ES440240A1 - Un procedimiento para la obtencion de un preparado enzimati-co util para efectuar transformaciones quimicas. - Google Patents

Un procedimiento para la obtencion de un preparado enzimati-co util para efectuar transformaciones quimicas.

Info

Publication number
ES440240A1
ES440240A1 ES440240A ES440240A ES440240A1 ES 440240 A1 ES440240 A1 ES 440240A1 ES 440240 A ES440240 A ES 440240A ES 440240 A ES440240 A ES 440240A ES 440240 A1 ES440240 A1 ES 440240A1
Authority
ES
Spain
Prior art keywords
water
enzyme preparation
affinity
immiscible liquid
immiscible liquids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440240A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES440240A1 publication Critical patent/ES440240A1/es
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/06—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
    • B01J31/061—Chiral polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/06—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/096—Polyesters; Polyamides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un procedimiento para la obtención de un preparado enzimatico útil para efectuar transformaciones químicas que, opcionalmente, comprende un soporte polimérico y que contiene un enzima unido a grupos no polares suficientes para que, al poner en contacto el preparado en un medio acuoso con un líquido inerte no miscible con agua y resulte con ello separable del medio acuoso, cuyo procedimiento consiste en : a) modificar, en su caso, el soporte polimérico y/o el enzima para incorporar el grupo no polar, y cuando sean necesario, el grupo formador de puente: b) poner en contacto un compuesto de formula R-X, donde R es un grupo no-polar y X es un grupo funcional o un material polimérico que contiene por lo menos un grupo funcional (y que, opcionalmente puede ser modificado según la etapa (a)), con un enzima unido a un grupo Y donde Y es un grupo activo capaz de reaccionar con X, o un material polimérico que contiene por lo menos un grupo activo capaz de reaccionar con X.
ES440240A 1974-08-13 1975-08-13 Un procedimiento para la obtencion de un preparado enzimati-co util para efectuar transformaciones quimicas. Expired ES440240A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3555674 1974-08-13
GB1743475A GB1463513A (en) 1974-08-13 1975-04-26 Enzymes

Publications (1)

Publication Number Publication Date
ES440240A1 true ES440240A1 (es) 1978-06-01

Family

ID=26252681

Family Applications (1)

Application Number Title Priority Date Filing Date
ES440240A Expired ES440240A1 (es) 1974-08-13 1975-08-13 Un procedimiento para la obtencion de un preparado enzimati-co util para efectuar transformaciones quimicas.

Country Status (19)

Country Link
US (1) US4267273A (es)
JP (1) JPS5151582A (es)
AR (2) AR216891A1 (es)
AT (1) AT363889B (es)
AU (1) AU497573B2 (es)
BR (1) BR7505186A (es)
CA (1) CA1053595A (es)
CH (1) CH624431A5 (es)
DE (1) DE2535951A1 (es)
DK (1) DK143349C (es)
ES (1) ES440240A1 (es)
FI (1) FI752275A (es)
FR (1) FR2288748A1 (es)
GB (1) GB1463513A (es)
IE (1) IE41894B1 (es)
IL (1) IL47893A (es)
MX (1) MX2951E (es)
NL (1) NL7509667A (es)
SE (2) SE7509008L (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5548392A (en) 1978-02-17 1980-04-07 Toyo Jozo Co Ltd Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support
SE416314B (sv) * 1978-04-03 1980-12-15 Svenska Sockerfabriks Ab Enzymatiskt forfarande, varvid enzymet foreligger i ett losligt komplex med hydrofob bindning och en del som modifierar enzymetsproduktivitetskinetiska egenskaper samt det losliga komplexet
DE2839737A1 (de) * 1978-09-13 1980-03-20 Roehm Gmbh Verfahren zur enzymatischen umsetzung mittels traegergebundener enzyme
DE2937964C2 (de) * 1979-09-20 1982-11-11 Peter 3400 Göttingen Schilling Mittel zur Bekämpfung der Karies
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
US4632904A (en) * 1983-12-27 1986-12-30 Ciba Corning Diagnostics Corp. Immobilized enzyme composites having carriers derivatized with an organotitanate
US4795542A (en) * 1986-04-24 1989-01-03 St. Jude Medical, Inc. Electrochemical concentration detector device
DE3784592T2 (de) * 1986-08-07 1993-09-23 Minnesota Mining & Mfg Stabile, biologisch-aktive, fluorchemische emulsionen.
US4808530A (en) * 1986-09-05 1989-02-28 The Ohio State University Protein immobilization by adsorption of a hydrophobic amidine protein derivative to a hydrophobic surface
US4885250A (en) * 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
EP0353953A3 (en) * 1988-08-04 1990-11-22 Imperial Chemical Industries Plc Performing an enzyme-catalysed reaction
US5289855A (en) * 1988-10-14 1994-03-01 Elkay Manufacturing Co. Liquid container support and probe-type hygienic liquid dispensing system
US5295519A (en) * 1988-10-14 1994-03-22 Elkay Manufacturing Company Hygienic liquid dispensing system including feed tube or probe for opening and resealing coaxial cap
WO1990006996A1 (en) * 1988-12-19 1990-06-28 Sepracor, Inc. Method and apparatus for catalyst containment in multiphase membrane reactor systems
US5270193A (en) * 1989-10-27 1993-12-14 E. I. Dupont De Nemours And Company Immobilization of biomolecules on perfluorocarbon surfaces
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
US5288619A (en) * 1989-12-18 1994-02-22 Kraft General Foods, Inc. Enzymatic method for preparing transesterified oils
AU644199B2 (en) * 1990-08-10 1993-12-02 Holmwood Highgate (Aust) Pty Ltd Road tanker
US5182201A (en) * 1990-10-26 1993-01-26 Uop Lipase immobilization without covalent bonding on an amphiphilic support containing lipophilic alkyl chains
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
EP3132033B1 (en) 2014-04-17 2019-10-30 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
JP6803328B2 (ja) 2014-08-28 2021-01-06 シンセティック バイオロジクス，インコーポレイテッド 大腸菌ベースでのベータラクタマーゼ生産
JP6672277B2 (ja) 2014-10-08 2020-04-01 シンセティック・バイオロジクス・インコーポレイテッド ベータラクタマーゼ製剤およびその使用
WO2016105498A1 (en) 2014-12-23 2016-06-30 Synthetic Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
CN107530406B (zh) 2015-02-23 2021-10-22 合成生物制品有限公司 用于保护肠微生物群系的与抗生素一起使用的碳青霉烯酶
AU2016229976B2 (en) 2015-03-06 2021-11-11 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
WO2020088510A1 (zh) * 2018-10-30 2020-05-07 武汉武药制药有限公司 一种(r)-邻氯扁桃酸的制备方法和用于该制备方法的一种循环式生物酶催化反应系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706633A (en) * 1970-04-10 1972-12-19 Monsanto Co Preparation of water-insoluble enzyme derivatives
US3741871A (en) * 1972-01-04 1973-06-26 Monsanto Co Preparation of immobilized enzymes
GB1449808A (en) * 1972-11-21 1976-09-15 Beecham Group Ltd 6-aminopenicillanic acid preparation

Also Published As

Publication number Publication date
BR7505186A (pt) 1976-08-03
FI752275A (es) 1976-02-14
CH624431A5 (es) 1981-07-31
AU8394275A (en) 1977-02-17
GB1463513A (en) 1977-02-02
CA1053595A (en) 1979-05-01
AT363889B (de) 1981-09-10
NL7509667A (nl) 1976-02-17
SE8006247L (sv) 1980-09-08
DE2535951A1 (de) 1976-02-26
IE41894B1 (en) 1980-04-23
MX2951E (es) 1980-01-03
DK143349B (da) 1981-08-10
FR2288748B1 (es) 1979-05-25
ATA629375A (de) 1981-02-15
IL47893A0 (en) 1975-11-25
US4267273A (en) 1981-05-12
IE41894L (en) 1976-02-13
FR2288748A1 (fr) 1976-05-21
IL47893A (en) 1978-07-31
AU497573B2 (en) 1978-12-21
DK143349C (da) 1981-12-07
JPS5151582A (es) 1976-05-07
DK365275A (da) 1976-02-14
AR218089A1 (es) 1980-05-15
AR216891A1 (es) 1980-02-15
SE7509008L (sv) 1976-02-16

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