ES459256A1 - Un metodo de preparacion de 3-(3-carboxi-4-hidroxifenil)-4,5-dihidro-2-fenilbenz(e)indol. - Google Patents
Un metodo de preparacion de 3-(3-carboxi-4-hidroxifenil)-4,5-dihidro-2-fenilbenz(e)indol.Info
- Publication number
- ES459256A1 ES459256A1 ES459256A ES459256A ES459256A1 ES 459256 A1 ES459256 A1 ES 459256A1 ES 459256 A ES459256 A ES 459256A ES 459256 A ES459256 A ES 459256A ES 459256 A1 ES459256 A1 ES 459256A1
- Authority
- ES
- Spain
- Prior art keywords
- phenylbenz
- indole
- hydroxyphenyl
- dihydro
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- HAWWPSYXSLJRBO-UHFFFAOYSA-N fendosal Chemical compound C1=C(O)C(C(=O)O)=CC(N2C(=CC=3C4=CC=CC=C4CCC=32)C=2C=CC=CC=2)=C1 HAWWPSYXSLJRBO-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000001613 neoplastic effect Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010061309 Neoplasm progression Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000005751 tumor progression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/692,331 US4066659A (en) | 1976-06-03 | 1976-06-03 | Method of preparation of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole and valuable intermediates related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459256A1 true ES459256A1 (es) | 1978-03-01 |
Family
ID=24780138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES459256A Expired ES459256A1 (es) | 1976-06-03 | 1977-05-28 | Un metodo de preparacion de 3-(3-carboxi-4-hidroxifenil)-4,5-dihidro-2-fenilbenz(e)indol. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4066659A (en, 2012) |
| JP (1) | JPS5325556A (en, 2012) |
| AT (1) | AT353786B (en, 2012) |
| BE (1) | BE855406A (en, 2012) |
| CA (1) | CA1105936A (en, 2012) |
| CH (1) | CH629774A5 (en, 2012) |
| DE (1) | DE2724601A1 (en, 2012) |
| DK (1) | DK145296C (en, 2012) |
| ES (1) | ES459256A1 (en, 2012) |
| FI (1) | FI65059C (en, 2012) |
| HU (1) | HU176801B (en, 2012) |
| IT (1) | IT1076781B (en, 2012) |
| NL (1) | NL7705807A (en, 2012) |
| SE (1) | SE425391B (en, 2012) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1356431A (en) * | 1971-06-03 | 1974-06-12 | Wyeth John & Brother Ltd | Substituted benz-g-indoles |
| US3931407A (en) * | 1973-03-01 | 1976-01-06 | American Hoechst Corporation | Method of treatment with and compositions containing condensed pyrroles bearing an N-phenyl substituent |
-
1976
- 1976-06-03 US US05/692,331 patent/US4066659A/en not_active Expired - Lifetime
-
1977
- 1977-05-26 NL NL7705807A patent/NL7705807A/xx not_active Application Discontinuation
- 1977-05-28 ES ES459256A patent/ES459256A1/es not_active Expired
- 1977-05-31 CH CH664677A patent/CH629774A5/de not_active IP Right Cessation
- 1977-06-01 IT IT24269/77A patent/IT1076781B/it active
- 1977-06-01 FI FI771747A patent/FI65059C/fi not_active IP Right Cessation
- 1977-06-01 DE DE19772724601 patent/DE2724601A1/de active Granted
- 1977-06-02 DK DK243677A patent/DK145296C/da active
- 1977-06-02 HU HU77HO1992A patent/HU176801B/hu not_active IP Right Cessation
- 1977-06-02 AT AT392877A patent/AT353786B/de not_active IP Right Cessation
- 1977-06-02 CA CA279,689A patent/CA1105936A/en not_active Expired
- 1977-06-03 SE SE7706526A patent/SE425391B/xx not_active IP Right Cessation
- 1977-06-03 BE BE178212A patent/BE855406A/xx not_active IP Right Cessation
- 1977-06-03 JP JP6568277A patent/JPS5325556A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AT353786B (de) | 1979-12-10 |
| DE2724601C2 (en, 2012) | 1988-03-03 |
| DK243677A (da) | 1977-12-04 |
| HU176801B (en) | 1981-05-28 |
| FI771747A7 (en, 2012) | 1977-12-04 |
| DK145296B (da) | 1982-10-25 |
| BE855406A (fr) | 1977-12-05 |
| ATA392877A (de) | 1979-05-15 |
| FI65059B (fi) | 1983-11-30 |
| FI65059C (fi) | 1984-03-12 |
| CH629774A5 (de) | 1982-05-14 |
| DK145296C (da) | 1983-03-14 |
| DE2724601A1 (de) | 1977-12-22 |
| SE425391B (sv) | 1982-09-27 |
| US4066659A (en) | 1978-01-03 |
| CA1105936A (en) | 1981-07-28 |
| NL7705807A (nl) | 1977-12-06 |
| SE7706526L (sv) | 1977-12-04 |
| IT1076781B (it) | 1985-04-27 |
| JPS5325556A (en) | 1978-03-09 |
| JPS6120546B2 (en, 2012) | 1986-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |