ES425626A1 - Acylxylidide local anaesthetics - Google Patents
Acylxylidide local anaestheticsInfo
- Publication number
- ES425626A1 ES425626A1 ES425626A ES425626A ES425626A1 ES 425626 A1 ES425626 A1 ES 425626A1 ES 425626 A ES425626 A ES 425626A ES 425626 A ES425626 A ES 425626A ES 425626 A1 ES425626 A1 ES 425626A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- reacted
- propyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A procedure for preparing acyl-xylidide compounds of the structural formula ** (See formula) ** in optically active or racemic form, in which formula R1 is ethyl, propyl or butyl; R2 and R3 are each selected from the group consisting of methyl, ethyl, propyl, and butyl; R2 together with R3 is tetramethylene; the total sum of carbon atoms in R1, R2 and R3 is at least six; and its pharmaceutically acceptable salts; characterized in that a compound of the formula is reacted ** (See formula) ** wherein R1 and Y have the meaning set forth above, with a compound of the formula H2 - N - R2 wherein R2 has the meaning set forth above, for the formation of a compound of formula ** (See formula) ** after which this compound is reacted with an alcoholizing agent to form a compound of formula I, and the compound of formula I thus formed is reacted, if desired, with a pharmaceutically acceptable acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10077770A | 1970-12-22 | 1970-12-22 | |
| US00164022A US3812147A (en) | 1970-12-22 | 1971-07-19 | Acylxylidide local anaesthetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES425626A1 true ES425626A1 (en) | 1976-06-16 |
Family
ID=26797539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398210A Expired ES398210A1 (en) | 1970-12-22 | 1971-12-21 | Acylxylidide local anaesthetics |
| ES425626A Expired ES425626A1 (en) | 1970-12-22 | 1974-04-24 | Acylxylidide local anaesthetics |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398210A Expired ES398210A1 (en) | 1970-12-22 | 1971-12-21 | Acylxylidide local anaesthetics |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US3812147A (en) |
| JP (1) | JPS5644063B1 (en) |
| AR (1) | AR193840A1 (en) |
| AT (1) | AT319205B (en) |
| AU (1) | AU468489B2 (en) |
| BE (1) | BE776656A (en) |
| BR (1) | BR7108466D0 (en) |
| CA (1) | CA943966A (en) |
| DD (1) | DD99779A5 (en) |
| DE (1) | DE2162744C3 (en) |
| DK (1) | DK139814B (en) |
| ES (2) | ES398210A1 (en) |
| FI (1) | FI55027C (en) |
| FR (1) | FR2118985B1 (en) |
| GB (1) | GB1369259A (en) |
| HU (1) | HU163373B (en) |
| IE (1) | IE35909B1 (en) |
| IT (1) | IT1066334B (en) |
| NL (2) | NL172149C (en) |
| NO (1) | NO135934C (en) |
| PL (1) | PL83097B1 (en) |
| SE (1) | SE393374B (en) |
| SU (1) | SU419023A3 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237068A (en) * | 1971-07-28 | 1980-12-02 | Astra Pharmaceutical Products, Inc. | Primary aminoacylanilides |
| US3957996A (en) * | 1971-12-08 | 1976-05-18 | Astra Pharmaceutical Products, Inc. | Pharmaceutical local anesthetic compositions |
| US3966934A (en) * | 1971-12-08 | 1976-06-29 | Astra Pharmaceutical Products, Inc. | Synergistic local anesthetic compositions |
| US3975443A (en) * | 1972-06-06 | 1976-08-17 | Allen & Hanburys Limited | 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine |
| JPS598269B2 (en) * | 1975-08-22 | 1984-02-23 | 萬有製薬株式会社 | Omega - aminoalkanesane arylamide |
| EP0062322A1 (en) * | 1981-04-03 | 1982-10-13 | The B.F. GOODRICH Company | Improved process for synthesis of hindered amine stabilizers for polymeric materials |
| US4891058A (en) * | 1988-07-18 | 1990-01-02 | Ici Americas Inc. | 1-alkyl-3-aryl imidazolidine-2,4-diones and herbicidal use |
| SE8900685D0 (en) * | 1989-02-28 | 1989-02-28 | Astra Ab | NEW COMPOUNDS |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| KR20090082507A (en) | 2006-11-20 | 2009-07-30 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Methods, compositions, and kits for treating pain and pruritis |
| CA3027255C (en) | 2009-07-10 | 2022-06-21 | The General Hospital Corporation | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| JP6833811B2 (en) | 2015-08-03 | 2021-02-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Charged ion channel blockers and how to use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CA3129089A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Ester substituted ion channel blockers and methods for use |
| CA3129117A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Charged ion channel blockers and methods for use |
| US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP3937945A4 (en) | 2019-03-11 | 2023-01-04 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP4054586A4 (en) | 2019-11-06 | 2023-11-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CA3155586A1 (en) | 2019-11-06 | 2021-05-14 | Bridget M. Cole | Charged ion channel blockers and methods for use |
| CN115279731B (en) | 2020-03-11 | 2024-09-13 | 诺西恩医疗公司 | Charged ion channel blockers and methods of use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1124837A (en) * | 1966-06-03 | 1968-08-21 | Wyeth John & Brother Ltd | Substituted anilides |
-
1971
- 1971-07-19 US US00164022A patent/US3812147A/en not_active Expired - Lifetime
- 1971-12-07 SE SE7115656A patent/SE393374B/en unknown
- 1971-12-14 BE BE776656A patent/BE776656A/en not_active IP Right Cessation
- 1971-12-15 SU SU1726195A patent/SU419023A3/en active
- 1971-12-16 HU HUAA690A patent/HU163373B/hu unknown
- 1971-12-17 DK DK619771AA patent/DK139814B/en not_active IP Right Cessation
- 1971-12-17 DE DE2162744A patent/DE2162744C3/en not_active Expired
- 1971-12-17 NO NO4669/71A patent/NO135934C/no unknown
- 1971-12-18 IT IT54845/71A patent/IT1066334B/en active
- 1971-12-20 AT AT1089671A patent/AT319205B/en not_active IP Right Cessation
- 1971-12-20 IE IE1609/71A patent/IE35909B1/en unknown
- 1971-12-20 AU AU37099/71A patent/AU468489B2/en not_active Expired
- 1971-12-21 PL PL1971152331A patent/PL83097B1/pl unknown
- 1971-12-21 ES ES398210A patent/ES398210A1/en not_active Expired
- 1971-12-21 BR BR8466/71A patent/BR7108466D0/en unknown
- 1971-12-21 GB GB5937771A patent/GB1369259A/en not_active Expired
- 1971-12-21 DD DD159785A patent/DD99779A5/xx unknown
- 1971-12-21 AR AR239721A patent/AR193840A1/en active
- 1971-12-21 FR FR7145983A patent/FR2118985B1/fr not_active Expired
- 1971-12-21 CA CA130,662A patent/CA943966A/en not_active Expired
- 1971-12-22 NL NLAANVRAGE7117644,A patent/NL172149C/en not_active IP Right Cessation
- 1971-12-22 FI FI3658/71A patent/FI55027C/en active
- 1971-12-22 JP JP10453571A patent/JPS5644063B1/ja active Pending
-
1974
- 1974-04-24 ES ES425626A patent/ES425626A1/en not_active Expired
-
1982
- 1982-10-26 NL NL8204126A patent/NL8204126A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2162744A1 (en) | 1972-07-06 |
| AT319205B (en) | 1974-12-10 |
| FI55027C (en) | 1979-05-10 |
| NL172149C (en) | 1983-07-18 |
| ES398210A1 (en) | 1975-03-16 |
| DE2162744B2 (en) | 1981-07-02 |
| FI55027B (en) | 1979-01-31 |
| FR2118985A1 (en) | 1972-08-04 |
| BR7108466D0 (en) | 1973-06-14 |
| BE776656A (en) | 1972-06-14 |
| JPS5644063B1 (en) | 1981-10-16 |
| NO135934C (en) | 1977-06-29 |
| DK139814C (en) | 1979-10-01 |
| CA943966A (en) | 1974-03-19 |
| US3812147A (en) | 1974-05-21 |
| NL172149B (en) | 1983-02-16 |
| AU3709971A (en) | 1973-06-28 |
| IE35909B1 (en) | 1976-06-23 |
| SE393374B (en) | 1977-05-09 |
| NL7117644A (en) | 1972-06-26 |
| AU468489B2 (en) | 1976-01-15 |
| SU419023A3 (en) | 1974-03-05 |
| PL83097B1 (en) | 1975-12-31 |
| NL8204126A (en) | 1983-02-01 |
| NO135934B (en) | 1977-03-21 |
| AR193840A1 (en) | 1973-05-31 |
| IT1066334B (en) | 1985-03-04 |
| HU163373B (en) | 1973-08-28 |
| GB1369259A (en) | 1974-10-23 |
| IE35909L (en) | 1972-06-22 |
| DE2162744C3 (en) | 1982-04-15 |
| DK139814B (en) | 1979-04-23 |
| FR2118985B1 (en) | 1975-12-26 |
| DD99779A5 (en) | 1973-08-20 |
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