ES390365A1 - Sulphamoylpyrimidines containing an asymmetric carbon atom and having a blood sugar lowering activity - Google Patents
Sulphamoylpyrimidines containing an asymmetric carbon atom and having a blood sugar lowering activityInfo
- Publication number
- ES390365A1 ES390365A1 ES390365A ES390365A ES390365A1 ES 390365 A1 ES390365 A1 ES 390365A1 ES 390365 A ES390365 A ES 390365A ES 390365 A ES390365 A ES 390365A ES 390365 A1 ES390365 A1 ES 390365A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- see
- groups
- general formula
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedure for the preparation of new sulfamoylpyrimidines of the general formula ** (See formula) ** in which (see graph) means an asymmetric carbon atom, X and Y are the same or different and each in itself means a direct bond or a methylene group, R1 and R2 mean hydrogen or halogen atoms, alcohol groups with 1-6 carbon atoms or alkoxy groups with 1-4 carbon atoms, R3 and R4 are different and signify hydrogen atoms, straight or branched chain (1-4 carbon atoms) alcohol groups, carboxyl or alkoxycarbonyl groups (with 1- 4 carbon atoms), R5 and R7 are the same or different and mean hydrogen atoms or lower alcohol groups with 1-4 carbon atoms, R6 means a straight or branched chain alcohol group with 1-6 carbon atoms and W means a direct CC bond or an oxygen or sulfur atom, as well as its salts with physiologically compatible bases, characterized in that an optionally optically active sulfohalogenide of the general formula is reacted with guanidine or a salt thereof ** (See formula) ** in which C (see image), X, Y, R1, R2, R3, R4, R5 and R7 mean the same as above and Q means a halogen atom, preferably chlorine, and the optionally active guanidinosulfonyl compound is condensed with a ring closure resulting from the general formula ** (See formula) ** with a substituted malonodialdehyde of the general formula ** (See formula) ** where W and R6 mean the same as above, where the aldehyde groups may also be functionally modified. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2021962A DE2021962C3 (en) | 1970-04-28 | 1970-04-28 | Blood sugar lowering sulfamoylpyrimidines with an asymmetric carbon atom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES390365A1 true ES390365A1 (en) | 1974-06-01 |
Family
ID=5770301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES390365A Expired ES390365A1 (en) | 1970-04-28 | 1971-04-20 | Sulphamoylpyrimidines containing an asymmetric carbon atom and having a blood sugar lowering activity |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5516143B1 (en) |
| AT (3) | AT307421B (en) |
| BE (1) | BE766409A (en) |
| CH (3) | CH568983A5 (en) |
| DE (1) | DE2021962C3 (en) |
| DK (1) | DK125324B (en) |
| ES (1) | ES390365A1 (en) |
| FR (1) | FR2092102B1 (en) |
| GB (1) | GB1353511A (en) |
| IL (1) | IL36704A (en) |
| NL (1) | NL170853C (en) |
| NO (1) | NO131835C (en) |
| SE (1) | SE378419B (en) |
| SU (2) | SU415878A3 (en) |
| YU (1) | YU34412B (en) |
| ZA (1) | ZA712142B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789712R (en) * | 1970-04-28 | 1973-04-05 | Schering Ag | SULFAMOYLPYRIMIDINES, ASYMMETRICAL CARBON ATOM, THEIR PREPARATION PROCESS AND THEIR |
| JPS6088929U (en) * | 1983-11-28 | 1985-06-18 | 五十嵐 五大 | health retainer |
| JPS62128478U (en) * | 1986-02-05 | 1987-08-14 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670188A1 (en) * | 1967-02-01 | 1971-03-25 | Boehringer Mannheim Gmbh | Process for the production of new antidiabetic sulfonamides |
| DE1695855C3 (en) * | 1967-12-30 | 1979-07-12 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 4- (5-Isobutyl-2-pyrimidinyl) -sulfonamidophenylacetic acid- (2-methoxy-5-chloroanilide) and its salts with physiologically compatible bases |
-
1970
- 1970-04-28 DE DE2021962A patent/DE2021962C3/en not_active Expired
-
1971
- 1971-03-15 CH CH245174A patent/CH568983A5/xx not_active IP Right Cessation
- 1971-03-15 CH CH245274A patent/CH556846A/en not_active IP Right Cessation
- 1971-03-15 CH CH370971A patent/CH550181A/en not_active IP Right Cessation
- 1971-04-01 YU YU809/71A patent/YU34412B/en unknown
- 1971-04-02 DK DK158671AA patent/DK125324B/en unknown
- 1971-04-02 ZA ZA712142A patent/ZA712142B/en unknown
- 1971-04-20 AT AT335971A patent/AT307421B/en not_active IP Right Cessation
- 1971-04-20 NO NO1456/71A patent/NO131835C/no unknown
- 1971-04-20 AT AT521372A patent/AT307431B/en not_active IP Right Cessation
- 1971-04-20 ES ES390365A patent/ES390365A1/en not_active Expired
- 1971-04-20 AT AT521272A patent/AT307430B/en not_active IP Right Cessation
- 1971-04-23 SE SE7105321A patent/SE378419B/xx unknown
- 1971-04-25 IL IL36704A patent/IL36704A/en unknown
- 1971-04-26 GB GB1129571*[A patent/GB1353511A/en not_active Expired
- 1971-04-27 FR FR7114939A patent/FR2092102B1/fr not_active Expired
- 1971-04-28 SU SU1692740A patent/SU415878A3/ru active
- 1971-04-28 JP JP2852471A patent/JPS5516143B1/ja active Pending
- 1971-04-28 BE BE766409A patent/BE766409A/en unknown
- 1971-04-28 NL NLAANVRAGE7105835,A patent/NL170853C/en not_active IP Right Cessation
- 1971-04-28 SU SU1692741A patent/SU415879A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| AT307421B (en) | 1973-05-25 |
| ZA712142B (en) | 1971-12-29 |
| NL170853C (en) | 1983-01-03 |
| SE378419B (en) | 1975-09-01 |
| CH550181A (en) | 1974-06-14 |
| FR2092102A1 (en) | 1972-01-21 |
| IL36704A (en) | 1974-09-10 |
| DK125324B (en) | 1973-02-05 |
| NL7105835A (en) | 1971-11-01 |
| IL36704A0 (en) | 1971-06-23 |
| BE766409A (en) | 1971-10-28 |
| SU415879A3 (en) | 1974-02-15 |
| JPS5516143B1 (en) | 1980-04-30 |
| AT307431B (en) | 1973-05-25 |
| GB1353511A (en) | 1974-05-22 |
| YU80971A (en) | 1978-12-31 |
| DE2021962B2 (en) | 1981-04-16 |
| CH556846A (en) | 1974-12-13 |
| NL170853B (en) | 1982-08-02 |
| SU389661A3 (en) | 1973-07-05 |
| YU34412B (en) | 1979-07-10 |
| FR2092102B1 (en) | 1974-08-30 |
| AT307430B (en) | 1973-05-25 |
| DE2021962A1 (en) | 1971-11-18 |
| SU439978A3 (en) | 1974-08-15 |
| SU415878A3 (en) | 1974-02-15 |
| CH568983A5 (en) | 1975-11-14 |
| NO131835B (en) | 1975-05-05 |
| DE2021962C3 (en) | 1981-12-24 |
| NO131835C (en) | 1975-08-13 |
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