ES360410A1 - Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas. - Google Patents
Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas.Info
- Publication number
- ES360410A1 ES360410A1 ES360410A ES360410A ES360410A1 ES 360410 A1 ES360410 A1 ES 360410A1 ES 360410 A ES360410 A ES 360410A ES 360410 A ES360410 A ES 360410A ES 360410 A1 ES360410 A1 ES 360410A1
- Authority
- ES
- Spain
- Prior art keywords
- halogen
- methyl
- ethyl
- ethoxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 2
- JAUCQDRPVKNSMG-UHFFFAOYSA-N 2-anilino-4-chloro-N-ethylbenzamide Chemical compound C1(=CC=CC=C1)NC1=C(C(=O)NCC)C=CC(=C1)Cl JAUCQDRPVKNSMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1064767A AT280290B (de) | 1967-11-24 | 1967-11-24 | Verfahren zur Herstellung von neuen 1-Phenyl-4-alkyl-3H-1,4-benzodiazepin-2,5-[1H,4H]-dionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES360410A1 true ES360410A1 (es) | 1970-11-01 |
Family
ID=3623762
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES360410A Expired ES360410A1 (es) | 1967-11-24 | 1968-11-19 | Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas. |
| ES378977A Expired ES378977A1 (es) | 1967-11-24 | 1970-04-23 | Procedimiento para la preparacion de 1-fenil-4-alcohil-3h--1,4-benzodiazepin-2,5 (1h,4h)-dionas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES378977A Expired ES378977A1 (es) | 1967-11-24 | 1970-04-23 | Procedimiento para la preparacion de 1-fenil-4-alcohil-3h--1,4-benzodiazepin-2,5 (1h,4h)-dionas. |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT280290B (enExample) |
| BE (1) | BE724364A (enExample) |
| BR (1) | BR6804236D0 (enExample) |
| CH (1) | CH523265A (enExample) |
| DE (1) | DE1810423B2 (enExample) |
| DK (1) | DK124950B (enExample) |
| ES (2) | ES360410A1 (enExample) |
| FR (2) | FR1593335A (enExample) |
| GB (1) | GB1173540A (enExample) |
| IE (1) | IE32504B1 (enExample) |
| IL (1) | IL31146A (enExample) |
| NL (1) | NL6815755A (enExample) |
| SE (1) | SE356979B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3914216A (en) * | 1962-12-18 | 1975-10-21 | Boehringer Sohn Ingelheim | 1-Phenyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-diones |
| DE2117438A1 (de) * | 1971-04-08 | 1972-10-19 | CH. Boehringer Sohn, 6507 Ingelheim | Neue substituiert 1,3-Dihydro-2H-1 ^-benzodiazepine^-one |
| BE793460A (fr) * | 1971-12-29 | 1973-06-28 | Boehringer Sohn Ingelheim | Nouvelles 1-aryl-3h,1,4-benzodiazepine-2,5-(1h |
| JP5127096B2 (ja) * | 1999-04-30 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用 |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US7691582B2 (en) | 2002-09-27 | 2010-04-06 | The Regents Of The University Of Michigan | Methods of secretory vimentin detection and modulation |
| JP2008528448A (ja) | 2005-01-03 | 2008-07-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 新規化合物に関連する組成物および方法、ならびにその標的 |
| JP2008545757A (ja) | 2005-06-01 | 2008-12-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 溶媒和されていないベンゾジアゼピン組成物および方法 |
| EP1948191B1 (en) | 2005-11-01 | 2013-01-16 | The Regents of the University of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US7759338B2 (en) | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| EP2418206A3 (en) | 2006-06-09 | 2012-06-27 | The Regents of the University of Michigan | Benzodiazepine derivatives useful in the treatment of autoimmune disorders |
| KR101164718B1 (ko) | 2007-03-09 | 2012-07-11 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 신규 화합물 및 이의 표적에 관한 조성물 및 방법 |
| JP2010526825A (ja) * | 2007-05-10 | 2010-08-05 | エーエムアール テクノロジー インコーポレイテッド | アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用 |
| MX2010002732A (es) | 2007-09-14 | 2010-06-02 | Univ Michigan | Inhibidores de f1f0-atpasa y metodos relacionados. |
| CN101918375A (zh) | 2007-11-06 | 2010-12-15 | 密歇根大学董事会 | 在皮肤病症的治疗中有用的苯并二氮杂*酮化合物 |
| US8497307B2 (en) | 2008-09-11 | 2013-07-30 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| EP2470020A4 (en) | 2009-09-18 | 2013-03-13 | Univ Michigan | BENZODIAZEPINONE COMPOUNDS AND TREATMENT METHODS THEREWITH |
| JP5856064B2 (ja) | 2009-11-17 | 2016-02-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物 |
| WO2011062765A2 (en) | 2009-11-17 | 2011-05-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| CA2923835C (en) * | 2013-09-11 | 2022-11-29 | The Administrators Of The Tulane Educational Fund | Novel anthranilic amides and the use thereof |
-
1967
- 1967-11-24 AT AT1064767A patent/AT280290B/de not_active IP Right Cessation
-
1968
- 1968-11-05 NL NL6815755A patent/NL6815755A/xx unknown
- 1968-11-06 SE SE15032/68A patent/SE356979B/xx unknown
- 1968-11-19 ES ES360410A patent/ES360410A1/es not_active Expired
- 1968-11-20 DK DK566968AA patent/DK124950B/da unknown
- 1968-11-22 CH CH1742668A patent/CH523265A/de not_active IP Right Cessation
- 1968-11-22 BR BR204236/68A patent/BR6804236D0/pt unknown
- 1968-11-22 DE DE19681810423 patent/DE1810423B2/de active Granted
- 1968-11-22 IE IE1425/68A patent/IE32504B1/xx unknown
- 1968-11-22 BE BE724364A patent/BE724364A/fr unknown
- 1968-11-22 FR FR1593335D patent/FR1593335A/fr not_active Expired
- 1968-11-24 IL IL31146A patent/IL31146A/en unknown
- 1968-11-25 GB GB55844/68A patent/GB1173540A/en not_active Expired
-
1969
- 1969-02-21 FR FR183259A patent/FR8310M/fr not_active Expired
-
1970
- 1970-04-23 ES ES378977A patent/ES378977A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6815755A (enExample) | 1969-05-28 |
| AT280290B (de) | 1970-04-10 |
| GB1173540A (en) | 1969-12-10 |
| IE32504L (en) | 1969-05-24 |
| BE724364A (enExample) | 1969-05-22 |
| CH523265A (de) | 1972-05-31 |
| DE1810423C3 (enExample) | 1973-10-11 |
| IE32504B1 (en) | 1973-08-22 |
| DE1810423A1 (de) | 1969-10-09 |
| DK124950B (da) | 1972-12-11 |
| ES378977A1 (es) | 1973-01-16 |
| IL31146A (en) | 1972-04-27 |
| FR1593335A (enExample) | 1970-05-25 |
| FR8310M (enExample) | 1970-11-23 |
| BR6804236D0 (pt) | 1973-02-08 |
| IL31146A0 (en) | 1969-01-29 |
| DE1810423B2 (de) | 1973-03-22 |
| SE356979B (enExample) | 1973-06-12 |
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