ES455489A1 - 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them - Google Patents
1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing themInfo
- Publication number
- ES455489A1 ES455489A1 ES455489A ES455489A ES455489A1 ES 455489 A1 ES455489 A1 ES 455489A1 ES 455489 A ES455489 A ES 455489A ES 455489 A ES455489 A ES 455489A ES 455489 A1 ES455489 A1 ES 455489A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- aralkoxyphenyl
- arylalkylamino
- bis
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Compounds of the formula I which lower blood pressure and reduce the heart rate < IMAGE > are prepared, in which each of the symbols Ar1, Ar2 and Ar3 denotes a phenyl radical which is unsubstituted or substituted by one or more lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino, mono-lower-alkylamino or di-lower-alkylamino, aminomethyl, mono-lower-alkylaminomethyl or di-lower-alkylaminomethyl groups or one or more halogen atoms, Ph is a phenylene radical which can optionally be substituted by one of the substituents mentioned for Ar1 and n is a number from 0 to 4, and each of the symbols m and p represents a number from 1 to 4, r is the number 1 or 2, and R1 is hydrogen or hydroxyl, and salts of these compounds. These are obtained by reduction of a compound which contains the group of the formula -CO-Cp-1H2p-2- in place of the group -CpH2pin the formula.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49494874A | 1974-08-05 | 1974-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455489A1 true ES455489A1 (en) | 1978-01-01 |
Family
ID=23966620
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439997A Expired ES439997A1 (en) | 1974-08-05 | 1975-08-04 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455491A Expired ES455491A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455488A Expired ES455488A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455490A Expired ES455490A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455489A Expired ES455489A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439997A Expired ES439997A1 (en) | 1974-08-05 | 1975-08-04 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455491A Expired ES455491A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455488A Expired ES455488A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
| ES455490A Expired ES455490A1 (en) | 1974-08-05 | 1977-01-31 | 1- (aralkoxyphenyl) - 2- or -3 - (bis - arylalkylamino)-alkanes process for their manufacture and pharmaceutical preparations containing them |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5141345A (en) |
| AT (1) | AT340388B (en) |
| BE (1) | BE832082A (en) |
| CA (1) | CA1069923A (en) |
| CH (5) | CH612910A5 (en) |
| DE (1) | DE2534339A1 (en) |
| DK (1) | DK317175A (en) |
| ES (5) | ES439997A1 (en) |
| FI (1) | FI752095A (en) |
| FR (1) | FR2281105A1 (en) |
| GB (1) | GB1504604A (en) |
| HU (1) | HU175581B (en) |
| IE (1) | IE42335B1 (en) |
| IL (1) | IL47813A (en) |
| NL (1) | NL7509270A (en) |
| NO (1) | NO752621L (en) |
| SE (1) | SE7508181L (en) |
| ZA (2) | ZA754192B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5726653A (en) * | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| WO2005090286A1 (en) * | 2004-03-12 | 2005-09-29 | Eli Lilly And Company | Opioid receptor antagonists |
-
1975
- 1975-07-01 ZA ZA00754192A patent/ZA754192B/en unknown
- 1975-07-11 DK DK317175A patent/DK317175A/en unknown
- 1975-07-17 SE SE7508181A patent/SE7508181L/en unknown
- 1975-07-21 FI FI752095A patent/FI752095A/fi not_active Application Discontinuation
- 1975-07-23 NO NO752621A patent/NO752621L/no unknown
- 1975-07-25 IL IL47813A patent/IL47813A/en unknown
- 1975-07-30 CH CH25279A patent/CH612910A5/en not_active IP Right Cessation
- 1975-07-30 CH CH25479A patent/CH612912A5/en not_active IP Right Cessation
- 1975-07-30 CH CH993575A patent/CH612909A5/en not_active IP Right Cessation
- 1975-07-30 CH CH25379A patent/CH612911A5/en not_active IP Right Cessation
- 1975-07-30 GB GB31893/75A patent/GB1504604A/en not_active Expired
- 1975-07-30 CH CH25579A patent/CH612913A5/en not_active IP Right Cessation
- 1975-08-01 DE DE19752534339 patent/DE2534339A1/en not_active Withdrawn
- 1975-08-01 CA CA232,735A patent/CA1069923A/en not_active Expired
- 1975-08-01 HU HU75CI1597A patent/HU175581B/en unknown
- 1975-08-01 FR FR7524088A patent/FR2281105A1/en active Granted
- 1975-08-01 IE IE1724/75A patent/IE42335B1/en unknown
- 1975-08-04 BE BE158907A patent/BE832082A/en unknown
- 1975-08-04 AT AT604275A patent/AT340388B/en not_active IP Right Cessation
- 1975-08-04 NL NL7509270A patent/NL7509270A/en not_active Application Discontinuation
- 1975-08-04 ZA ZA00755018A patent/ZA755018B/en unknown
- 1975-08-04 ES ES439997A patent/ES439997A1/en not_active Expired
- 1975-08-05 JP JP50094800A patent/JPS5141345A/en active Pending
-
1977
- 1977-01-31 ES ES455491A patent/ES455491A1/en not_active Expired
- 1977-01-31 ES ES455488A patent/ES455488A1/en not_active Expired
- 1977-01-31 ES ES455490A patent/ES455490A1/en not_active Expired
- 1977-01-31 ES ES455489A patent/ES455489A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7509270A (en) | 1976-02-09 |
| AU8362675A (en) | 1977-02-10 |
| ES439997A1 (en) | 1977-06-16 |
| ZA755018B (en) | 1976-07-28 |
| ZA754192B (en) | 1976-06-30 |
| SE7508181L (en) | 1976-02-06 |
| CH612911A5 (en) | 1979-08-31 |
| CA1069923A (en) | 1980-01-15 |
| IL47813A (en) | 1979-07-25 |
| FR2281105B1 (en) | 1980-02-08 |
| GB1504604A (en) | 1978-03-22 |
| FI752095A (en) | 1976-02-06 |
| CH612910A5 (en) | 1979-08-31 |
| IE42335B1 (en) | 1980-07-16 |
| NO752621L (en) | 1976-02-06 |
| ES455490A1 (en) | 1978-01-01 |
| FR2281105A1 (en) | 1976-03-05 |
| AT340388B (en) | 1977-12-12 |
| CH612912A5 (en) | 1979-08-31 |
| JPS5141345A (en) | 1976-04-07 |
| BE832082A (en) | 1976-02-04 |
| ES455491A1 (en) | 1978-01-01 |
| DE2534339A1 (en) | 1976-02-19 |
| ES455488A1 (en) | 1978-01-01 |
| HU175581B (en) | 1980-09-28 |
| CH612913A5 (en) | 1979-08-31 |
| DK317175A (en) | 1976-02-06 |
| ATA604275A (en) | 1977-04-15 |
| IL47813A0 (en) | 1975-10-15 |
| IE42335L (en) | 1976-02-05 |
| CH612909A5 (en) | 1979-08-31 |
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