ES376067A1 - Un procedimiento para la preparacion de acidos 5-ciclohexil - 1 - indacarboxilicos. - Google Patents
Un procedimiento para la preparacion de acidos 5-ciclohexil - 1 - indacarboxilicos.Info
- Publication number
- ES376067A1 ES376067A1 ES376067A ES376067A ES376067A1 ES 376067 A1 ES376067 A1 ES 376067A1 ES 376067 A ES376067 A ES 376067A ES 376067 A ES376067 A ES 376067A ES 376067 A1 ES376067 A1 ES 376067A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- lower alkyl
- compound
- see formula
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- JBQMFBWTKWOSQX-UHFFFAOYSA-N 2,3-dihydro-1h-indene-1-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)CCC2=C1 JBQMFBWTKWOSQX-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000004715 keto acids Chemical class 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- BKEWDCUQDVDPHC-UHFFFAOYSA-N 5-cyclohexyl-2,3-dihydro-1h-indene-1-carboxylic acid Chemical class C=1C=C2C(C(=O)O)CCC2=CC=1C1CCCCC1 BKEWDCUQDVDPHC-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- -1 cyano, nitro, amino Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/55—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79572669A | 1969-01-31 | 1969-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES376067A1 true ES376067A1 (es) | 1972-05-16 |
Family
ID=25166286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES376067A Expired ES376067A1 (es) | 1969-01-31 | 1970-01-30 | Un procedimiento para la preparacion de acidos 5-ciclohexil - 1 - indacarboxilicos. |
Country Status (11)
| Country | Link |
|---|---|
| JP (2) | JPS4925662B1 (zh:) |
| BE (1) | BE745177A (zh:) |
| CH (2) | CH544055A (zh:) |
| DE (1) | DE2004038C3 (zh:) |
| DK (1) | DK130582B (zh:) |
| ES (1) | ES376067A1 (zh:) |
| FR (1) | FR2034514B1 (zh:) |
| GB (1) | GB1291644A (zh:) |
| NL (1) | NL165930C (zh:) |
| SE (1) | SE345995B (zh:) |
| YU (1) | YU34270B (zh:) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5530487U (zh:) * | 1978-08-18 | 1980-02-27 | ||
| JPS57156434A (en) * | 1981-03-19 | 1982-09-27 | Takeda Chem Ind Ltd | Zinc indanecarboxylate |
| JPS63143813U (zh:) * | 1987-03-13 | 1988-09-21 | ||
| ES2359916T3 (es) * | 2003-04-15 | 2011-05-30 | Aquinox Pharmaceuticals Inc. | Derivados de indeno como agentes farmacéuticos. |
| RU2015143675A (ru) | 2013-03-14 | 2017-04-27 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Ship1 модуляторы и относящиеся к ним способы |
| BR112015023009A2 (pt) | 2013-03-14 | 2017-08-22 | Aquinox Pharmaceuticals Inc | Moduladores de ship1 e métodos relacionados ao mesmo |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| AU2017209430A1 (en) | 2016-01-20 | 2018-07-12 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2886589A (en) * | 1957-08-05 | 1959-05-12 | Merck & Co Inc | 8-methyl-5-oxyphenyl hexahydroindan compounds |
| JPS5121981B1 (zh:) * | 1967-09-11 | 1976-07-06 |
-
1970
- 1970-01-28 SE SE1040/70A patent/SE345995B/xx unknown
- 1970-01-29 YU YU211/70A patent/YU34270B/xx unknown
- 1970-01-29 BE BE745177D patent/BE745177A/xx not_active IP Right Cessation
- 1970-01-29 DE DE2004038A patent/DE2004038C3/de not_active Expired
- 1970-01-29 DK DK42170AA patent/DK130582B/da unknown
- 1970-01-29 FR FR707003190A patent/FR2034514B1/fr not_active Expired
- 1970-01-30 NL NL7001380.A patent/NL165930C/xx not_active IP Right Cessation
- 1970-01-30 GB GB4535/70A patent/GB1291644A/en not_active Expired
- 1970-01-30 ES ES376067A patent/ES376067A1/es not_active Expired
- 1970-01-30 CH CH135070A patent/CH544055A/de not_active IP Right Cessation
- 1970-01-30 CH CH934073A patent/CH565132A5/xx not_active IP Right Cessation
- 1970-01-31 JP JP45008175A patent/JPS4925662B1/ja active Pending
-
1974
- 1974-01-14 JP JP49006668A patent/JPS5136271B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2004038C3 (de) | 1982-03-25 |
| NL165930C (nl) | 1981-06-15 |
| YU21170A (en) | 1978-10-31 |
| NL7001380A (zh:) | 1970-08-04 |
| DK130582C (zh:) | 1975-08-18 |
| JPS4925662B1 (zh:) | 1974-07-02 |
| CH544055A (de) | 1973-11-15 |
| BE745177A (fr) | 1970-07-29 |
| DK130582B (da) | 1975-03-10 |
| NL165930B (nl) | 1981-01-15 |
| JPS5136271B1 (zh:) | 1976-10-07 |
| DE2004038A1 (de) | 1970-08-06 |
| CH565132A5 (zh:) | 1975-08-15 |
| FR2034514A1 (zh:) | 1970-12-11 |
| GB1291644A (en) | 1972-10-04 |
| YU34270B (en) | 1979-04-30 |
| FR2034514B1 (zh:) | 1973-07-13 |
| SE345995B (zh:) | 1972-06-19 |
| DE2004038B2 (de) | 1981-07-23 |
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