BE855406A - Procede de preparation de 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole et produits obtenus, ainsi que les intermediaires - Google Patents

Procede de preparation de 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole et produits obtenus, ainsi que les intermediaires

Info

Publication number
BE855406A
BE855406A BE178212A BE178212A BE855406A BE 855406 A BE855406 A BE 855406A BE 178212 A BE178212 A BE 178212A BE 178212 A BE178212 A BE 178212A BE 855406 A BE855406 A BE 855406A
Authority
BE
Belgium
Prior art keywords
phenylbenz
intermediaries
indole
hydroxyphenyl
dihydro
Prior art date
Application number
BE178212A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BE855406A publication Critical patent/BE855406A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BE178212A 1976-06-03 1977-06-03 Procede de preparation de 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole et produits obtenus, ainsi que les intermediaires BE855406A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/692,331 US4066659A (en) 1976-06-03 1976-06-03 Method of preparation of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole and valuable intermediates related thereto

Publications (1)

Publication Number Publication Date
BE855406A true BE855406A (fr) 1977-12-05

Family

ID=24780138

Family Applications (1)

Application Number Title Priority Date Filing Date
BE178212A BE855406A (fr) 1976-06-03 1977-06-03 Procede de preparation de 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz (e) indole et produits obtenus, ainsi que les intermediaires

Country Status (14)

Country Link
US (1) US4066659A (fr)
JP (1) JPS5325556A (fr)
AT (1) AT353786B (fr)
BE (1) BE855406A (fr)
CA (1) CA1105936A (fr)
CH (1) CH629774A5 (fr)
DE (1) DE2724601A1 (fr)
DK (1) DK145296C (fr)
ES (1) ES459256A1 (fr)
FI (1) FI65059C (fr)
HU (1) HU176801B (fr)
IT (1) IT1076781B (fr)
NL (1) NL7705807A (fr)
SE (1) SE425391B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356431A (en) * 1971-06-03 1974-06-12 Wyeth John & Brother Ltd Substituted benz-g-indoles
US3931407A (en) * 1973-03-01 1976-01-06 American Hoechst Corporation Method of treatment with and compositions containing condensed pyrroles bearing an N-phenyl substituent

Also Published As

Publication number Publication date
DK145296C (da) 1983-03-14
ATA392877A (de) 1979-05-15
HU176801B (en) 1981-05-28
FI771747A (fr) 1977-12-04
CH629774A5 (de) 1982-05-14
CA1105936A (fr) 1981-07-28
SE7706526L (sv) 1977-12-04
AT353786B (de) 1979-12-10
NL7705807A (nl) 1977-12-06
DK145296B (da) 1982-10-25
DE2724601A1 (de) 1977-12-22
FI65059B (fi) 1983-11-30
JPS5325556A (en) 1978-03-09
US4066659A (en) 1978-01-03
IT1076781B (it) 1985-04-27
SE425391B (sv) 1982-09-27
ES459256A1 (es) 1978-03-01
DK243677A (da) 1977-12-04
FI65059C (fi) 1984-03-12
DE2724601C2 (fr) 1988-03-03
JPS6120546B2 (fr) 1986-05-22

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: HOECHST A.G.

Effective date: 19900630