ES432220A1 - Phenylalkenoic acid derivatives - Google Patents

Phenylalkenoic acid derivatives

Info

Publication number
ES432220A1
ES432220A1 ES432220A ES432220A ES432220A1 ES 432220 A1 ES432220 A1 ES 432220A1 ES 432220 A ES432220 A ES 432220A ES 432220 A ES432220 A ES 432220A ES 432220 A1 ES432220 A1 ES 432220A1
Authority
ES
Spain
Prior art keywords
radical
general formula
acids
formula
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432220A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2205732A external-priority patent/DE2205732A1/en
Priority claimed from DE19722223562 external-priority patent/DE2223562A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES432220A1 publication Critical patent/ES432220A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/08Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of new derivatives of 3-butenoic and 2-butenoic acids of the general formula I **(See formula)** wherein the R1 radical means a branched or unbranched alcohol radical with 1 to 7 carbon atoms, a 5-, 6- or 7-membered cycloalkyl or cycloalkenyl radical, the piperidino radical or a phenyl radical, which may optionally be substituted by one or two halogen atoms, a nitro or cyano group, or an amino group optionally substituted by an aliphatic acyl radical with 1 to 4 carbon atoms, the radical R3 means a hydrogen atom, a halogen atom or, if R1 it has the meanings indicated above with the exception of that of an optionally substituted phenyl radical, it represents a nitro, amino or cyano group, provided that R3 does not mean any hydrogen atom when R1 represents an unsubstituted phenyl radical, and the radical B means the hydroxy group, an alkoxy radical with 1 to 4 carbon atoms or a radical of the general formula II, **(See formula)** where R4 and R5, which may be the same or different, represent hydrogen atoms, or, if R1 means an optionally substituted phenyl radical as defined above, they also represent alcohol radicals with 1 to 3 carbon atoms, in this case R4 may also be a hydroxyphenyl radical when R5 signifies a hydrogen atom and radical A signifies the bivalent radical (see formula) in which R2 represents a hydrogen atom or an alcohol radical with 1 to 2 carbon atoms, as well as, if B is the hydroxy group, its physiologically compatible salts with organic or inorganic bases and, in the case of that R1 contains a basic radical or R3 means a basic group, of its physiologically compatible salts with organic or inorganic acids, characterized in that for the preparation of the free acids of the general formula I, lactones of the formula are heated to 140 to 200ºC general IV **(See formula)** wherein R1 to R3 and B are as defined above, in the presence of salts of halohydric acids of tertiary organic bases; the final products are separated in a known manner and a mixture obtained is separated into the cis and trans isomers of these acids, and/or compounds obtained from the general formula I, in which B is the hydroxy group, is transformed if desired into Compounds of the general formula I, in which B represents an alkoxy group, and/or compounds of the general formula I, in which B means a halogen atom or an alkoxy group, is transformed with an amine of the general formula VIII **(See formula)** in the amides of the general formula I, and/or if desired acids of the general formula I are transformed with organic or inorganic bases in their salts, and the compounds of the general formula I, in which R1 contains a basic radical or R3 means basic radicals, they are transformed if desired into their salts by adding acid with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
ES432220A 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives Expired ES432220A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2205732A DE2205732A1 (en) 1972-02-08 1972-02-08 NEW 4- (4-BIPHENYLYL) -BUTIC ACID DERIVATIVES
DE19722223562 DE2223562A1 (en) 1972-05-15 1972-05-15 NEW BUTENIC ACIDS, THEIR SALT AND DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ES432220A1 true ES432220A1 (en) 1976-11-01

Family

ID=25762690

Family Applications (3)

Application Number Title Priority Date Filing Date
ES432219A Expired ES432219A1 (en) 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives
ES432218A Expired ES432218A1 (en) 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives
ES432220A Expired ES432220A1 (en) 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES432219A Expired ES432219A1 (en) 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives
ES432218A Expired ES432218A1 (en) 1972-02-08 1974-11-23 Phenylalkenoic acid derivatives

Country Status (13)

Country Link
JP (1) JPS4891032A (en)
AT (3) AT325025B (en)
BE (1) BE795159A (en)
BG (1) BG21391A3 (en)
CA (1) CA978967A (en)
DD (1) DD107898A5 (en)
ES (3) ES432219A1 (en)
GB (1) GB1413042A (en)
HU (1) HU165625B (en)
IL (1) IL41484A0 (en)
NL (1) NL7301631A (en)
SU (1) SU526285A3 (en)
ZA (1) ZA73851B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR68102B (en) * 1978-08-08 1981-10-30 Fujisawa Pharmaceutical Co

Also Published As

Publication number Publication date
ES432218A1 (en) 1976-11-01
DD107898A5 (en) 1974-08-20
HU165625B (en) 1974-09-28
BG21391A3 (en) 1976-05-20
NL7301631A (en) 1973-08-10
ATA311374A (en) 1975-03-15
ES432219A1 (en) 1976-11-01
ZA73851B (en) 1974-10-30
AT326640B (en) 1975-12-29
AT325026B (en) 1975-09-25
JPS4891032A (en) 1973-11-27
BE795159A (en) 1973-08-08
GB1413042A (en) 1975-11-05
AT325025B (en) 1975-09-25
IL41484A0 (en) 1973-04-30
SU526285A3 (en) 1976-08-25
CA978967A (en) 1975-12-02

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