ES375096A1 - Improvements in or relating to imidazoisoindole derivatives - Google Patents

Improvements in or relating to imidazoisoindole derivatives

Info

Publication number
ES375096A1
ES375096A1 ES375096A ES375096A ES375096A1 ES 375096 A1 ES375096 A1 ES 375096A1 ES 375096 A ES375096 A ES 375096A ES 375096 A ES375096 A ES 375096A ES 375096 A1 ES375096 A1 ES 375096A1
Authority
ES
Spain
Prior art keywords
imidazo
chlorophenyl
dihydro
general formula
isoindoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES375096A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES375096A1 publication Critical patent/ES375096A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04C—STRUCTURAL ELEMENTS; BUILDING MATERIALS
    • E04C2/00—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels
    • E04C2/02—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials
    • E04C2/26—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials composed of materials covered by two or more of groups E04C2/04, E04C2/08, E04C2/10 or of materials covered by one of these groups with a material not specified in one of the groups
    • E04C2/284—Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials composed of materials covered by two or more of groups E04C2/04, E04C2/08, E04C2/10 or of materials covered by one of these groups with a material not specified in one of the groups at least one of the materials being insulating

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Architecture (AREA)
  • Engineering & Computer Science (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 5 - chlorophenyl - 5 - hydroperoxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula wherein R 1 is a hydrogen or chlorine atom, are prepared by oxidation of a 5-chlorophenyl-2,3- dihydro - 5H - imidazo - [2,1-a] - isoindole of the general formula with oxygen at a temperature of from 15 to 35 C. in an ether or C 1-4 alkanol solvent The 5 - chlorophenyl - 5 - hydroperoxy - 2,3- dihydro - 5H - imidazo - [2,1-a] - isoindoles of the first general formula above may be agitated in a solvent at a temperature of from 15 to 35 C. to produce 5-chlorophenyl-5-hydroxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula Pharmaceutical compositions having appetite depressant activity comprise, as active ingredient, a 5-chlorophenyl-5-hydroperoxy-2,3-dihydro - 5H - imidazo - [2,1-a] - isoindole of the first general formula above, together with a pharmaceutically acceptable diluent or carrier, and may be administered orally or parenterally.
ES375096A 1967-12-18 1969-12-31 Improvements in or relating to imidazoisoindole derivatives Expired ES375096A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69122967A 1967-12-18 1967-12-18
US74677568A 1968-07-23 1968-07-23

Publications (1)

Publication Number Publication Date
ES375096A1 true ES375096A1 (en) 1972-08-16

Family

ID=27104753

Family Applications (3)

Application Number Title Priority Date Filing Date
ES361493A Expired ES361493A1 (en) 1967-12-18 1968-12-16 Improvements in or relating to imidazoisoindole derivatives
ES375096A Expired ES375096A1 (en) 1967-12-18 1969-12-31 Improvements in or relating to imidazoisoindole derivatives
ES375097A Expired ES375097A1 (en) 1967-12-18 1969-12-31 Improvements in or relating to imidazoisoindole derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES361493A Expired ES361493A1 (en) 1967-12-18 1968-12-16 Improvements in or relating to imidazoisoindole derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES375097A Expired ES375097A1 (en) 1967-12-18 1969-12-31 Improvements in or relating to imidazoisoindole derivatives

Country Status (8)

Country Link
BE (1) BE725569A (en)
CA (1) CA945993A (en)
CH (1) CH503044A (en)
DE (1) DE1814540A1 (en)
ES (3) ES361493A1 (en)
FR (2) FR1596124A (en)
GB (1) GB1249488A (en)
SE (1) SE342632B (en)

Also Published As

Publication number Publication date
SE342632B (en) 1972-02-14
DE1814540A1 (en) 1969-07-03
GB1249488A (en) 1971-10-13
ES361493A1 (en) 1970-12-01
CH503044A (en) 1971-02-15
FR8258M (en) 1970-10-19
FR1596124A (en) 1970-06-15
CA945993A (en) 1974-04-23
BE725569A (en) 1969-06-16
ES375097A1 (en) 1972-08-16

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