IE44794L - Arylmalonamido-1-oxadethia-cephalosporins - Google Patents

Arylmalonamido-1-oxadethia-cephalosporins

Info

Publication number
IE44794L
IE44794L IE770622A IE62277A IE44794L IE 44794 L IE44794 L IE 44794L IE 770622 A IE770622 A IE 770622A IE 62277 A IE62277 A IE 62277A IE 44794 L IE44794 L IE 44794L
Authority
IE
Ireland
Prior art keywords
cephalosporins
oxadethia
corresp
meo
het
Prior art date
Application number
IE770622A
Other languages
Unknown language ( )
Other versions
IE44794B1 (en
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3340176A external-priority patent/JPS52122386A/en
Priority claimed from JP5029576A external-priority patent/JPS52133997A/en
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of IE44794L publication Critical patent/IE44794L/en
Publication of IE44794B1 publication Critical patent/IE44794B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New 1-oxa-dethia-cephalosporins are of formula (I) (where Ar is 2- or 3-thienyl phenyl, p-hydroxyphenyl or p-acyloxyphenyl; COB, and COB2 are COOH or protected carboxy; Het is u-methyltetrazol-5-yl (MT), opt. protected 1-carboxymethyltetrazol-5-yl (CMT) or 2-methyl-1, 3, 4-thiadiazol-5-yl (MTD); Y is H or MeO; with the provido that Het must be MT when Y is MeO). (I) have 4-8 times the antibacterial activity of the corresp. true cephalosporins, esp. against Gram. neg. bacteria (including resistant Pseudomonas strains), and have better stability than known 1-oxa-dethiacephalosporins. A typical cpd. is diphenylmethyl 7 beta-(beta-phenyl-alpha-diphenylmethoxycarbonylacetamido)-3-(-1-t- hiomethyl)-1-oxadethia-3-cephem-4-carboxylate. In an example, this is prepd. by reacting the corresp. 7-amino cpd. with monodiphenylmethyl phenylmalonate. [DE2713370A1]
IE622/77A 1976-03-25 1977-03-24 Arylmalonamido-1-oxadethiacephalosporins IE44794B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3340176A JPS52122386A (en) 1976-03-25 1976-03-25 Cephalosporin analogous compounds as antibacterials
JP5029576A JPS52133997A (en) 1976-04-30 1976-04-30 Cephalosporin antibiotics

Publications (2)

Publication Number Publication Date
IE44794L true IE44794L (en) 1977-09-25
IE44794B1 IE44794B1 (en) 1982-04-07

Family

ID=26372085

Family Applications (1)

Application Number Title Priority Date Filing Date
IE622/77A IE44794B1 (en) 1976-03-25 1977-03-24 Arylmalonamido-1-oxadethiacephalosporins

Country Status (19)

Country Link
AR (1) AR224606A1 (en)
BG (1) BG31074A3 (en)
CY (1) CY1158A (en)
DD (1) DD129792A5 (en)
DE (1) DE2713370C2 (en)
DK (1) DK161331C (en)
ES (5) ES457174A1 (en)
GR (1) GR61146B (en)
HK (1) HK46882A (en)
HU (1) HU172720B (en)
IE (1) IE44794B1 (en)
IL (1) IL51743A (en)
MX (1) MX4348E (en)
NO (2) NO158505C (en)
NZ (1) NZ183687A (en)
PT (1) PT66346B (en)
RO (2) RO78228A (en)
SE (1) SE443143B (en)
YU (2) YU44038B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU514377B2 (en) * 1977-02-15 1981-02-05 Shionogi & Co., Ltd. l-OXADETHIACEPHAM COMPOUNDS
US4252953A (en) * 1979-05-01 1981-02-24 Eli Lilly And Company Antibiotic crystalline epimer
JPS60123490A (en) * 1983-12-07 1985-07-02 Shionogi & Co Ltd Malonyloxacephem carboxylic acid derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178005C (en) * 1972-11-06 1986-01-02 Merck & Co Inc METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL ACTION, AND METHOD FOR PREPARING A CEPHALOSPORINE ANTIBIOTIC.
US3962232A (en) * 1973-11-05 1976-06-08 Eli Lilly And Company 7-methoxycephalosporins
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives

Also Published As

Publication number Publication date
BG31074A3 (en) 1981-10-15
ES469284A1 (en) 1978-11-16
ES469286A1 (en) 1979-09-16
HK46882A (en) 1982-11-19
DK131277A (en) 1977-09-26
YU44038B (en) 1990-02-28
ES469285A1 (en) 1979-09-16
IL51743A (en) 1980-10-26
DK161331B (en) 1991-06-24
GR61146B (en) 1978-09-27
NZ183687A (en) 1979-01-11
ES469287A1 (en) 1979-09-16
SE443143B (en) 1986-02-17
NO158505C (en) 1988-09-21
RO71742A (en) 1982-02-26
HU172720B (en) 1978-11-28
CY1158A (en) 1983-01-28
PT66346B (en) 1978-08-16
NO158505B (en) 1988-06-13
YU44039B (en) 1990-02-28
DE2713370C2 (en) 1994-04-21
DD129792A5 (en) 1978-02-08
YU173783A (en) 1983-12-31
ES457174A1 (en) 1978-08-16
AR224606A1 (en) 1981-12-30
NO862107L (en) 1977-09-27
DE2713370A1 (en) 1977-09-29
NO771023L (en) 1977-09-27
RO78228A (en) 1982-02-01
IE44794B1 (en) 1982-04-07
PT66346A (en) 1977-04-01
MX4348E (en) 1982-04-05
YU173883A (en) 1983-12-31
SE7703325L (en) 1977-09-26
DK161331C (en) 1991-12-09

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Legal Events

Date Code Title Description
MM4A Patent lapsed