-01-28 |
SE443143B (sv) | 1986-02-17 |
DK161331B (da) | 1991-06-24 |
NO862107L (no) | 1977-09-27 |
IE44794L (en) | 1977-09-25 |
GR61146B (en) | 1978-09-27 |
NO158505B (no) | 1988-06-13 |
MX4348E (es) | 1982-04-05 |
PT66346B (en) | 1978-08-16 |
YU44039B (en) | 1990-02-28 |
AR224606A1 (es) | 1981-12-30 |
RO71742A (ro) | 1982-02-26 |
PT66346A (en) | 1977-04-01 |
DK161331C (da) | 1991-12-09 |
ES457174A1 (es) | 1978-08-16 |
NO771023L (no) | 1977-09-27 |
DK131277A (da) | 1977-09-26 |
ES469284A1 (es) | 1978-11-16 |
ES469285A1 (es) | 1979-09-16 |
IL51743A (en) | 1980-10-26 |
IE44794B1 (en) | 1982-04-07 |
BG31074A3 (en) | 1981-10-15 |
NO158505C (no) | 1988-09-21 |
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