ES443518A1 - Benzoisoindoline derivatives - Google Patents
Benzoisoindoline derivativesInfo
- Publication number
- ES443518A1 ES443518A1 ES443518A ES443518A ES443518A1 ES 443518 A1 ES443518 A1 ES 443518A1 ES 443518 A ES443518 A ES 443518A ES 443518 A ES443518 A ES 443518A ES 443518 A1 ES443518 A1 ES 443518A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- carbon
- formula
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedure for obtaining benz [f] isoindoline derivatives of formula Im, **(See formula)** as well as their optical antipodes and the racemic mixtures of these optical antipodes, in whose formula R1 and R2 that are the same or different, each represent hydrogen, halogen or alkyl of 1 to 4 carbon atoms, each of X and Y is hydrogen, in which rings B and C are linked by a cis bond, or E to Y together form an additional bond, D is hydrogen, alkyl of 1 to 4 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, 1 to 3 carbon alkyl substituted by 3 to 6 carbon cycloalkyl, 1 to 4 carbon atoms hydroxyalkyl, phenyl, 7 to 10 carbon atom alkyl, halogen monosubstituted phenyl, 1 to 4 atom alkoxy carbon or alkyl of 1 to 4 carbon atoms, or phenylalkyl of 7 to 10 carbon atoms monosubstituted in the phenyl radical by halogen, alkoxy of 1 to 4 carbon atoms or lower alkyl of 1 to 4 carbon atoms, characterized by that a compound of formula is reduced IV, **(See formula)** wherein X, Y, D, R1 and R2 are as defined above, conveniently in a solvent, preferably between room temperature and reflux temperature. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1425072A CH590231A5 (en) | 1972-09-29 | 1972-09-29 | Benzo(f)isoindoline derivs - with antidepressant and analgesic activity |
| CH1130573A CH605748A5 (en) | 1973-08-03 | 1973-08-03 | Benzo(f)isoindoline derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443518A1 true ES443518A1 (en) | 1977-08-01 |
Family
ID=25708104
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES419195A Expired ES419195A1 (en) | 1972-09-29 | 1973-09-29 | Benzoisoindoline derivatives |
| ES443519A Expired ES443519A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
| ES443518A Expired ES443518A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES419195A Expired ES419195A1 (en) | 1972-09-29 | 1973-09-29 | Benzoisoindoline derivatives |
| ES443519A Expired ES443519A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443517A Expired ES443517A1 (en) | 1972-09-29 | 1975-12-16 | Benzoisoindoline derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS602304B2 (en) |
| AT (1) | AT339891B (en) |
| CA (1) | CA1008865A (en) |
| DD (2) | DD118630A5 (en) |
| DE (1) | DE2348593A1 (en) |
| DK (1) | DK136420B (en) |
| ES (4) | ES419195A1 (en) |
| FI (1) | FI57748C (en) |
| FR (1) | FR2201092B1 (en) |
| GB (1) | GB1449159A (en) |
| HK (1) | HK380A (en) |
| IE (1) | IE39474B1 (en) |
| IL (1) | IL43333A (en) |
| MY (1) | MY8000220A (en) |
| NL (1) | NL7313111A (en) |
| PH (1) | PH12933A (en) |
| SE (1) | SE394110B (en) |
| SU (1) | SU707521A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860878D1 (en) * | 1977-06-28 | 1981-10-29 | Sandoz Ag | New benz(f)isoindolines, their preparation and medicaments containing them |
| FR2791345B1 (en) * | 1999-03-26 | 2001-05-04 | Adir | NOVEL BENZO [3,4] CYCLOBUTA [1,2-C] PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792374A (en) * | 1971-12-08 | 1973-06-06 | Allen & Hanburys Ltd | NEW DERIVATIVES OF ISOINDOLINE |
-
1973
- 1973-09-20 FI FI2934/73A patent/FI57748C/en active
- 1973-09-20 DK DK516373AA patent/DK136420B/en not_active IP Right Cessation
- 1973-09-21 SE SE7312916A patent/SE394110B/en unknown
- 1973-09-24 NL NL7313111A patent/NL7313111A/xx not_active Application Discontinuation
- 1973-09-26 DD DD187137*A patent/DD118630A5/xx unknown
- 1973-09-26 IL IL43333A patent/IL43333A/en unknown
- 1973-09-26 DD DD173691A patent/DD114604A5/xx unknown
- 1973-09-27 IE IE1730/73A patent/IE39474B1/en unknown
- 1973-09-27 DE DE19732348593 patent/DE2348593A1/en not_active Withdrawn
- 1973-09-28 CA CA182,178A patent/CA1008865A/en not_active Expired
- 1973-09-28 FR FR7334863A patent/FR2201092B1/fr not_active Expired
- 1973-09-28 GB GB4547773A patent/GB1449159A/en not_active Expired
- 1973-09-28 JP JP48108577A patent/JPS602304B2/en not_active Expired
- 1973-09-28 AT AT833873A patent/AT339891B/en not_active IP Right Cessation
- 1973-09-29 ES ES419195A patent/ES419195A1/en not_active Expired
- 1973-10-01 PH PH15069A patent/PH12933A/en unknown
-
1975
- 1975-12-16 ES ES443519A patent/ES443519A1/en not_active Expired
- 1975-12-16 ES ES443518A patent/ES443518A1/en not_active Expired
- 1975-12-16 ES ES443517A patent/ES443517A1/en not_active Expired
-
1976
- 1976-10-28 SU SU762415454A patent/SU707521A3/en active
-
1980
- 1980-01-03 HK HK3/80A patent/HK380A/en unknown
- 1980-12-30 MY MY220/80A patent/MY8000220A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES443519A1 (en) | 1977-08-16 |
| IL43333A0 (en) | 1973-11-28 |
| FR2201092A1 (en) | 1974-04-26 |
| IE39474L (en) | 1974-03-29 |
| JPS4970960A (en) | 1974-07-09 |
| HK380A (en) | 1980-01-11 |
| FR2201092B1 (en) | 1977-09-09 |
| FI57748C (en) | 1980-10-10 |
| JPS602304B2 (en) | 1985-01-21 |
| DE2348593A1 (en) | 1974-04-11 |
| AU6085273A (en) | 1975-04-10 |
| AT339891B (en) | 1977-11-10 |
| MY8000220A (en) | 1980-12-31 |
| DD118630A5 (en) | 1976-03-12 |
| CA1008865A (en) | 1977-04-19 |
| ATA833873A (en) | 1977-02-15 |
| ES419195A1 (en) | 1976-12-16 |
| FI57748B (en) | 1980-06-30 |
| ES443517A1 (en) | 1977-08-16 |
| DD114604A5 (en) | 1975-08-12 |
| GB1449159A (en) | 1976-09-15 |
| SE394110B (en) | 1977-06-06 |
| IE39474B1 (en) | 1978-10-25 |
| IL43333A (en) | 1978-10-31 |
| DK136420B (en) | 1977-10-10 |
| DK136420C (en) | 1978-03-13 |
| SU707521A3 (en) | 1979-12-30 |
| PH12933A (en) | 1979-10-17 |
| NL7313111A (en) | 1974-04-02 |
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