SE317057B - - Google Patents

Info

Publication number
SE317057B
SE317057B SE5414/65A SE541465A SE317057B SE 317057 B SE317057 B SE 317057B SE 5414/65 A SE5414/65 A SE 5414/65A SE 541465 A SE541465 A SE 541465A SE 317057 B SE317057 B SE 317057B
Authority
SE
Sweden
Prior art keywords
formula
salt
prepared
reaction
compound
Prior art date
Application number
SE5414/65A
Inventor
J Bream
C Picard
T White
Original Assignee
Wander Ag Dr A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander Ag Dr A filed Critical Wander Ag Dr A
Publication of SE317057B publication Critical patent/SE317057B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel guanidine derivatives of formula <FORM:1096348/C2/1> and acid addition salts thereof, wherein A is C2 or C3 alkylene and R1 and R2 are H, halogen, methyl, ethyl, methoxy or ethoxy, are prepared either by reaction of a compound of formula <FORM:1096348/C2/2> with cyanamide or an S-alkylisothiourea or its salt, or by reduction of a compound of formula <FORM:1096348/C2/3> wherein A1 is alkylylidene or alkenylylidene corresponding to A. Compounds of the last formula above are prepared by reaction of a salt of amino-guanidine and an aldehyde of formula <FORM:1096348/C2/4> o-Tolylpropionaldehyde is prepared by oxidation of the corresponding alcohol. Pharmaceutical compositions in tablet form comprise an above novel guanidine or a salt thereof and a carrier. Reference has been directed by the Comptroller to Specification 1,064,176.
SE5414/65A 1964-05-05 1965-04-26 SE317057B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH585464A CH448057A (en) 1964-05-05 1964-05-05 Process for the preparation of phenylalkylaminoguanidines

Publications (1)

Publication Number Publication Date
SE317057B true SE317057B (en) 1969-11-10

Family

ID=4300408

Family Applications (2)

Application Number Title Priority Date Filing Date
SE5414/65A SE317057B (en) 1964-05-05 1965-04-26
SE6816331A SE371640B (en) 1964-05-05 1965-04-26

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE6816331A SE371640B (en) 1964-05-05 1965-04-26

Country Status (15)

Country Link
JP (1) JPS4842627B1 (en)
AT (3) AT255433B (en)
BE (1) BE663481A (en)
BR (1) BR6569419D0 (en)
CH (3) CH491873A (en)
CS (1) CS151461B2 (en)
DE (1) DE1518222A1 (en)
DK (2) DK107288C (en)
ES (1) ES312384A1 (en)
FI (1) FI42316B (en)
FR (1) FR4399M (en)
GB (1) GB1096348A (en)
IL (1) IL23443A (en)
NL (1) NL6505684A (en)
SE (2) SE317057B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR200F (en) * 1965-11-15
US3541218A (en) * 1969-06-18 1970-11-17 Lilly Co Eli Omicron-fluorobenzylaminoguanidine for diabetes
JPS5051717U (en) * 1973-09-06 1975-05-19
JPS5391735U (en) * 1976-12-27 1978-07-27
JPS54121027U (en) * 1978-02-13 1979-08-24
DK153787C (en) * 1979-06-01 1989-01-16 Wellcome Found METHOD OF ANALOGUE FOR THE PREPARATION OF SUBSTITUTED 3,5-DIAMINO-6-PHENYL-1,2,4-TRIAZINES AND ALFA-CYANOBENZYLIDEEN-AMINOGUANIDE COMPOUNDS FOR USE AS INTERMEDIATES
EP0021120B1 (en) * 1979-06-01 1983-04-06 The Wellcome Foundation Limited 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
FR2549049B1 (en) * 1983-07-13 1986-06-20 Chauvin Blache Lab NEW AMIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives
EP0325936A3 (en) * 1988-01-16 1990-01-17 Ono Pharmaceutical Co., Ltd. Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients
WO1997036580A1 (en) * 1996-03-29 1997-10-09 3-Dimensional Pharmaceuticals, Inc. Amidinohydrazones as protease inhibitors
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
AU2001277242A1 (en) 2000-08-04 2002-02-18 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors

Also Published As

Publication number Publication date
FI42316B (en) 1970-03-31
IL23443A (en) 1968-09-26
GB1096348A (en) 1967-12-29
AT255434B (en) 1967-07-10
CS151461B2 (en) 1973-10-19
BE663481A (en)
ES312384A1 (en) 1966-03-01
DK111887B (en) 1968-10-21
SE371640B (en) 1974-11-25
AT255433B (en) 1967-07-10
DK107288C (en) 1967-05-16
CH448057A (en) 1967-12-15
CH491873A (en) 1970-06-15
CH511216A (en) 1971-08-15
FR4399M (en) 1966-09-05
JPS4842627B1 (en) 1973-12-13
DE1518222A1 (en) 1969-06-12
BR6569419D0 (en) 1973-08-02
AT255432B (en) 1967-07-10
NL6505684A (en) 1965-11-08

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