ES360566A1 - Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. - Google Patents
Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados.Info
- Publication number
- ES360566A1 ES360566A1 ES360566A ES360566A ES360566A1 ES 360566 A1 ES360566 A1 ES 360566A1 ES 360566 A ES360566 A ES 360566A ES 360566 A ES360566 A ES 360566A ES 360566 A1 ES360566 A1 ES 360566A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridoxine
- alpha
- ketoglutarate
- derivatives
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MLAUVUHGQARGDU-UHFFFAOYSA-N 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;2-oxopentanedioic acid Chemical compound OC(=O)CCC(=O)C(O)=O.CC1=NC=C(CO)C(CO)=C1O MLAUVUHGQARGDU-UHFFFAOYSA-N 0.000 title 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 4
- 235000008160 pyridoxine Nutrition 0.000 abstract 2
- 239000011677 pyridoxine Substances 0.000 abstract 2
- 229940011671 vitamin b6 Drugs 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003049 inorganic solvent Substances 0.000 abstract 1
- 229910001867 inorganic solvent Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- -1 organic base cation Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES360566A ES360566A1 (es) | 1968-11-22 | 1968-11-22 | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. |
| GB55925/69A GB1248324A (en) | 1968-11-22 | 1969-11-14 | Pyridoxine alpha-ketoglutarate and derivatives thereof |
| SE15841/69A SE368571B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-22 | 1969-11-18 | |
| DK612469AA DK133465B (da) | 1968-11-22 | 1969-11-19 | Analogifremgangsmåde til fremstilling af pyridoxin-alfa-ketoglutarat. |
| CH1730969A CH529134A (de) | 1968-11-22 | 1969-11-20 | Verfahren zur Herstellung von Pyridoxin-a-ketoglutarat-Derivaten |
| DE1958226A DE1958226C3 (de) | 1968-11-22 | 1969-11-20 | Pyridoxin-alpha-ketoglutarat |
| BE742026D BE742026A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-22 | 1969-11-21 | |
| FR696940244A FR2023937B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-22 | 1969-11-21 | |
| CH275571A CH540917A (de) | 1968-11-22 | 1971-02-25 | Verfahren zur Herstellung von Pyridoxin-a-ketoglutarat-5-hydroxytryptophansalz |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES360566A ES360566A1 (es) | 1968-11-22 | 1968-11-22 | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES360566A1 true ES360566A1 (es) | 1970-10-16 |
Family
ID=8451045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES360566A Expired ES360566A1 (es) | 1968-11-22 | 1968-11-22 | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. |
Country Status (8)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1141070B (it) * | 1980-09-22 | 1986-10-01 | Luso Farmaco Inst | Impiego dell'alfa-chetoglutarato di piridossina nella profilassi della iperlattacidemia |
| FR2531713A2 (fr) * | 1981-09-16 | 1984-02-17 | Panmedica Sa | Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant |
| DE4326763A1 (de) * | 1993-08-10 | 1995-02-16 | Kirsten Schadow | Wagen |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| ATE306489T1 (de) | 1999-03-08 | 2005-10-15 | Medicure Inc | Pyridoxal-analoge zur behandlung von störungen ausgelöst durch einen vitamin b6 mangel |
| CA2376029A1 (en) | 1999-07-13 | 2001-01-18 | Medicure Inc. | Use of pyridoxin derivatives for the treatment of diabetes and related complications |
| US6677356B1 (en) | 1999-08-24 | 2004-01-13 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
| DK1268498T3 (da) | 2000-02-29 | 2005-08-08 | Medicure Int Inc | Kardioprotektive phosphater |
| JP2003528146A (ja) | 2000-03-28 | 2003-09-24 | メディキュア インターナショナル インコーポレイテッド | 脳血管疾患の治療 |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| US6897228B2 (en) | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| WO2002004421A2 (en) | 2000-07-07 | 2002-01-17 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| JP2008517956A (ja) | 2004-10-28 | 2008-05-29 | メディキュア・インターナショナル・インコーポレーテッド | 二重の抗血小板性／抗凝固性ピリドキシン類似体 |
| US7459468B2 (en) | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
-
1968
- 1968-11-22 ES ES360566A patent/ES360566A1/es not_active Expired
-
1969
- 1969-11-14 GB GB55925/69A patent/GB1248324A/en not_active Expired
- 1969-11-18 SE SE15841/69A patent/SE368571B/xx unknown
- 1969-11-19 DK DK612469AA patent/DK133465B/da not_active IP Right Cessation
- 1969-11-20 CH CH1730969A patent/CH529134A/de not_active IP Right Cessation
- 1969-11-20 DE DE1958226A patent/DE1958226C3/de not_active Expired
- 1969-11-21 BE BE742026D patent/BE742026A/xx not_active IP Right Cessation
- 1969-11-21 FR FR696940244A patent/FR2023937B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1958226A1 (de) | 1970-05-27 |
| CH529134A (de) | 1972-10-15 |
| DK133465C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-11-22 |
| FR2023937A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-08-21 |
| GB1248324A (en) | 1971-09-29 |
| FR2023937B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-04-06 |
| BE742026A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-05-21 |
| SE368571B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-07-08 |
| DE1958226B2 (de) | 1973-07-26 |
| DK133465B (da) | 1976-05-24 |
| DE1958226C3 (de) | 1974-03-14 |
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