ES415414A1 - Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding) - Google Patents

Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES415414A1
ES415414A1 ES415414A ES415414A ES415414A1 ES 415414 A1 ES415414 A1 ES 415414A1 ES 415414 A ES415414 A ES 415414A ES 415414 A ES415414 A ES 415414A ES 415414 A1 ES415414 A1 ES 415414A1
Authority
ES
Spain
Prior art keywords
formula
group
benzamides
general formula
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES415414A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7219804A external-priority patent/FR2193577A1/en
Priority claimed from FR7219803A external-priority patent/FR2187310A1/en
Priority claimed from FR7221307A external-priority patent/FR2187323A1/en
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of ES415414A1 publication Critical patent/ES415414A1/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparation method of 2-alkoxy-benzamides substituted in positions 4 and 5, which respond to the following general formula (V): **(See formula)** of its addition salts with pharmaceutically acceptable mineral or organic acids and of its quaternary ammonium salts, obtained by reacting these benzamides with an aliphatic or aromatic alcoholic agent, formula in which: R1 can be a hydrogen atom or a methyl group; Z can be an alcohol or alkenyl radical of 1 to 4 carbon atoms; X can be a hydrogen atom, a nitro or acylamino group; Y can be a hydrogen atom, a halogen atom or a SO2R2 group where R2 is an amino or monoalkoxylamino or dialcoylamino or alcohol group with 1 to 5 carbon atoms or halogenoalcohyl; n can be an integer less than or equal to 3; A can be either a radical of the form (see formula), being R3 and R4 the same or different alcohol groups of low molecular weights and being able to form with nitrogen a heterocycle, or a heterocyclic radical of formula (VI): **(See formula)** in which: R can be an alcohol or alkenyl radical of 1 to 4 carbon atoms and m can be an integer less than or equal to 4, characterized by the reaction of 2-alkoxy-benzoic acid substituted at positions 4 and 5 of general formula (I): **(See formula)** in which Z, X and Y have the aforementioned meanings, with a haloformic acid ester of general formula (II) MCO2B in which M is a halogen atom and B an alcoholic group reacting the formed alcoholic carbonic anhydride (III) with a diamine of general formula (IV) **(See formula)** in which R1, n and A have the aforementioned meanings, to form the desired benzamide (V). (Machine-translation by Google Translate, not legally binding)
ES415414A 1972-06-01 1973-05-30 Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding) Expired ES415414A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7219804A FR2193577A1 (en) 1972-06-01 1972-06-01 N-(substd alkyl)-2-alk(enyl)oxybenzamides - antiemetics digestion-regulators and psychotropics
FR7219803A FR2187310A1 (en) 1972-06-01 1972-06-01 N-(substd alkyl)-2-alk(enyl)oxybenzamides - antiemetics digestion-regulators and psychotropics
FR7221307A FR2187323A1 (en) 1972-06-12 1972-06-12 N-(substd alkyl)-2-alk(enyl)oxybenzamides - antiemetics digestion-regulators and psychotropics

Publications (1)

Publication Number Publication Date
ES415414A1 true ES415414A1 (en) 1976-02-01

Family

ID=27249876

Family Applications (1)

Application Number Title Priority Date Filing Date
ES415414A Expired ES415414A1 (en) 1972-06-01 1973-05-30 Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES415414A1 (en)
RO (1) RO69250A (en)

Also Published As

Publication number Publication date
RO69250A (en) 1980-08-15

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