ES416816A1 - A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES416816A1
ES416816A1 ES416816A ES416816A ES416816A1 ES 416816 A1 ES416816 A1 ES 416816A1 ES 416816 A ES416816 A ES 416816A ES 416816 A ES416816 A ES 416816A ES 416816 A1 ES416816 A1 ES 416816A1
Authority
ES
Spain
Prior art keywords
compound
formula
general formula
indicated above
meaning indicated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES416816A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US271434A external-priority patent/US3879406A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES416816A1 publication Critical patent/ES416816A1/en
Expired legal-status Critical Current

Links

Abstract

A procedure for the preparation of triazolobenzodiazepines of the general formula **(See formula)** in which D represents pyridyl, phenyl or phenyl mono or di-substituted by trifluoromethyl or halogen, n represents the integer 0 or 1, R1 and R2 each represent hydrogen, halogen, nitro or trifluoromethyl, R represents hydrogen or lower alkyl or, when n represents O, R3 can also represent lower alkanzyloxy or hydroxyl, and R10 represents hydrogen, lower alkyl or hydroxy-lower alkyl, and its pharmaceutically acceptable acid addition salts, characterized in that it comprises treating a compound of the general formula **(See formula)** in which D, a, R1 and R2 have the meaning indicated above, R'3 represents hydrogen or lower alkyl and R7 represents lower alkyl, with a compound of the general formula R11 - NH - NH2 III in which R11 represents hydrogen or R10CO- where R10 has the meaning indicated above, and if a compound of the general formula is obtained **(See formula)** where D, n, R1, R2, R3 and R11 have the meaning indicated above, turn it into a compound of the general formula **(See formula)** in which D, n, R1, R2, R'3 and R10 have the meaning indicated above; and treating, if desired, a compound of the general formula la, where n is 1 and R'3 represents hydrogen, with an agent providing the lower alkylene group to obtain a compound of the general formula **(See formula)** in which D, R1, R2 and R10 have the meaning indicated above and R'3 represents lower alkanoyloxy, and hydrolyze this, if desired, to obtain a compound of the general formula **(See formula)** in which D, R1, R2 and R10 have the meaning indicated above, or, if n in formula II is 1 and it is desired, to prepare a compound of the formula where n is 0, remove oxygen from the nitrone group of a compound of formula II, IV or where n is 1, and if desired, converting a compound of formula I to a respective pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES416816A 1972-07-13 1973-07-12 A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding) Expired ES416816A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US271434A US3879406A (en) 1972-07-13 1972-07-13 Preparation of triazolobenzodiazepines
ZA734256A ZA734256B (en) 1972-07-13 1973-06-22 Process for the preparation of benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
ES416816A1 true ES416816A1 (en) 1976-02-16

Family

ID=26954893

Family Applications (1)

Application Number Title Priority Date Filing Date
ES416816A Expired ES416816A1 (en) 1972-07-13 1973-07-12 A procedure for the preparation of triazolobenzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES416816A1 (en)

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