ES385473A1 - Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES385473A1
ES385473A1 ES385473A ES385473A ES385473A1 ES 385473 A1 ES385473 A1 ES 385473A1 ES 385473 A ES385473 A ES 385473A ES 385473 A ES385473 A ES 385473A ES 385473 A1 ES385473 A1 ES 385473A1
Authority
ES
Spain
Prior art keywords
phenyl
chlorine
atom
hydroxy
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES385473A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES385473A1 publication Critical patent/ES385473A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for the preparation of new basically substituted tertiary butanoles of the formula: **(See formula)** where Hal means a chlorine or bromine atom; R1 signifies a hydrogen, chlorine or bromine atom; R2 and R3, which may be the same or different, mean straight or branched chain alcohol radicals, alkenyl, dialcoylaminoalcohilo, cycloalcohilo, phenyl, aralcohilo or adamantyl, one of the R2 or R3 radicals also being able to represent a hydrogen atom or together with the Nitrogen atom means a pyrrolidine, piperidine, piperazine, morpholine, hexamethyleneimine or camfidine ring optionally substituted by hydroxy, alkoxy, phenyl or lower alcohol groups; and R4 signifies a straight or branched chain alcohol radical, cycloalkoxy, cycloalkenyl, norbonyl, phenyl, aralkoxy, naphthyl, pyridyl or thienyl, a cyclohexyl radical substituted by hydroxy or lower alcohol groups or a phenyl radical substituted by hydroxy, alcohol, alkoxy groups., alcoholylthio, trifluoromsty, phenyl, phenoxy, by fluorine, chlorine or bromine atoms; as well as its physiologically compatible acid addition salts, characterized in that a compound of the general formula: **(See formula)** wherein Hal, R1, R2 except for hydrogen and R1 except for the pyridyl radical, are as initially defined, with a compound of the general formula R3 - Y (III) wherein R3 is as defined above and Y represents a chlorine, bromine or iodine atom and if desired a compound obtained of the general formula I is transformed into a salt, according to usual methods, with an organic or inorganic acid at physiologically compatible inorganic. (Machine-translation by Google Translate, not legally binding)
ES385473A 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding) Expired ES385473A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702042750 DE2042750A1 (en) 1970-08-28 1970-08-28 Basic substd tert butanols; transquilising - anti emetic ulcer inhibitory

Publications (1)

Publication Number Publication Date
ES385473A1 true ES385473A1 (en) 1973-05-01

Family

ID=5780991

Family Applications (3)

Application Number Title Priority Date Filing Date
ES385472A Expired ES385472A1 (en) 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)
ES385473A Expired ES385473A1 (en) 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)
ES385471A Expired ES385471A1 (en) 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES385472A Expired ES385472A1 (en) 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES385471A Expired ES385471A1 (en) 1970-08-28 1970-11-12 Procedure for the preparation of new tertiary butanols basically replaced. (Machine-translation by Google Translate, not legally binding)

Country Status (9)

Country Link
KR (2) KR780000213B1 (en)
AT (3) AT310723B (en)
BG (2) BG17748A3 (en)
CS (2) CS168544B2 (en)
DE (1) DE2042750A1 (en)
ES (3) ES385472A1 (en)
PL (1) PL84543B1 (en)
RO (2) RO59184A (en)
SU (2) SU421179A3 (en)

Also Published As

Publication number Publication date
CS168544B2 (en) 1976-06-29
BG17748A3 (en) 1973-12-25
RO59184A (en) 1976-02-15
AT308073B (en) 1973-06-25
ES385472A1 (en) 1973-05-01
PL84543B1 (en) 1976-04-30
BG17747A3 (en) 1973-12-25
DE2042750A1 (en) 1972-03-02
CS168543B2 (en) 1976-06-29
SU421179A3 (en) 1974-03-25
KR780000230B1 (en) 1978-07-01
AT310723B (en) 1973-10-10
RO58297A (en) 1975-07-15
AT308074B (en) 1973-06-25
KR780000213B1 (en) 1978-06-12
SU420170A3 (en) 1974-03-15
ES385471A1 (en) 1973-05-01

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