ES455486A1 - Procedimiento para la obtencion de acidos fluorados. - Google Patents

Procedimiento para la obtencion de acidos fluorados.

Info

Publication number
ES455486A1
ES455486A1 ES455486A ES455486A ES455486A1 ES 455486 A1 ES455486 A1 ES 455486A1 ES 455486 A ES455486 A ES 455486A ES 455486 A ES455486 A ES 455486A ES 455486 A1 ES455486 A1 ES 455486A1
Authority
ES
Spain
Prior art keywords
radical
procedure
obtaining
acids
fluorated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455486A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES455486A1 publication Critical patent/ES455486A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/72—Polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para la obtención de ácidos fluorados, de fórmula: **(Fórmula)** en la que Ar es un radical fenilo que puede portar opcionalmente como sustituyente un radical 4-cloro, 4-flúor, 4-fenil, o 4-(p-cloro)fenilo, o Ar es un radical naft-1-ilo o naft-2-ilo que puede portar opcionalmente un radical 4- o 6-cloro; R1 es un radical hidroxi; R2 es un radical metilo; y X es un radical metileno; o una sal de adición de base farmacéuticamente aceptable de éste.
ES455486A 1974-12-06 1977-01-31 Procedimiento para la obtencion de acidos fluorados. Expired ES455486A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52829/74A GB1499508A (en) 1974-12-06 1974-12-06 3,3,3-trifluoropropionic acid derivatives

Publications (1)

Publication Number Publication Date
ES455486A1 true ES455486A1 (es) 1978-01-16

Family

ID=10465488

Family Applications (3)

Application Number Title Priority Date Filing Date
ES443237A Expired ES443237A1 (es) 1974-12-06 1975-12-05 Procedimiento para la obtencion de compuestos fluorados.
ES455486A Expired ES455486A1 (es) 1974-12-06 1977-01-31 Procedimiento para la obtencion de acidos fluorados.
ES455487A Expired ES455487A1 (es) 1974-12-06 1977-01-31 Procedimiento para la obtencion de fluorados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES443237A Expired ES443237A1 (es) 1974-12-06 1975-12-05 Procedimiento para la obtencion de compuestos fluorados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES455487A Expired ES455487A1 (es) 1974-12-06 1977-01-31 Procedimiento para la obtencion de fluorados.

Country Status (25)

Country Link
US (1) US4055595A (es)
JP (1) JPS51125227A (es)
AR (1) AR213278A1 (es)
AT (1) AT347432B (es)
BE (1) BE836353A (es)
CA (1) CA1064498A (es)
CH (1) CH618414A5 (es)
CS (1) CS191948B2 (es)
DD (1) DD122963A5 (es)
DE (1) DE2554882A1 (es)
DK (1) DK546575A (es)
ES (3) ES443237A1 (es)
FI (1) FI753393A7 (es)
FR (1) FR2293196A1 (es)
GB (1) GB1499508A (es)
HU (1) HU170016B (es)
IE (1) IE42454B1 (es)
IL (1) IL48477A (es)
LU (1) LU73936A1 (es)
NL (1) NL7514070A (es)
NO (1) NO753837L (es)
PL (3) PL102241B1 (es)
SE (1) SE7513676L (es)
SU (1) SU764608A3 (es)
ZA (1) ZA757089B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU884568A3 (ru) * 1977-10-07 1981-11-23 Сьянс Юньон Э Ко.,Сосьете Франсэз Де Решерш Медикаль(Фирма) Способ получени (арилалкил) алкановых кислот
ATE1855T1 (de) 1978-09-08 1982-12-15 Imperial Chemical Industries Plc Antiarthritische hydroxyessigsaeurederivate, pharmazeutische zusammensetzungen daraus und verfahren zu ihrer herstellung.
FR2460286A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Agrochimie Procede de preparation d'acide phenoxy-2 propioniques optiquement actifs
EP0026289B1 (en) * 1979-07-26 1982-06-02 E.I. Du Pont De Nemours And Company Antihypertensive polyhalohydroxyisopropyl phenylalkanoic and phenylalkenoic acids, amides and esters, pharmaceutical compositions therefrom and intermediates thereto
DE3028627A1 (de) * 1980-07-29 1982-03-04 Basf Ag, 6700 Ludwigshafen 2-fluoralkancarbonsaeureverbindungen, verfahren zu ihrer herstellung, diese enthaltende herbizide und ihre anwendung
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
US6664022B1 (en) 2000-08-25 2003-12-16 Shipley Company, L.L.C. Photoacid generators and photoresists comprising same
GB0808986D0 (en) 2008-05-16 2008-06-25 Univ Newcastle Formation of 18F and 19F fluoroarenes bearing reactive functionalities
US7935269B2 (en) * 2009-05-19 2011-05-03 North American Salt Company Deicing blend and method of using the same
CN115067318B (zh) * 2022-02-22 2023-07-14 深圳中检联新药检测有限责任公司 一种牙髓间充质干细胞保存液及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3379752A (en) * 1964-05-20 1968-04-23 Merck & Co Inc Phenoxy substituted 3-hydroxyalkanoic acids and a method for their preparation
US3347910A (en) * 1964-12-10 1967-10-17 Merck & Co Inc Cycloaliphatic substituted naphthyloxy-alkanoic acids and a method for their preparation
GB1140748A (en) * 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US3721703A (en) * 1968-01-11 1973-03-20 Hoechst Ag Phenoxyalkane-carboxylic acids,salts and esters thereof
US3642869A (en) * 1969-07-30 1972-02-15 Squibb & Sons Inc 5 8-dihydronaphthyloxy acetic acids
US3740437A (en) * 1970-06-25 1973-06-19 Syntex Corp Naphthyloxyacetic acids and pharmaceutical compositions and methods thereof
DE2223894C3 (de) * 1972-05-17 1981-07-23 Hoechst Ag, 6000 Frankfurt Herbizide Mittel auf Basis von Phenoxycarbonsäurederivaten

Also Published As

Publication number Publication date
SU764608A3 (ru) 1980-09-15
IE42454L (en) 1976-06-06
NL7514070A (nl) 1976-06-09
CH618414A5 (es) 1980-07-31
CS191948B2 (en) 1979-07-31
HU170016B (es) 1977-03-28
DK546575A (da) 1976-06-07
BE836353A (fr) 1976-06-08
FR2293196A1 (fr) 1976-07-02
ES455487A1 (es) 1978-01-16
AR213278A1 (es) 1979-01-15
AT347432B (de) 1978-12-27
IE42454B1 (en) 1980-08-13
PL102292B1 (pl) 1979-03-31
CA1064498A (en) 1979-10-16
DD122963A5 (de) 1976-11-12
GB1499508A (en) 1978-02-01
PL102604B1 (pl) 1979-04-30
US4055595A (en) 1977-10-25
IL48477A (en) 1979-09-30
JPS51125227A (en) 1976-11-01
DE2554882A1 (de) 1976-06-16
ZA757089B (en) 1976-10-27
FR2293196B1 (es) 1978-07-28
ATA927475A (de) 1978-05-15
ES443237A1 (es) 1977-04-16
FI753393A7 (es) 1976-06-07
PL102241B1 (pl) 1979-03-31
NO753837L (es) 1976-06-09
IL48477A0 (en) 1976-03-31
LU73936A1 (es) 1977-02-15
AU8661975A (en) 1977-05-19
SE7513676L (sv) 1976-06-08

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