ES443519A1 - Benzoisoindoline derivatives - Google Patents
Benzoisoindoline derivativesInfo
- Publication number
- ES443519A1 ES443519A1 ES443519A ES443519A ES443519A1 ES 443519 A1 ES443519 A1 ES 443519A1 ES 443519 A ES443519 A ES 443519A ES 443519 A ES443519 A ES 443519A ES 443519 A1 ES443519 A1 ES 443519A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- alkyl
- halogen
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for obtaining benz [f] isoindoline derivatives of formula Ia, ** (See formula) ** which, according to the definition, also includes the optic antipodes of the compounds of formula Ia, as well as the racemic mixtures of these optical antipodes, in which formula R1 and R2 which are the same or different, each represent hydrogen, halogen or alkyl of 1 to 4 carbon atoms, each of X and Y being hydrogen, in which case rings B and C are linked by a cis bond, or X and Y together form an additional bond, and R4 is alkyl of 1 to 4 5 carbon atoms, alkenyl or alkynyl of 3 to 5 carbon atoms, the multiple bond thereof not being in the alpha position with respect to the nitrogen atom to which R4 is attached, alkyl of 1 to 4 carbon atoms substituted by cycloalkyl of 3 to 6 carbon atoms, hydroxyalkyl of 2 to 5 carbon atoms, phenylalkyl of 7 to 11 carbon atoms, phenylalkyl of 7 to 11 carbon atoms monosubstituted in the phenyl radical by halogen, alkoxy of 1 to 4 carbon atoms or alkyl of 1 to 4 carbon atoms, or a radical A-CO-R3, where A is alkylene of 1 to 4 carbon atoms and R3 is alkyl of 1 to 5 carbon atoms, hydroxy or alkoxy of 1 to 4 carbon atoms, phenyl, phenyl monosubstituted by halogen; and the salts thereof; characterized by comprising: N-rent a compound of formula Ib, ** (See formula) ** which, and according to the definition, also includes the optical antipodes of these compounds of formula Ib, as well as the racemic mixtures of said optical antipodes, in which formula R1, R2, X and Y are defined as above, conveniently in a solvent, preferably between room temperature and reflux temperature. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1425072A CH590231A5 (en) | 1972-09-29 | 1972-09-29 | Benzo(f)isoindoline derivs - with antidepressant and analgesic activity |
| CH1130573A CH605748A5 (en) | 1973-08-03 | 1973-08-03 | Benzo(f)isoindoline derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443519A1 true ES443519A1 (en) | 1977-08-16 |
Family
ID=25708104
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES419195A Expired ES419195A1 (en) | 1972-09-29 | 1973-09-29 | Benzoisoindoline derivatives |
| ES443519A Expired ES443519A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
| ES443518A Expired ES443518A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES419195A Expired ES419195A1 (en) | 1972-09-29 | 1973-09-29 | Benzoisoindoline derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
| ES443518A Expired ES443518A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS602304B2 (en) |
| AT (1) | AT339891B (en) |
| CA (1) | CA1008865A (en) |
| DD (2) | DD118630A5 (en) |
| DE (1) | DE2348593A1 (en) |
| DK (1) | DK136420B (en) |
| ES (4) | ES419195A1 (en) |
| FI (1) | FI57748C (en) |
| FR (1) | FR2201092B1 (en) |
| GB (1) | GB1449159A (en) |
| HK (1) | HK380A (en) |
| IE (1) | IE39474B1 (en) |
| IL (1) | IL43333A (en) |
| MY (1) | MY8000220A (en) |
| NL (1) | NL7313111A (en) |
| PH (1) | PH12933A (en) |
| SE (1) | SE394110B (en) |
| SU (1) | SU707521A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000154B1 (en) * | 1977-06-28 | 1981-07-29 | Sandoz Ag | New benz(f)isoindolines, their preparation and medicaments containing them |
| FR2791345B1 (en) * | 1999-03-26 | 2001-05-04 | Adir | NOVEL BENZO [3,4] CYCLOBUTA [1,2-C] PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792374A (en) * | 1971-12-08 | 1973-06-06 | Allen & Hanburys Ltd | NEW DERIVATIVES OF ISOINDOLINE |
-
1973
- 1973-09-20 FI FI2934/73A patent/FI57748C/en active
- 1973-09-20 DK DK516373AA patent/DK136420B/en not_active IP Right Cessation
- 1973-09-21 SE SE7312916A patent/SE394110B/en unknown
- 1973-09-24 NL NL7313111A patent/NL7313111A/xx not_active Application Discontinuation
- 1973-09-26 DD DD187137*A patent/DD118630A5/xx unknown
- 1973-09-26 IL IL43333A patent/IL43333A/en unknown
- 1973-09-26 DD DD173691A patent/DD114604A5/xx unknown
- 1973-09-27 IE IE1730/73A patent/IE39474B1/en unknown
- 1973-09-27 DE DE19732348593 patent/DE2348593A1/en not_active Withdrawn
- 1973-09-28 FR FR7334863A patent/FR2201092B1/fr not_active Expired
- 1973-09-28 JP JP48108577A patent/JPS602304B2/en not_active Expired
- 1973-09-28 CA CA182,178A patent/CA1008865A/en not_active Expired
- 1973-09-28 GB GB4547773A patent/GB1449159A/en not_active Expired
- 1973-09-28 AT AT833873A patent/AT339891B/en not_active IP Right Cessation
- 1973-09-29 ES ES419195A patent/ES419195A1/en not_active Expired
- 1973-10-01 PH PH15069A patent/PH12933A/en unknown
-
1975
- 1975-12-16 ES ES443519A patent/ES443519A1/en not_active Expired
- 1975-12-16 ES ES443517A patent/ES443517A1/en not_active Expired
- 1975-12-16 ES ES443518A patent/ES443518A1/en not_active Expired
-
1976
- 1976-10-28 SU SU762415454A patent/SU707521A3/en active
-
1980
- 1980-01-03 HK HK3/80A patent/HK380A/en unknown
- 1980-12-30 MY MY220/80A patent/MY8000220A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES419195A1 (en) | 1976-12-16 |
| IL43333A0 (en) | 1973-11-28 |
| IL43333A (en) | 1978-10-31 |
| IE39474L (en) | 1974-03-29 |
| DE2348593A1 (en) | 1974-04-11 |
| JPS602304B2 (en) | 1985-01-21 |
| AT339891B (en) | 1977-11-10 |
| GB1449159A (en) | 1976-09-15 |
| DD114604A5 (en) | 1975-08-12 |
| NL7313111A (en) | 1974-04-02 |
| SE394110B (en) | 1977-06-06 |
| IE39474B1 (en) | 1978-10-25 |
| PH12933A (en) | 1979-10-17 |
| FI57748C (en) | 1980-10-10 |
| CA1008865A (en) | 1977-04-19 |
| FI57748B (en) | 1980-06-30 |
| SU707521A3 (en) | 1979-12-30 |
| ATA833873A (en) | 1977-02-15 |
| FR2201092A1 (en) | 1974-04-26 |
| AU6085273A (en) | 1975-04-10 |
| DK136420B (en) | 1977-10-10 |
| FR2201092B1 (en) | 1977-09-09 |
| MY8000220A (en) | 1980-12-31 |
| HK380A (en) | 1980-01-11 |
| ES443517A1 (en) | 1977-08-16 |
| ES443518A1 (en) | 1977-08-01 |
| DK136420C (en) | 1978-03-13 |
| JPS4970960A (en) | 1974-07-09 |
| DD118630A5 (en) | 1976-03-12 |
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