IE44019L - 4, 5-diaryl imidazoles - Google Patents

4, 5-diaryl imidazoles

Info

Publication number
IE44019L
IE44019L IE761775A IE177576A IE44019L IE 44019 L IE44019 L IE 44019L IE 761775 A IE761775 A IE 761775A IE 177576 A IE177576 A IE 177576A IE 44019 L IE44019 L IE 44019L
Authority
IE
Ireland
Prior art keywords
imidazoles
alkyl
diaryl
different
same
Prior art date
Application number
IE761775A
Other versions
IE44019B1 (en
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of IE44019L publication Critical patent/IE44019L/en
Publication of IE44019B1 publication Critical patent/IE44019B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Anti-inflammatory 4,5-diaryl-2-(substituted-thio)-imidazoles and their corresponding dulcoxides and sulfones, which are useful for treating arthritis and related diseases, are disclosed. The imidazoles are of the formula where n = 0-3; R1 is alkyl, allyl, vinyl, -CH2COCH3, CH2S(O)mCH3 where m is 0-2, mono- or polyhaloalkyl; and R2 and R3, the same or different, are where Y1 and Y2, the same or different, are hydrogen, hydroxy, alkyl and specified halogen and halogen-, nitrogen-, oxygenand/or sulfur-substituted radicals. [CA1074327A]
IE1775/76A 1975-08-11 1976-08-11 4,5-diaryl substituted imidazoles IE44019B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60365075A 1975-08-11 1975-08-11
US69128276A 1976-06-09 1976-06-09

Publications (2)

Publication Number Publication Date
IE44019L true IE44019L (en) 1977-02-11
IE44019B1 IE44019B1 (en) 1981-07-29

Family

ID=27084480

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1775/76A IE44019B1 (en) 1975-08-11 1976-08-11 4,5-diaryl substituted imidazoles

Country Status (26)

Country Link
JP (1) JPS6011702B2 (en)
AR (2) AR215591A1 (en)
AU (1) AU508605B2 (en)
CA (1) CA1074327A (en)
CH (1) CH638791A5 (en)
DD (1) DD126244A5 (en)
DE (1) DE2635876A1 (en)
DK (1) DK361376A (en)
ES (2) ES450601A1 (en)
FI (1) FI66177C (en)
FR (1) FR2320745A1 (en)
GB (1) GB1516908A (en)
GR (1) GR61145B (en)
HU (1) HU174707B (en)
IE (1) IE44019B1 (en)
IL (1) IL50230A (en)
LU (1) LU75578A1 (en)
MX (1) MX3932E (en)
NL (1) NL7608915A (en)
NO (1) NO146571C (en)
NZ (1) NZ181731A (en)
PH (1) PH11857A (en)
PT (1) PT65464B (en)
SE (1) SE428686B (en)
SU (1) SU640662A3 (en)
YU (1) YU198176A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK16778A (en) * 1977-02-09 1978-08-10 Du Pont IMIDAZOLE DERIVATIVES THEIR USES AND MANUFACTURE
LU77703A1 (en) * 1977-07-07 1979-03-26 Ciba Geigy Ag METHOD FOR PRODUCING BICYCLIC THIA-DIAZA COMPOUNDS
DE2963572D1 (en) * 1978-04-11 1982-10-21 Ciba Geigy Ag Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions
DE2823197A1 (en) 1978-05-24 1979-11-29 Schering Ag NEW IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4188397A (en) * 1978-09-22 1980-02-12 Smithkline Corporation 2,2-Alkyldiylbis(thio)bis(imidazoles)
US4215135A (en) * 1979-06-08 1980-07-29 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
DE2856909A1 (en) * 1978-12-28 1980-07-17 Schering Ag NEW IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
GB8907656D0 (en) * 1989-04-05 1989-05-17 May & Baker Ltd New compositions of matter
AU8757098A (en) * 1997-06-30 1999-02-10 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE10222103A1 (en) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik New 2-(substituted thio)-imidazole derivatives are immunomodulators and cytokine release inhibitors, useful for treating diseases associated with immune system disorders, e.g. cancer or rheumatoid arthritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120426B (en) * 1965-10-21 1970-10-19 Geigy Ag J R
US3651080A (en) * 1969-11-07 1972-03-21 Ciba Geigy Corp Certain substituted 2-alkylmercaptoimidazole derivatives
US3636003A (en) * 1969-11-17 1972-01-18 Geigy Chem Corp Substituted 2-mercaptoimidazole derivatives
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles

Also Published As

Publication number Publication date
NO146571B (en) 1982-07-19
ES450601A1 (en) 1978-01-16
NZ181731A (en) 1978-11-13
AR218054A1 (en) 1980-05-15
DD126244A5 (en) 1977-07-06
IL50230A0 (en) 1976-10-31
LU75578A1 (en) 1978-04-13
FR2320745A1 (en) 1977-03-11
AU508605B2 (en) 1980-03-27
AR215591A1 (en) 1979-10-31
PT65464A (en) 1976-09-01
PT65464B (en) 1978-08-02
AU1671176A (en) 1978-02-16
GR61145B (en) 1978-09-27
SU640662A3 (en) 1978-12-30
FI762290A (en) 1977-02-12
PH11857A (en) 1978-08-03
CH638791A5 (en) 1983-10-14
NO146571C (en) 1982-10-27
SE428686B (en) 1983-07-18
HU174707B (en) 1980-03-28
FI66177B (en) 1984-05-31
CA1074327A (en) 1980-03-25
JPS5223076A (en) 1977-02-21
FI66177C (en) 1984-09-10
ES461193A1 (en) 1978-12-01
SE7607615L (en) 1977-02-12
NL7608915A (en) 1977-02-15
MX3932E (en) 1981-10-02
FR2320745B1 (en) 1978-12-22
GB1516908A (en) 1978-07-05
DK361376A (en) 1977-02-12
IL50230A (en) 1979-07-25
JPS6011702B2 (en) 1985-03-27
IE44019B1 (en) 1981-07-29
DE2635876A1 (en) 1977-03-03
YU198176A (en) 1982-10-31
NO762754L (en) 1977-02-14

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