ES469285A1 - Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas - Google Patents

Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas

Info

Publication number
ES469285A1
ES469285A1 ES469285A ES469285A ES469285A1 ES 469285 A1 ES469285 A1 ES 469285A1 ES 469285 A ES469285 A ES 469285A ES 469285 A ES469285 A ES 469285A ES 469285 A1 ES469285 A1 ES 469285A1
Authority
ES
Spain
Prior art keywords
cephalosporins
oxa
dethia
arylmalonamido
broad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469285A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3340176A external-priority patent/JPS52122386A/ja
Priority claimed from JP5029576A external-priority patent/JPS52133997A/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES469285A1 publication Critical patent/ES469285A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En la presente invención se han preparado ahora varias 1-oxadestiacefalo sporinas estrechamente relacionadas con las (1-tia)-cefalo sporinas conocidas. Contrariamente a los informes que sugieren que sus 1-oxacefalo sporinas racémicas mostraban alrededor de la mitad de la potencia de la (1-tia)cefalo sporinas, los productos ópticamente activos preparados en la presente invención fueron de alrededor de 4 a 8 veces más activos que las correspondientes (1-tia)cefalo sporinas en cuanto a sus propiedades antibacterianas. Sin embargo, el anillo de beta-lactama de las 1-oxadestiacefalo sporinas era menos estable para uso como medicamentos clínicos que el de las (1-tia)cefalo sporinas. Los compuestos seleccionados de entre los compuestos ópticamente activos preparados en la presente invención, resuelven la deficiencia citada de las 1-oxadestiacefalo sporinas.
ES469285A 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas Expired ES469285A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3340176A JPS52122386A (en) 1976-03-25 1976-03-25 Cephalosporin analogous compounds as antibacterials
JP5029576A JPS52133997A (en) 1976-04-30 1976-04-30 Cephalosporin antibiotics

Publications (1)

Publication Number Publication Date
ES469285A1 true ES469285A1 (es) 1979-09-16

Family

ID=26372085

Family Applications (5)

Application Number Title Priority Date Filing Date
ES457174A Expired ES457174A1 (es) 1976-03-25 1977-03-24 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas.
ES469286A Expired ES469286A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas
ES469287A Expired ES469287A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas
ES469285A Expired ES469285A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas
ES469284A Expired ES469284A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES457174A Expired ES457174A1 (es) 1976-03-25 1977-03-24 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas.
ES469286A Expired ES469286A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas
ES469287A Expired ES469287A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES469284A Expired ES469284A1 (es) 1976-03-25 1978-04-28 Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas.

Country Status (19)

Country Link
AR (1) AR224606A1 (es)
BG (1) BG31074A3 (es)
CY (1) CY1158A (es)
DD (1) DD129792A5 (es)
DE (1) DE2713370C2 (es)
DK (1) DK161331C (es)
ES (5) ES457174A1 (es)
GR (1) GR61146B (es)
HK (1) HK46882A (es)
HU (1) HU172720B (es)
IE (1) IE44794B1 (es)
IL (1) IL51743A (es)
MX (1) MX4348E (es)
NO (2) NO158505C (es)
NZ (1) NZ183687A (es)
PT (1) PT66346B (es)
RO (2) RO71742A (es)
SE (1) SE443143B (es)
YU (2) YU44039B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
US4252953A (en) * 1979-05-01 1981-02-24 Eli Lilly And Company Antibiotic crystalline epimer
JPS60123490A (ja) * 1983-12-07 1985-07-02 Shionogi & Co Ltd マロニルオキサセフェムカルボン酸誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
US3962232A (en) * 1973-11-05 1976-06-08 Eli Lilly And Company 7-methoxycephalosporins
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives

Also Published As

Publication number Publication date
DE2713370A1 (de) 1977-09-29
HU172720B (hu) 1978-11-28
HK46882A (en) 1982-11-19
DE2713370C2 (de) 1994-04-21
ES469286A1 (es) 1979-09-16
YU44038B (en) 1990-02-28
NZ183687A (en) 1979-01-11
YU173883A (en) 1983-12-31
YU173783A (en) 1983-12-31
DD129792A5 (de) 1978-02-08
RO78228A (ro) 1982-02-01
SE7703325L (sv) 1977-09-26
CY1158A (en) 1983-01-28
SE443143B (sv) 1986-02-17
DK161331B (da) 1991-06-24
NO862107L (no) 1977-09-27
IE44794L (en) 1977-09-25
ES469287A1 (es) 1979-09-16
GR61146B (en) 1978-09-27
NO158505B (no) 1988-06-13
MX4348E (es) 1982-04-05
PT66346B (en) 1978-08-16
YU44039B (en) 1990-02-28
AR224606A1 (es) 1981-12-30
RO71742A (ro) 1982-02-26
PT66346A (en) 1977-04-01
DK161331C (da) 1991-12-09
ES457174A1 (es) 1978-08-16
NO771023L (no) 1977-09-27
DK131277A (da) 1977-09-26
ES469284A1 (es) 1978-11-16
IL51743A (en) 1980-10-26
IE44794B1 (en) 1982-04-07
BG31074A3 (en) 1981-10-15
NO158505C (no) 1988-09-21

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