ES469016A1 - Un procedimiento para la preparacion de alfa1 timosina - Google Patents
Un procedimiento para la preparacion de alfa1 timosinaInfo
- Publication number
- ES469016A1 ES469016A1 ES469016A ES469016A ES469016A1 ES 469016 A1 ES469016 A1 ES 469016A1 ES 469016 A ES469016 A ES 469016A ES 469016 A ES469016 A ES 469016A ES 469016 A1 ES469016 A1 ES 469016A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- glu
- formation
- preparation
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229960004231 thymalfasin Drugs 0.000 abstract 2
- 108010078233 Thymalfasin Proteins 0.000 abstract 1
- 102400000800 Thymosin alpha-1 Human genes 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78989877A | 1977-04-22 | 1977-04-22 | |
| US05/871,563 US4116951A (en) | 1977-04-22 | 1978-01-23 | [Asn2 ]-thymosin α1 and analogs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469016A1 true ES469016A1 (es) | 1980-01-01 |
Family
ID=27120967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469016A Expired ES469016A1 (es) | 1977-04-22 | 1978-04-21 | Un procedimiento para la preparacion de alfa1 timosina |
Country Status (18)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| EP0033384B1 (de) * | 1980-01-18 | 1984-02-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunstimulierender Wirkung, und Thymosin-alpha-1-Fragmente |
| US4339427A (en) * | 1980-04-14 | 1982-07-13 | Hoffmann-La Roche Inc. | Radioimmunoassay of thymosinα |
| EP0056594B1 (de) * | 1981-01-14 | 1984-09-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunregulierender Wirkung und Thymosin-alpha-1-Fragmente |
| CN1058500C (zh) * | 1993-02-03 | 2000-11-15 | 施塞克龙药品公司 | 胸腺素α－1衍生物 |
| US6262230B1 (en) * | 1994-01-28 | 2001-07-17 | Sciclone Pharmaceuticals Inc. | Analogs of thymosin α1 |
-
1978
- 1978-04-17 CH CH408878A patent/CH641152A5/de not_active IP Right Cessation
- 1978-04-18 DK DK169478A patent/DK147918C/da not_active IP Right Cessation
- 1978-04-19 DE DE19782817082 patent/DE2817082A1/de not_active Ceased
- 1978-04-20 GR GR56036A patent/GR71886B/el unknown
- 1978-04-20 FR FR7811686A patent/FR2401134A1/fr active Granted
- 1978-04-21 FI FI781241A patent/FI781241A7/fi not_active Application Discontinuation
- 1978-04-21 SE SE7804612A patent/SE447262B/sv not_active IP Right Cessation
- 1978-04-21 NO NO781404A patent/NO781404L/no unknown
- 1978-04-21 GB GB1574/78A patent/GB1590668A/en not_active Expired
- 1978-04-21 LU LU79488A patent/LU79488A1/de unknown
- 1978-04-21 HU HU78HO2067A patent/HU180783B/hu unknown
- 1978-04-21 AT AT0286178A patent/AT364470B/de not_active IP Right Cessation
- 1978-04-21 CA CA301,643A patent/CA1113088A/en not_active Expired
- 1978-04-21 IT IT22629/78A patent/IT1113134B/it active
- 1978-04-21 PT PT67937A patent/PT67937B/pt unknown
- 1978-04-21 ES ES469016A patent/ES469016A1/es not_active Expired
- 1978-04-21 JP JP4673978A patent/JPS53137914A/ja active Pending
- 1978-04-24 NL NL7804364A patent/NL7804364A/xx not_active Application Discontinuation
- 1978-12-15 FR FR7835404A patent/FR2405926A1/fr active Granted
-
1982
- 1982-05-13 NO NO821608A patent/NO148924C/no unknown
- 1982-11-05 CH CH645082A patent/CH641153A5/de not_active IP Right Cessation
- 1982-11-05 CH CH644982A patent/CH640218A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH640218A5 (en) | 1983-12-30 |
| DK169478A (da) | 1978-10-23 |
| DE2817082A1 (de) | 1978-11-02 |
| ATA286178A (de) | 1981-03-15 |
| HU180783B (en) | 1983-04-29 |
| NO148924B (no) | 1983-10-03 |
| SE447262B (sv) | 1986-11-03 |
| AT364470B (de) | 1981-10-27 |
| IT1113134B (it) | 1986-01-20 |
| DK147918B (da) | 1985-01-07 |
| PT67937B (en) | 1980-04-07 |
| FR2405926A1 (fr) | 1979-05-11 |
| CA1113088A (en) | 1981-11-24 |
| GB1590668A (en) | 1981-06-03 |
| PT67937A (en) | 1978-05-01 |
| NO821608L (no) | 1978-10-24 |
| DK147918C (da) | 1985-08-19 |
| CH641153A5 (en) | 1984-02-15 |
| FI781241A7 (fi) | 1978-10-23 |
| NL7804364A (nl) | 1978-10-24 |
| NO148924C (no) | 1984-01-11 |
| CH641152A5 (en) | 1984-02-15 |
| FR2405926B1 (enrdf_load_stackoverflow) | 1983-09-09 |
| LU79488A1 (de) | 1979-05-25 |
| SE7804612L (sv) | 1978-12-20 |
| FR2401134B1 (enrdf_load_stackoverflow) | 1983-09-30 |
| FR2401134A1 (fr) | 1979-03-23 |
| IT7822629A0 (it) | 1978-04-21 |
| GR71886B (enrdf_load_stackoverflow) | 1983-08-04 |
| JPS53137914A (en) | 1978-12-01 |
| NO781404L (no) | 1978-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |