ES442144A1 - Un procedimiento para la preparacion de 4'-epi-6'-hidroxida-unomicina. - Google Patents
Un procedimiento para la preparacion de 4'-epi-6'-hidroxida-unomicina.Info
- Publication number
- ES442144A1 ES442144A1 ES442144A ES442144A ES442144A1 ES 442144 A1 ES442144 A1 ES 442144A1 ES 442144 A ES442144 A ES 442144A ES 442144 A ES442144 A ES 442144A ES 442144 A1 ES442144 A1 ES 442144A1
- Authority
- ES
- Spain
- Prior art keywords
- epi
- hydroxyadriamycin
- novel
- hydroxydaunomycin
- daunomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182470 glycoside Natural products 0.000 abstract 3
- 150000002338 glycosides Chemical class 0.000 abstract 3
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 2
- MMNLCGHZNCRLMM-UHFFFAOYSA-N 7-[4-amino-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(=O)CO)CC1OC1CC(N)C(O)C(CO)O1 MMNLCGHZNCRLMM-UHFFFAOYSA-N 0.000 abstract 2
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 2
- PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4664474A GB1470860A (en) | 1974-10-29 | 1974-10-29 | Anthracycline glycosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES442144A1 true ES442144A1 (es) | 1977-08-01 |
Family
ID=10442049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES442144A Expired ES442144A1 (es) | 1974-10-29 | 1975-10-28 | Un procedimiento para la preparacion de 4'-epi-6'-hidroxida-unomicina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4025623A (en, 2012) |
| JP (2) | JPS5951559B2 (en, 2012) |
| AT (1) | AT340591B (en, 2012) |
| AU (1) | AU498511B2 (en, 2012) |
| BE (1) | BE834939A (en, 2012) |
| CA (1) | CA1046509A (en, 2012) |
| CH (2) | CH618707A5 (en, 2012) |
| DE (1) | DE2548087A1 (en, 2012) |
| DK (1) | DK146803C (en, 2012) |
| ES (1) | ES442144A1 (en, 2012) |
| FR (1) | FR2289203A1 (en, 2012) |
| GB (1) | GB1470860A (en, 2012) |
| NL (1) | NL7512489A (en, 2012) |
| SE (1) | SE423996B (en, 2012) |
| SU (2) | SU646913A3 (en, 2012) |
| YU (2) | YU37119B (en, 2012) |
| ZA (1) | ZA756732B (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1506200A (en) * | 1975-04-30 | 1978-04-05 | Farmaceutici Italia | Glycosides |
| GB1502121A (en) * | 1975-08-02 | 1978-02-22 | Farmaceutici Italia | Anthracyclines |
| GB1524468A (en) * | 1976-07-13 | 1978-09-13 | Farmaceutici Italia | Anthracylines |
| GB1561507A (en) * | 1976-11-17 | 1980-02-20 | Farmaceutici Italia | Snthracycline disaccharides |
| GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
| US4181795A (en) * | 1978-05-22 | 1980-01-01 | Purdue Research Foundation | Daunosamine synthesis |
| US4203976A (en) * | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4303785A (en) * | 1978-08-05 | 1981-12-01 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Antitumor anthracycline antibiotics |
| JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
| JPS6130464U (ja) * | 1984-07-26 | 1986-02-24 | 武夫 安田 | 食器洗い用具 |
| JPH01207028A (ja) * | 1987-02-09 | 1989-08-21 | Tomiko Saito | タワシと容器 |
| JPH0261920U (en, 2012) * | 1988-10-28 | 1990-05-09 | ||
| JP3035035U (ja) * | 1996-04-26 | 1997-03-11 | 裕敬 丸子 | 把手のあるスポンジ |
| ES2356284T3 (es) * | 1997-12-05 | 2011-04-06 | Mercian Corporation | Antibiótico de antraciclina cristalino y procedimiento para su producción. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803124A (en) * | 1968-04-12 | 1974-04-09 | Farmaceutici It Soc | Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives |
| BE793976A (fr) * | 1972-01-13 | 1973-05-02 | Parke Davis & Co | Nouvelles polyamines et procede pour les preparer |
-
1974
- 1974-10-29 GB GB4664474A patent/GB1470860A/en not_active Expired
-
1975
- 1975-10-10 US US05/621,582 patent/US4025623A/en not_active Expired - Lifetime
- 1975-10-24 NL NL7512489A patent/NL7512489A/xx not_active Application Discontinuation
- 1975-10-24 AT AT812975A patent/AT340591B/de not_active IP Right Cessation
- 1975-10-24 YU YU2695/75A patent/YU37119B/xx unknown
- 1975-10-27 AU AU86040/75A patent/AU498511B2/en not_active Expired
- 1975-10-27 ZA ZA00756732A patent/ZA756732B/xx unknown
- 1975-10-27 DK DK482175A patent/DK146803C/da not_active IP Right Cessation
- 1975-10-27 SU SU752184006A patent/SU646913A3/ru active
- 1975-10-27 SE SE7512005A patent/SE423996B/xx unknown
- 1975-10-27 FR FR7532753A patent/FR2289203A1/fr active Granted
- 1975-10-28 ES ES442144A patent/ES442144A1/es not_active Expired
- 1975-10-28 JP JP50128991A patent/JPS5951559B2/ja not_active Expired
- 1975-10-28 CH CH1395075A patent/CH618707A5/de not_active IP Right Cessation
- 1975-10-28 DE DE19752548087 patent/DE2548087A1/de not_active Withdrawn
- 1975-10-28 BE BE161309A patent/BE834939A/xx not_active IP Right Cessation
- 1975-10-28 CA CA238,713A patent/CA1046509A/en not_active Expired
-
1976
- 1976-08-10 SU SU762387269A patent/SU628822A3/ru active
-
1980
- 1980-02-06 CH CH94680A patent/CH621799A5/de not_active IP Right Cessation
-
1981
- 1981-12-14 YU YU02933/81A patent/YU293381A/xx unknown
-
1983
- 1983-11-11 JP JP58211116A patent/JPS6056720B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5951559B2 (ja) | 1984-12-14 |
| AT340591B (de) | 1977-12-27 |
| FR2289203A1 (fr) | 1976-05-28 |
| NL7512489A (nl) | 1976-05-04 |
| SU628822A3 (ru) | 1978-10-15 |
| SE423996B (sv) | 1982-06-21 |
| DK146803C (da) | 1984-06-18 |
| GB1470860A (en) | 1977-04-21 |
| SE7512005L (sv) | 1976-04-30 |
| AU8604075A (en) | 1977-05-05 |
| YU269575A (en) | 1983-04-27 |
| CH621799A5 (en, 2012) | 1981-02-27 |
| YU293381A (en) | 1985-04-30 |
| AU498511B2 (en) | 1979-03-15 |
| ZA756732B (en) | 1976-10-27 |
| DK146803B (da) | 1984-01-09 |
| FR2289203B1 (en, 2012) | 1978-11-10 |
| JPS5168561A (en, 2012) | 1976-06-14 |
| JPS59104397A (ja) | 1984-06-16 |
| DK482175A (da) | 1976-04-30 |
| YU37119B (en) | 1984-08-31 |
| US4025623A (en) | 1977-05-24 |
| BE834939A (fr) | 1976-04-28 |
| SU646913A3 (ru) | 1979-02-05 |
| CH618707A5 (en, 2012) | 1980-08-15 |
| DE2548087A1 (de) | 1976-05-06 |
| CA1046509A (en) | 1979-01-16 |
| ATA812975A (de) | 1977-04-15 |
| JPS6056720B2 (ja) | 1985-12-11 |
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