ES450601A1 - Un procedimiento para la preparacion de nuevos derivados de 4,5-diaril-2-(tiosustituido) michazol. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de 4,5-diaril-2-(tiosustituido) michazol.Info
- Publication number
- ES450601A1 ES450601A1 ES450601A ES450601A ES450601A1 ES 450601 A1 ES450601 A1 ES 450601A1 ES 450601 A ES450601 A ES 450601A ES 450601 A ES450601 A ES 450601A ES 450601 A1 ES450601 A1 ES 450601A1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- inflammatory
- compounds
- useful
- unique properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010003246 arthritis Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 229940124589 immunosuppressive drug Drugs 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60365075A | 1975-08-11 | 1975-08-11 | |
| US69128276A | 1976-06-09 | 1976-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES450601A1 true ES450601A1 (es) | 1978-01-16 |
Family
ID=27084480
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES450601A Expired ES450601A1 (es) | 1975-08-11 | 1976-08-10 | Un procedimiento para la preparacion de nuevos derivados de 4,5-diaril-2-(tiosustituido) michazol. |
| ES461193A Expired ES461193A1 (es) | 1975-08-11 | 1977-07-28 | Un procedimiento para la preparacion de nuevos derivados de 4,5diaril-2-(tio sustituido) imidazol. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461193A Expired ES461193A1 (es) | 1975-08-11 | 1977-07-28 | Un procedimiento para la preparacion de nuevos derivados de 4,5diaril-2-(tio sustituido) imidazol. |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS6011702B2 (cs) |
| AR (2) | AR215591A1 (cs) |
| AU (1) | AU508605B2 (cs) |
| CA (1) | CA1074327A (cs) |
| CH (1) | CH638791A5 (cs) |
| DD (1) | DD126244A5 (cs) |
| DE (1) | DE2635876A1 (cs) |
| DK (1) | DK361376A (cs) |
| ES (2) | ES450601A1 (cs) |
| FI (1) | FI66177C (cs) |
| FR (1) | FR2320745A1 (cs) |
| GB (1) | GB1516908A (cs) |
| GR (1) | GR61145B (cs) |
| HU (1) | HU174707B (cs) |
| IE (1) | IE44019B1 (cs) |
| IL (1) | IL50230A (cs) |
| LU (1) | LU75578A1 (cs) |
| MX (1) | MX3932E (cs) |
| NL (1) | NL7608915A (cs) |
| NO (1) | NO146571C (cs) |
| NZ (1) | NZ181731A (cs) |
| PH (1) | PH11857A (cs) |
| PT (1) | PT65464B (cs) |
| SE (1) | SE428686B (cs) |
| SU (1) | SU640662A3 (cs) |
| YU (1) | YU198176A (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK16778A (da) * | 1977-02-09 | 1978-08-10 | Du Pont | Imidazolderivater deres anvendelser og fremstilling |
| LU77703A1 (de) * | 1977-07-07 | 1979-03-26 | Ciba Geigy Ag | Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen |
| CY1302A (en) * | 1978-04-11 | 1985-12-06 | Ciba Geigy Ag | Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications |
| DE2823197A1 (de) | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4308277A (en) * | 1978-08-10 | 1981-12-29 | Ciba-Geigy Corporation | 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same |
| US4188397A (en) * | 1978-09-22 | 1980-02-12 | Smithkline Corporation | 2,2-Alkyldiylbis(thio)bis(imidazoles) |
| US4215135A (en) * | 1979-06-08 | 1980-07-29 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles |
| DE2856909A1 (de) | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| GB8907656D0 (en) * | 1989-04-05 | 1989-05-17 | May & Baker Ltd | New compositions of matter |
| FI971234A7 (fi) * | 1994-09-26 | 1997-05-23 | Shionogi & Co | Imidatsolijohdannainen |
| IL133766A0 (en) * | 1997-06-30 | 2001-04-30 | Ortho Mcneil Pharm Inc | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| DE10222103A1 (de) * | 2002-05-17 | 2003-11-27 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| ES2393621T3 (es) * | 2006-02-06 | 2012-12-26 | Taisho Pharmaceutical Co., Ltd | Inhibidor de unión de esfingosina-1-fosfato |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1509975A (fr) * | 1965-10-21 | 1968-01-19 | Geigy Ag J R | Dérivés de l'imidazole et leur préparation |
| US3651080A (en) * | 1969-11-07 | 1972-03-21 | Ciba Geigy Corp | Certain substituted 2-alkylmercaptoimidazole derivatives |
| US3636003A (en) * | 1969-11-17 | 1972-01-18 | Geigy Chem Corp | Substituted 2-mercaptoimidazole derivatives |
| US3714179A (en) * | 1970-09-08 | 1973-01-30 | Searle & Co | 1-alkyl-2-furfurylthioimidazoles and congeners |
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
-
1976
- 1976-07-02 SE SE7607615A patent/SE428686B/xx not_active IP Right Cessation
- 1976-08-05 MX MX762132U patent/MX3932E/es unknown
- 1976-08-09 NO NO762754A patent/NO146571C/no unknown
- 1976-08-09 CA CA258,690A patent/CA1074327A/en not_active Expired
- 1976-08-09 DD DD194248A patent/DD126244A5/xx unknown
- 1976-08-10 PH PH18773A patent/PH11857A/en unknown
- 1976-08-10 FI FI762290A patent/FI66177C/fi not_active IP Right Cessation
- 1976-08-10 ES ES450601A patent/ES450601A1/es not_active Expired
- 1976-08-10 CH CH1019276A patent/CH638791A5/de not_active IP Right Cessation
- 1976-08-10 PT PT65464A patent/PT65464B/pt unknown
- 1976-08-10 HU HU76DU252A patent/HU174707B/hu unknown
- 1976-08-10 DK DK361376A patent/DK361376A/da not_active Application Discontinuation
- 1976-08-10 DE DE19762635876 patent/DE2635876A1/de not_active Withdrawn
- 1976-08-10 GB GB33286/76A patent/GB1516908A/en not_active Expired
- 1976-08-10 GR GR51440A patent/GR61145B/el unknown
- 1976-08-10 IL IL50230A patent/IL50230A/xx unknown
- 1976-08-10 FR FR7624400A patent/FR2320745A1/fr active Granted
- 1976-08-10 SU SU762388413A patent/SU640662A3/ru active
- 1976-08-10 AU AU16711/76A patent/AU508605B2/en not_active Expired
- 1976-08-10 NZ NZ181737A patent/NZ181731A/xx unknown
- 1976-08-11 NL NL7608915A patent/NL7608915A/xx not_active Application Discontinuation
- 1976-08-11 LU LU75578A patent/LU75578A1/xx unknown
- 1976-08-11 JP JP51094991A patent/JPS6011702B2/ja not_active Expired
- 1976-08-11 AR AR264308A patent/AR215591A1/es active
- 1976-08-11 YU YU01981/76A patent/YU198176A/xx unknown
- 1976-08-11 IE IE1775/76A patent/IE44019B1/en unknown
-
1977
- 1977-07-28 ES ES461193A patent/ES461193A1/es not_active Expired
-
1978
- 1978-01-10 AR AR270672A patent/AR218054A1/es active
Also Published As
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