ES456999A1 - Cyclopentanol lactones - Google Patents

Cyclopentanol lactones

Info

Publication number
ES456999A1
ES456999A1 ES456999A ES456999A ES456999A1 ES 456999 A1 ES456999 A1 ES 456999A1 ES 456999 A ES456999 A ES 456999A ES 456999 A ES456999 A ES 456999A ES 456999 A1 ES456999 A1 ES 456999A1
Authority
ES
Spain
Prior art keywords
group
those
compounds
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES456999A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES456999A1 publication Critical patent/ES456999A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Abstract

The compounds of formula: < IMAGE > are prepared from corresponding carboxylic acids of formula: < IMAGE > by a reaction capable of converting the carboxyl group to a functional derivative. The meaning of the symbols is given in Claim 1. Of the compounds obtained, those which have a 15-tetrahydropyranyloxy group can be hydrolysed, those which have a hydroxyl group can be esterified, and those which have a secondary alcohol group in position 15 can be oxidised to the corresponding ketone or dehydrated in position 15, 16 finally, the double bond in position 13, 14 and the triple bond of an alkynyl group in position 15 can be hydrogenated. The compounds display a hypotensive activity they can be employed in the treatment of hypertension (high blood pressure) and of circulatory disorders.
ES456999A 1976-03-19 1977-03-18 Cyclopentanol lactones Expired ES456999A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7608004A FR2344285A1 (en) 1976-03-19 1976-03-19 NEW LACTONS DERIVED FROM CYCLOPENTANOL, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ES456999A1 true ES456999A1 (en) 1978-01-16

Family

ID=9170682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES456999A Expired ES456999A1 (en) 1976-03-19 1977-03-18 Cyclopentanol lactones

Country Status (20)

Country Link
JP (1) JPS52113956A (en)
AT (1) AT357275B (en)
AU (1) AU506760B2 (en)
BE (1) BE852624A (en)
CA (1) CA1094569A (en)
CH (1) CH620688A5 (en)
DE (1) DE2711950A1 (en)
DK (1) DK119377A (en)
ES (1) ES456999A1 (en)
FR (1) FR2344285A1 (en)
GB (1) GB1538717A (en)
HU (1) HU178332B (en)
IE (1) IE45124B1 (en)
IL (1) IL51690A (en)
LU (1) LU76976A1 (en)
NL (1) NL7703056A (en)
PT (1) PT66326B (en)
SE (1) SE436877B (en)
SU (2) SU749364A3 (en)
ZA (1) ZA771654B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439779A2 (en) * 1976-03-19 1980-05-23 Roussel Uclaf Hypotensive hydroxy cyclopentane carboxylic acid lactone(s)
FR2443466A1 (en) * 1978-12-05 1980-07-04 Roussel Uclaf NOVEL B-LACTONS DERIVED FROM 2-HYDROXY CYCLOPENTANE CARBOXYLIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
DE3722133A1 (en) * 1987-07-04 1989-01-12 Bayer Ag AZOLYL TETRAHYDROPYRAN DERIVATIVES
EP1142886A1 (en) * 2000-04-07 2001-10-10 Aventis Pharma Deutschland GmbH Percyquinnin, a process for its production and its use as a pharmaceutical
CN100417650C (en) * 2006-08-17 2008-09-10 中国科学院昆明植物研究所 Vibralactone, preparation method and medicinal application thereof
DK2653468T3 (en) * 2009-07-28 2016-06-06 Ono Pharmaceutical Co Bicyclic compound AND USE THEREOF FOR MEDICAL PURPOSES

Also Published As

Publication number Publication date
FR2344285A1 (en) 1977-10-14
BE852624A (en) 1977-09-19
SE436877B (en) 1985-01-28
DK119377A (en) 1977-09-20
IE45124B1 (en) 1982-06-30
ZA771654B (en) 1978-04-26
LU76976A1 (en) 1977-10-03
DE2711950A1 (en) 1977-09-29
NL7703056A (en) 1977-09-21
JPS52113956A (en) 1977-09-24
IL51690A0 (en) 1977-05-31
CH620688A5 (en) 1980-12-15
AU506760B2 (en) 1980-01-24
CA1094569A (en) 1981-01-27
AT357275B (en) 1980-06-25
SE7702908L (en) 1977-09-20
IL51690A (en) 1982-02-28
SU745366A3 (en) 1980-06-30
HU178332B (en) 1982-04-28
AU2346677A (en) 1978-09-28
SU749364A3 (en) 1980-07-15
ATA195077A (en) 1979-11-15
GB1538717A (en) 1979-01-24
PT66326B (en) 1979-01-18
PT66326A (en) 1977-04-01
FR2344285B1 (en) 1979-02-02
IE45124L (en) 1977-09-19
JPS62146B2 (en) 1987-01-06

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