ES415454A1 - Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding) - Google Patents

Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES415454A1
ES415454A1 ES415454A ES415454A ES415454A1 ES 415454 A1 ES415454 A1 ES 415454A1 ES 415454 A ES415454 A ES 415454A ES 415454 A ES415454 A ES 415454A ES 415454 A1 ES415454 A1 ES 415454A1
Authority
ES
Spain
Prior art keywords
formula
alcohol
carbon atoms
group
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES415454A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Original Assignee
Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes Scientifiques et Industrielles de lIle de France SA filed Critical Societe dEtudes Scientifiques et Industrielles de lIle de France SA
Publication of ES415454A1 publication Critical patent/ES415454A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Preparation method of 2-alkoxybenzamides substituted portions 4 and 5, which correspond to the following general formula (V): **(See formula)** of its addition salts with pharmaceutically acceptable organic or mineral acids, and its quaternary ammonium salts obtained by reacting these benzamides with an aliphatic or aromatic alcoholizing agent, formula in which: R1 can be a hydrogen atom or a methyl group; B can be an alcohol or alkenyl radical of 1 to 4 carbon atoms; X can be a hydrogen atom or a nitro group, Y can be a hydrogen atom or a SO2R2 group, where R2 can be an amino, monoalkoxylamino, dialkoxylamino or alcohol group with 1 to 5 carbon atoms, or halogenoalcohyl; n can be an integer less than or equal to 3, A can be, or a radical of the form (see formula), R3 and R4 being low molecular weight alcohol groups, identical or different and that can form with nitrogen a heterocycle, or a heterocyclic radical of formula (VI) **(See formula)** wherein: R can be an alcohol or alkenyl radical of 1 to 4 carbon atoms; m can be an integer less than or equal to 4; m cannot take the value 1 other than when R2 is a monoalkoxy, dialkoxylamino, halogenoalcoyl or alcohol group having at least three carbon atoms; characterized by reacting a diamine of the general formula (I) **(See formula)** in which R1, n and A have the aforementioned meanings, with carbon sulfide, and for treating in basic medium the dithiocarbamic acid (II) formed with a substance (P) capable of reacting with sulfur to give a volatile or insoluble compound, and by condensing the isothiocyanate (III) obtained with a 2-alkoxy-benzoic acid substituted at positions 4 and 5 (IV). (Machine-translation by Google Translate, not legally binding)
ES415454A 1973-04-05 1973-06-01 Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding) Expired ES415454A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7312392A FR2224448A1 (en) 1973-04-05 1973-04-05 N-(substd alkyl)-2-alk(enyl)oxybenzamides - antiemetics digestion-regulators and psychotropics

Publications (1)

Publication Number Publication Date
ES415454A1 true ES415454A1 (en) 1976-02-16

Family

ID=9117504

Family Applications (1)

Application Number Title Priority Date Filing Date
ES415454A Expired ES415454A1 (en) 1973-04-05 1973-06-01 Method of preparation of 2-alcoxy-benzamides replaced in positions 4 and 5. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
KR (1) KR780000266B1 (en)
ES (1) ES415454A1 (en)
FR (1) FR2224448A1 (en)
HU (2) HU168989B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2305176A1 (en) * 1975-03-28 1976-10-22 Ile De France NEW DRUG BASED ON N- (DIETHYLAMINOETHYL) 2-METHOXY-5-METHYL-SULFONYL BENZAMIDE

Also Published As

Publication number Publication date
FR2224448A1 (en) 1974-10-31
HU169275B (en) 1976-10-28
FR2224448B1 (en) 1977-12-30
KR780000266B1 (en) 1978-07-24
HU168989B (en) 1976-08-28

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