ES454468A1 - Un procedimiento para la preparacion de nuevos derivados de dibenciclohepteno. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de dibenciclohepteno.Info
- Publication number
- ES454468A1 ES454468A1 ES454468A ES454468A ES454468A1 ES 454468 A1 ES454468 A1 ES 454468A1 ES 454468 A ES454468 A ES 454468A ES 454468 A ES454468 A ES 454468A ES 454468 A1 ES454468 A1 ES 454468A1
- Authority
- ES
- Spain
- Prior art keywords
- cyproheptadine
- trifluoromethylthio
- sulfonyl
- analogs
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/642,863 US4031222A (en) | 1975-12-22 | 1975-12-22 | Trifluoromethylthio (and sulfonyl) derivatives of cyproheptadine analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES454468A1 true ES454468A1 (es) | 1978-04-16 |
Family
ID=24578354
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES454468A Expired ES454468A1 (es) | 1975-12-22 | 1976-12-21 | Un procedimiento para la preparacion de nuevos derivados de dibenciclohepteno. |
| ES466550A Expired ES466550A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466552A Expired ES466552A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466553A Expired ES466553A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466549A Expired ES466549A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466551A Expired ES466551A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466550A Expired ES466550A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466552A Expired ES466552A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466553A Expired ES466553A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466549A Expired ES466549A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
| ES466551A Expired ES466551A1 (es) | 1975-12-22 | 1978-02-01 | Un procedimiento para la preparacion de nuevos derivados de dibenzociclohepteno. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4031222A (forum.php) |
| JP (1) | JPS5278880A (forum.php) |
| AT (1) | AT363936B (forum.php) |
| AU (1) | AU506996B2 (forum.php) |
| BE (1) | BE849678A (forum.php) |
| CA (1) | CA1085823A (forum.php) |
| CH (7) | CH625790A5 (forum.php) |
| DE (1) | DE2657978C3 (forum.php) |
| DK (1) | DK550976A (forum.php) |
| ES (6) | ES454468A1 (forum.php) |
| FI (1) | FI763545A7 (forum.php) |
| FR (1) | FR2336133A1 (forum.php) |
| GB (1) | GB1519080A (forum.php) |
| GR (1) | GR62010B (forum.php) |
| HU (1) | HU175018B (forum.php) |
| IE (1) | IE44362B1 (forum.php) |
| IL (1) | IL51103A (forum.php) |
| LU (1) | LU76382A1 (forum.php) |
| NL (1) | NL7613713A (forum.php) |
| NO (1) | NO146359C (forum.php) |
| NZ (1) | NZ182868A (forum.php) |
| PH (1) | PH14088A (forum.php) |
| PL (4) | PL116941B1 (forum.php) |
| PT (1) | PT65956B (forum.php) |
| SE (1) | SE7613796L (forum.php) |
| ZA (1) | ZA767579B (forum.php) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| US4132796A (en) * | 1977-12-01 | 1979-01-02 | Merck & Co., Inc. | Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine |
| US4285956A (en) * | 1978-05-12 | 1981-08-25 | Kefalas A/S | Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith |
| US4195091A (en) * | 1978-11-15 | 1980-03-25 | Merck & Co., Inc. | Appetite stimulating pyrrolo[2,1-b][3]benzazepines |
| DK538979A (da) * | 1979-01-02 | 1980-07-03 | Merck & Co Inc | Fremgangsmaade til fremstilling af 3-halogencyproheptadiner |
| EP0019797A1 (en) * | 1979-05-21 | 1980-12-10 | Merck & Co. Inc. | Levorotatory and dextrorotatory enantiomers of 3-methoxycyproheptadine and analogs thereof, process for their preparation and antipsychotic pharmaceutical compositions |
| US4275070A (en) * | 1979-05-21 | 1981-06-23 | Merck & Co., Inc. | Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof |
| US4220651A (en) * | 1979-05-21 | 1980-09-02 | Merck & Co., Inc. | Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives |
| US5231105A (en) * | 1987-06-02 | 1993-07-27 | Ajinomoto Co., Inc. | Ethylamine derivatives and antihypertensives containing the same |
| US5393890A (en) | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
| US5114919A (en) * | 1990-02-26 | 1992-05-19 | Merck & Co., Inc. | Adjuncts in cancer chemotherapy |
| US4996321A (en) * | 1990-02-26 | 1991-02-26 | Merck & Co., Inc. | Dibenzo[a,d]cycloheptenylidene compounds |
| CN103130708B (zh) * | 2011-12-01 | 2016-08-10 | 上海药明康德新药开发有限公司 | 一种n-叔丁氧羰基-4-硝基哌啶的制备方法 |
| US20250084091A1 (en) * | 2021-05-04 | 2025-03-13 | The Texas A&M University System | Inhibitors of sars-cov-2 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3851059A (en) * | 1970-02-05 | 1974-11-26 | Merck & Co Inc | Method for the stimulation of appetite in patients |
-
1975
- 1975-12-22 US US05/642,863 patent/US4031222A/en not_active Expired - Lifetime
-
1976
- 1976-12-08 SE SE7613796A patent/SE7613796L/xx not_active Application Discontinuation
- 1976-12-08 DK DK550976A patent/DK550976A/da unknown
- 1976-12-09 FI FI763545A patent/FI763545A7/fi not_active Application Discontinuation
- 1976-12-09 NL NL7613713A patent/NL7613713A/xx unknown
- 1976-12-09 NO NO764188A patent/NO146359C/no unknown
- 1976-12-13 NZ NZ182868A patent/NZ182868A/xx unknown
- 1976-12-13 PT PT65956A patent/PT65956B/pt unknown
- 1976-12-13 HU HU76ME2035A patent/HU175018B/hu unknown
- 1976-12-14 LU LU76382A patent/LU76382A1/xx unknown
- 1976-12-14 CH CH1571276A patent/CH625790A5/de not_active IP Right Cessation
- 1976-12-14 IL IL51103A patent/IL51103A/xx unknown
- 1976-12-14 AU AU20528/76A patent/AU506996B2/en not_active Expired
- 1976-12-16 FR FR7637940A patent/FR2336133A1/fr active Granted
- 1976-12-16 GR GR52418A patent/GR62010B/el unknown
- 1976-12-16 CA CA267,998A patent/CA1085823A/en not_active Expired
- 1976-12-16 GB GB52626/76A patent/GB1519080A/en not_active Expired
- 1976-12-17 IE IE2771/76A patent/IE44362B1/en unknown
- 1976-12-20 PL PL1976222975A patent/PL116941B1/pl unknown
- 1976-12-20 PL PL1976194577A patent/PL116346B1/pl unknown
- 1976-12-20 PL PL1976222973A patent/PL116947B1/pl unknown
- 1976-12-20 AT AT0943376A patent/AT363936B/de not_active IP Right Cessation
- 1976-12-20 PL PL1976222974A patent/PL122145B1/pl unknown
- 1976-12-21 BE BE173486A patent/BE849678A/xx not_active IP Right Cessation
- 1976-12-21 PH PH19273A patent/PH14088A/en unknown
- 1976-12-21 DE DE2657978A patent/DE2657978C3/de not_active Expired
- 1976-12-21 ES ES454468A patent/ES454468A1/es not_active Expired
- 1976-12-21 ZA ZA00767579A patent/ZA767579B/xx unknown
- 1976-12-22 JP JP51153529A patent/JPS5278880A/ja active Pending
-
1978
- 1978-02-01 ES ES466550A patent/ES466550A1/es not_active Expired
- 1978-02-01 ES ES466552A patent/ES466552A1/es not_active Expired
- 1978-02-01 ES ES466553A patent/ES466553A1/es not_active Expired
- 1978-02-01 ES ES466549A patent/ES466549A1/es not_active Expired
- 1978-02-01 ES ES466551A patent/ES466551A1/es not_active Expired
-
1980
- 1980-11-26 CH CH877180A patent/CH626345A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877080A patent/CH626344A5/de not_active IP Right Cessation
- 1980-11-26 CH CH876880A patent/CH627167A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877280A patent/CH626346A5/de not_active IP Right Cessation
- 1980-11-26 CH CH876980A patent/CH626343A5/de not_active IP Right Cessation
-
1981
- 1981-06-01 CH CH357381A patent/CH631164A5/de not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES454468A1 (es) | Un procedimiento para la preparacion de nuevos derivados de dibenciclohepteno. | |
| ES472742A1 (es) | Procedimiento para la obtencion de derivados de alqueno | |
| ES2136103T3 (es) | Procedimiento para la preparacion de derivados de estaurosporina. | |
| AU589427B2 (en) | Pyridonecarboxylic acid derivatives and process for their preparation | |
| ES8406467A1 (es) | "procedimiento para preparar nuevos benzo b tiofenos". | |
| MY100095A (en) | 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition. | |
| ES482918A1 (es) | Procedimiento para la preparacion de derivados de indanilo | |
| ES434533A1 (es) | Un procedimiento para la preparacion de compuestos tetraci-clicos. | |
| SE7902100L (sv) | 1-substituerade tiometyltriazolobensodiazepiner och framstellning derav | |
| ES473925A1 (es) | Un procedimiento para la preparacion de un oligopeptido | |
| GB989013A (en) | New guanidines and process for their manufacture | |
| ES424851A1 (es) | Un procedimiento para preparar derivados de piperazina. | |
| ES472440A1 (es) | Procedimiento para fabricar derivados de 1,3-difenoxipropan -27ona. | |
| ES470757A1 (es) | Un procedimiento para la preparacion de nuevos compuestos de acidos 2-alquil(inferior)2 o 3-cefem-4-carboxilicos-7- sustituidos | |
| ES468127A1 (es) | Un procedimiento para la preparacion de nuevos derivados de pirido (2,1-b) quinazolina | |
| GB1112334A (en) | Improvements in or relating to isoquinolo[2,1-d]benzo[1,4]diazepine derivatives | |
| ES448372A1 (es) | Un procedimiento para la produccion de una solucion estable de un alcaloide ergopeptido hidrogenado. | |
| ES464000A1 (es) | Un procedimiento para preparar nuevas beta-lactamas monoci- clicas con actividad antibacteriana. | |
| ES8400384A1 (es) | Procedimiento para la preparacion de derivados de carbaciclina. | |
| GB1091109A (en) | New derivative of phenylbutazone and its preparation | |
| ES8504174A1 (es) | Un procedimiento para la preparacion de derivados de pirazolo-quinolinas. | |
| GB1245155A (en) | NOVEL 5-SUBSTITUTED-gamma-CARBOLINE DERIVATIVES AND THE SALTS THEREOF | |
| CH614941A5 (en) | Process for the preparation of new terpenoaromatic amidines | |
| GB1199758A (en) | Arylsulphonyl-Semicarbazides and their production | |
| GB952547A (en) | Improvements in or relating to novel substituted phenylalkylamines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991108 |