ES416816A1 - A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES416816A1 ES416816A1 ES416816A ES416816A ES416816A1 ES 416816 A1 ES416816 A1 ES 416816A1 ES 416816 A ES416816 A ES 416816A ES 416816 A ES416816 A ES 416816A ES 416816 A1 ES416816 A1 ES 416816A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- general formula
- indicated above
- meaning indicated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
A procedure for the preparation of triazolobenzodiazepines of the general formula **(See formula)** in which D represents pyridyl, phenyl or phenyl mono or di-substituted by trifluoromethyl or halogen, n represents the integer 0 or 1, R1 and R2 each represent hydrogen, halogen, nitro or trifluoromethyl, R represents hydrogen or lower alkyl or, when n represents O, R3 can also represent lower alkanzyloxy or hydroxyl, and R10 represents hydrogen, lower alkyl or hydroxy-lower alkyl, and its pharmaceutically acceptable acid addition salts, characterized in that it comprises treating a compound of the general formula **(See formula)** in which D, a, R1 and R2 have the meaning indicated above, R'3 represents hydrogen or lower alkyl and R7 represents lower alkyl, with a compound of the general formula R11 - NH - NH2 III in which R11 represents hydrogen or R10CO- where R10 has the meaning indicated above, and if a compound of the general formula is obtained **(See formula)** where D, n, R1, R2, R3 and R11 have the meaning indicated above, turn it into a compound of the general formula **(See formula)** in which D, n, R1, R2, R'3 and R10 have the meaning indicated above; and treating, if desired, a compound of the general formula la, where n is 1 and R'3 represents hydrogen, with an agent providing the lower alkylene group to obtain a compound of the general formula **(See formula)** in which D, R1, R2 and R10 have the meaning indicated above and R'3 represents lower alkanoyloxy, and hydrolyze this, if desired, to obtain a compound of the general formula **(See formula)** in which D, R1, R2 and R10 have the meaning indicated above, or, if n in formula II is 1 and it is desired, to prepare a compound of the formula where n is 0, remove oxygen from the nitrone group of a compound of formula II, IV or where n is 1, and if desired, converting a compound of formula I to a respective pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US271434A US3879406A (en) | 1972-07-13 | 1972-07-13 | Preparation of triazolobenzodiazepines |
ZA734256A ZA734256B (en) | 1972-07-13 | 1973-06-22 | Process for the preparation of benzodiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES416816A1 true ES416816A1 (en) | 1976-02-16 |
Family
ID=26954893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES416816A Expired ES416816A1 (en) | 1972-07-13 | 1973-07-12 | A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES416816A1 (en) |
-
1973
- 1973-07-12 ES ES416816A patent/ES416816A1/en not_active Expired
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