ES382680A1 - Un metodo de producir antibiotico b-5050. - Google Patents
Un metodo de producir antibiotico b-5050.Info
- Publication number
- ES382680A1 ES382680A1 ES382680A ES382680A ES382680A1 ES 382680 A1 ES382680 A1 ES 382680A1 ES 382680 A ES382680 A ES 382680A ES 382680 A ES382680 A ES 382680A ES 382680 A1 ES382680 A1 ES 382680A1
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- antibiotic
- components
- polar
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 6
- 239000002904 solvent Substances 0.000 abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 2
- 239000012454 non-polar solvent Substances 0.000 abstract 2
- 239000002798 polar solvent Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 229930188120 Carbomycin Natural products 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000187391 Streptomyces hygroscopicus Species 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- FQVHOULQCKDUCY-OGHXVOSASA-N [(2s,3s,4r,6s)-6-[(2r,3s,4r,5r,6s)-6-[[(1s,3r,7r,8s,9s,10r,12r,14e,16s)-7-acetyloxy-8-methoxy-3,12-dimethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimeth Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@H]1[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]([C@@H]1OC)OC(C)=O)[C@H]1C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O1 FQVHOULQCKDUCY-OGHXVOSASA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 229950005779 carbomycin Drugs 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- JYVHOGDBFNJNMR-UHFFFAOYSA-N hexane;hydrate Chemical compound O.CCCCCC JYVHOGDBFNJNMR-UHFFFAOYSA-N 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 238000004810 partition chromatography Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6408069 | 1969-08-13 | ||
| JP5300670A JPS4948518B1 (enrdf_load_stackoverflow) | 1970-06-17 | 1970-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES382680A1 true ES382680A1 (es) | 1972-11-16 |
Family
ID=26393690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES382680A Expired ES382680A1 (es) | 1969-08-13 | 1970-08-12 | Un metodo de producir antibiotico b-5050. |
Country Status (16)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109652350B (zh) * | 2019-03-01 | 2022-01-28 | 中国农业科学院农业资源与农业区划研究所 | 一株泰乐菌素降解菌及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3076746A (en) * | 1959-05-24 | 1963-02-05 | Sankyo Co | New antibiotics azalomycin b and f and a process for the production thereof |
| US3142671A (en) * | 1962-05-31 | 1964-07-28 | Banyu Pharmaceutical Company L | Glebomycin and salts thereof |
| US3271253A (en) * | 1964-11-19 | 1966-09-06 | Bristol Myers Co | Antibiotic ossamycin and method of preparing same |
| JPH1024864A (ja) * | 1996-07-11 | 1998-01-27 | Mitsubishi Agricult Mach Co Ltd | 作業車輛のカバー装置 |
-
0
- BE BE754819D patent/BE754819A/xx not_active IP Right Cessation
-
1970
- 1970-08-07 FI FI218170A patent/FI46261C/fi active
- 1970-08-11 CS CS557370A patent/CS181204B2/cs unknown
- 1970-08-11 FR FR7029556A patent/FR2068492B1/fr not_active Expired
- 1970-08-12 ES ES382680A patent/ES382680A1/es not_active Expired
- 1970-08-12 YU YU206170A patent/YU34907B/xx unknown
- 1970-08-12 DE DE19702039990 patent/DE2039990C2/de not_active Expired
- 1970-08-12 GB GB3878270A patent/GB1273643A/en not_active Expired
- 1970-08-12 DK DK413670A patent/DK124557B/da not_active IP Right Cessation
- 1970-08-12 SE SE1103270A patent/SE362263B/xx unknown
- 1970-08-12 NO NO308970A patent/NO130362B/no unknown
- 1970-08-13 CH CH1214770A patent/CH565861A5/xx not_active IP Right Cessation
- 1970-08-13 CA CA090669A patent/CA928237A/en not_active Expired
- 1970-08-13 AT AT738170A patent/AT302526B/de not_active IP Right Cessation
- 1970-08-13 NL NL7011997A patent/NL154782B/xx not_active IP Right Cessation
-
1975
- 1975-12-30 MY MY7500012A patent/MY7500012A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1273643A (en) | 1972-05-10 |
| NL7011997A (enrdf_load_stackoverflow) | 1971-02-16 |
| SE362263B (enrdf_load_stackoverflow) | 1973-12-03 |
| CS181204B2 (en) | 1978-03-31 |
| BE754819A (fr) | 1971-01-18 |
| MY7500012A (en) | 1975-12-31 |
| CA928237A (en) | 1973-06-12 |
| NO130362B (enrdf_load_stackoverflow) | 1974-08-19 |
| FR2068492A1 (enrdf_load_stackoverflow) | 1971-08-27 |
| DE2039990A1 (de) | 1971-02-18 |
| YU34907B (en) | 1980-04-30 |
| DE2039990C2 (de) | 1981-10-29 |
| FI46261C (fi) | 1973-02-12 |
| AT302526B (de) | 1972-10-25 |
| FR2068492B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| DK124557B (da) | 1972-10-30 |
| NL154782B (nl) | 1977-10-17 |
| YU206170A (en) | 1979-10-31 |
| CH565861A5 (enrdf_load_stackoverflow) | 1975-08-29 |
| FI46261B (enrdf_load_stackoverflow) | 1972-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Martin et al. | Studies on the biosynthesis of the erythromycins. II. Isolation and structure of a biosynthetic intermediate, 6-deoxyerythronolide B | |
| Miller et al. | Isolation of a cyclitol antibiotic: 2, 3, 4, 5‐tetrahydroxycyclohexanemethanol | |
| Inouye et al. | Studies on monoterpene glucosides. VII. Iridoid glucosides of Paederia scandens | |
| Carter et al. | Streptothricin. I. Preparation, Properties and Hydrolysis Products1 | |
| Kuehl Jr et al. | Isolation and some chemical properties of grisein | |
| KR850000529A (ko) | 안트라사이클린 유도체의 제조방법 | |
| DE2303418A1 (de) | Antibiotisch wirksame substanzen sowie verfahren zum isolieren und reinigen biologisch aktiver substanzen | |
| ES382680A1 (es) | Un metodo de producir antibiotico b-5050. | |
| KR930000164B1 (ko) | 프리마이신 성분 및 항생물질 복합체의 분리방법 | |
| Lanigan et al. | Metabolism of pyrrolizidine alkaloids in the ovine rumen. I. Formation of 7-α-hydroxy-1-α-methyl-8-α pyrrolizidine from heliotrine and lasiocarpine | |
| Chen et al. | Separation and Purification of Macrolides Using the Ito Multi-Layered Horizontal Coil Planet Centrifuge | |
| VISZ | II*. High Pressure–High Temperature Hydrogenation Studies | |
| Jones et al. | The structure of frankincense gum | |
| Reddy et al. | Studies on dhava tannins. I. The isolation and constitution of a gallotannin from dhava (Anogeissus latifolia) | |
| Martin et al. | Isolation, purification and properties of the hexaene macrolides candihexin I and candihexin II | |
| WATANABE et al. | 4-O-Acetyl Mycarose A New O-Acetyl Sugar Obtained from Leucomycin Minor Components | |
| Barker et al. | Structure of an acidic polysaccharide elaborated by Aerobacter aerogenes | |
| Vining et al. | Separation of endomycins A and B, and their identification as members of the polyene groups of antifungal antibiotics | |
| Hart et al. | Triterpenoids of Achras sapota (Sapotaceae) | |
| Cerezo | The carrageenans of gigartina skottsbergii s. et g.: Part III. methylation analysis of the fraction precipitated with 0.3-0.4 m potassium chloride | |
| KR940004838B1 (ko) | 녹차 플라보노이드의 추출방법 | |
| Okano et al. | Picrasinoside-A, a novel quassinoid glucoside from Picrasma ailanthoides Planchon | |
| Vondrová et al. | 16α-hydroxylation of progesterone by a strain of Actinomyces globosus | |
| Capasso et al. | Sterols, fatty acids and free amino acids from two Helvella species | |
| Majer | Macrolide antibiotics |