ES424501A1 - A procedure for preparing 1,2-acetonides of 3- (tiazol2-oxi-4- o 5-substituted) -propanodiol. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing 1,2-acetonides of 3- (tiazol2-oxi-4- o 5-substituted) -propanodiol. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES424501A1 ES424501A1 ES424501A ES424501A ES424501A1 ES 424501 A1 ES424501 A1 ES 424501A1 ES 424501 A ES424501 A ES 424501A ES 424501 A ES424501 A ES 424501A ES 424501 A1 ES424501 A1 ES 424501A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- alkyl
- substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
A procedure for the preparation of a compound of formulas: **(See formula)** where the groups (see formula) are in position 4 or 5 of the thiazole ring and R4 is selected from the group of alkyls having from 1 to 12 carbon atoms; cycloalkyls having 3 to 12 carbon atoms; phenyl; phenylalkyl in which said alkyl has 1 to 6 carbon atoms, or substituted phenyl or substituted lower phenylalkyl in which said phenyl has 1 or 2 substituents independently selected from the group consisting of hydroxyl, lower alkyl, lower alkoxy, or halogen; a terminally substituted alkyl group having from two to 12 carbon atoms with a terminal carbon atom substituted with a substituent selected from the group consisting of hydroxyl, acyloxy having from 2 to 12 carbon atoms, and alkoxy having from from to 6 atoms carbon; and groups having the formulas (CH2) n + 1NR8R9 or - (CH2) n 10 where n is an integer from 1 to 4, R8 and R9 are independently selected from the group consisting of hydrogen and alkyl groups having 1 to 4 carbon atoms and R10 is cycloalkyl having 3 to 8 carbon atoms, comprising a) heating 3- (5-azidocarbonylthiazol-2-oxy) -2 propanediol 1,2 acetonide optionally with an alcohol R4OH with an inert aromatic solvent at temperatures from about 95ºC to about 120ºC to give the corresponding compound of formula (F); b) heating 3- (5-azidocarbonylthiazol-2-oxy) -2-propanediol 1,2-acetonide in an inert aromatic solvent at a temperature of around 100ºC to around 110ºC to give the corresponding product 5- or -4- isocyanothothiazole and react said product with a compound selected from the group having the formulas: R4MgX'O R4'Li where X' is chloride, bromide or iodide, R4 has the above significance and R'4 is an alkyl having from 1 to 12 carbon atoms; a cycloalkyl having 3 to 12 carbon atoms; a phenyl; a lower phenylalkyl in which said alkyl has from 1 to 6 carbon atoms or the group having the formula - (CH2) n R5 in which n is an integer from 1 to 4 and R5 is a cycloalkyl having between 3 and 8 carbon atoms, in an inert solvent at a temperature of from about -100ºC to about -78ºC to give the corresponding compound of formula (E). (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US451194A US3896139A (en) | 1974-03-14 | 1974-03-14 | Process for preparing 3-(4-or-5-azidocarbonylthiazol-2-oxy)-propanediol-1,2-acetonides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES424501A1 true ES424501A1 (en) | 1976-09-01 |
Family
ID=23791184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES424501A Expired ES424501A1 (en) | 1974-03-14 | 1974-03-21 | A procedure for preparing 1,2-acetonides of 3- (tiazol2-oxi-4- o 5-substituted) -propanodiol. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES424501A1 (en) |
| ZA (1) | ZA741808B (en) |
-
1974
- 1974-03-19 ZA ZA00741808A patent/ZA741808B/en unknown
- 1974-03-21 ES ES424501A patent/ES424501A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA741808B (en) | 1975-11-26 |
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