ES360410A1 - Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas. - Google Patents
Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas.Info
- Publication number
- ES360410A1 ES360410A1 ES360410A ES360410A ES360410A1 ES 360410 A1 ES360410 A1 ES 360410A1 ES 360410 A ES360410 A ES 360410A ES 360410 A ES360410 A ES 360410A ES 360410 A1 ES360410 A1 ES 360410A1
- Authority
- ES
- Spain
- Prior art keywords
- halogen
- methyl
- ethyl
- ethoxy
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 2
- JAUCQDRPVKNSMG-UHFFFAOYSA-N 2-anilino-4-chloro-N-ethylbenzamide Chemical compound C1(=CC=CC=C1)NC1=C(C(=O)NCC)C=CC(=C1)Cl JAUCQDRPVKNSMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1064767A AT280290B (de) | 1967-11-24 | 1967-11-24 | Verfahren zur Herstellung von neuen 1-Phenyl-4-alkyl-3H-1,4-benzodiazepin-2,5-[1H,4H]-dionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES360410A1 true ES360410A1 (es) | 1970-11-01 |
Family
ID=3623762
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES360410A Expired ES360410A1 (es) | 1967-11-24 | 1968-11-19 | Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas. |
| ES378977A Expired ES378977A1 (es) | 1967-11-24 | 1970-04-23 | Procedimiento para la preparacion de 1-fenil-4-alcohil-3h--1,4-benzodiazepin-2,5 (1h,4h)-dionas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES378977A Expired ES378977A1 (es) | 1967-11-24 | 1970-04-23 | Procedimiento para la preparacion de 1-fenil-4-alcohil-3h--1,4-benzodiazepin-2,5 (1h,4h)-dionas. |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT280290B (enExample) |
| BE (1) | BE724364A (enExample) |
| BR (1) | BR6804236D0 (enExample) |
| CH (1) | CH523265A (enExample) |
| DE (1) | DE1810423B2 (enExample) |
| DK (1) | DK124950B (enExample) |
| ES (2) | ES360410A1 (enExample) |
| FR (2) | FR1593335A (enExample) |
| GB (1) | GB1173540A (enExample) |
| IE (1) | IE32504B1 (enExample) |
| IL (1) | IL31146A (enExample) |
| NL (1) | NL6815755A (enExample) |
| SE (1) | SE356979B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3914216A (en) * | 1962-12-18 | 1975-10-21 | Boehringer Sohn Ingelheim | 1-Phenyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-diones |
| DE2117438A1 (de) * | 1971-04-08 | 1972-10-19 | CH. Boehringer Sohn, 6507 Ingelheim | Neue substituiert 1,3-Dihydro-2H-1 ^-benzodiazepine^-one |
| BE793460A (fr) * | 1971-12-29 | 1973-06-28 | Boehringer Sohn Ingelheim | Nouvelles 1-aryl-3h,1,4-benzodiazepine-2,5-(1h |
| DK1143946T3 (da) * | 1999-04-30 | 2004-06-07 | Univ Michigan | Anvendelse af benzodiazepiner til behandling af autoimmune sygdomme induceret af apoptose |
| US7276348B2 (en) | 1999-04-30 | 2007-10-02 | Regents Of The University Of Michigan | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| US20060025388A1 (en) | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
| US7691582B2 (en) | 2002-09-27 | 2010-04-06 | The Regents Of The University Of Michigan | Methods of secretory vimentin detection and modulation |
| EP1845996A4 (en) | 2005-01-03 | 2009-04-29 | Univ Michigan | COMPOSITIONS AND METHODS RELATED TO NEW CONNECTIONS AND TARGETS THEREFOR |
| US20070043033A1 (en) | 2005-06-01 | 2007-02-22 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| NZ568254A (en) | 2005-11-01 | 2011-06-30 | Univ Michigan | 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases |
| US7759338B2 (en) | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| EP2418206A3 (en) | 2006-06-09 | 2012-06-27 | The Regents of the University of Michigan | Benzodiazepine derivatives useful in the treatment of autoimmune disorders |
| CA2680017C (en) | 2007-03-09 | 2013-11-12 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| CN101686983A (zh) * | 2007-05-10 | 2010-03-31 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并-1,4-二氮杂䓬及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
| AU2008298870C1 (en) | 2007-09-14 | 2014-10-09 | The Regents Of The University Of Michigan | F1F0-ATPase inhibitors and related methods |
| JP5539212B2 (ja) | 2007-11-06 | 2014-07-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 皮膚症状の治療に有用なベンゾジアゼピノン化合物 |
| JP5567573B2 (ja) | 2008-09-11 | 2014-08-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アリールグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびそれと関連する方法 |
| US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| WO2011035124A1 (en) | 2009-09-18 | 2011-03-24 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| JP5856063B2 (ja) | 2009-11-17 | 2016-02-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物 |
| CN102753544A (zh) | 2009-11-17 | 2012-10-24 | 密执安大学评议会 | 具有治疗性能的1，4-苯并二氮杂*-2，5-二酮和相关化合物 |
| EP3043790B1 (en) | 2013-09-11 | 2021-05-26 | The Administrators of the Tulane Educational Fund | Novel anthranilic amides and the use thereof |
-
1967
- 1967-11-24 AT AT1064767A patent/AT280290B/de not_active IP Right Cessation
-
1968
- 1968-11-05 NL NL6815755A patent/NL6815755A/xx unknown
- 1968-11-06 SE SE15032/68A patent/SE356979B/xx unknown
- 1968-11-19 ES ES360410A patent/ES360410A1/es not_active Expired
- 1968-11-20 DK DK566968AA patent/DK124950B/da unknown
- 1968-11-22 BE BE724364A patent/BE724364A/fr unknown
- 1968-11-22 IE IE1425/68A patent/IE32504B1/xx unknown
- 1968-11-22 DE DE19681810423 patent/DE1810423B2/de active Granted
- 1968-11-22 FR FR1593335D patent/FR1593335A/fr not_active Expired
- 1968-11-22 CH CH1742668A patent/CH523265A/de not_active IP Right Cessation
- 1968-11-22 BR BR204236/68A patent/BR6804236D0/pt unknown
- 1968-11-24 IL IL31146A patent/IL31146A/en unknown
- 1968-11-25 GB GB55844/68A patent/GB1173540A/en not_active Expired
-
1969
- 1969-02-21 FR FR183259A patent/FR8310M/fr not_active Expired
-
1970
- 1970-04-23 ES ES378977A patent/ES378977A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6804236D0 (pt) | 1973-02-08 |
| SE356979B (enExample) | 1973-06-12 |
| DK124950B (da) | 1972-12-11 |
| CH523265A (de) | 1972-05-31 |
| NL6815755A (enExample) | 1969-05-28 |
| FR1593335A (enExample) | 1970-05-25 |
| DE1810423C3 (enExample) | 1973-10-11 |
| IL31146A0 (en) | 1969-01-29 |
| IE32504L (en) | 1969-05-24 |
| IE32504B1 (en) | 1973-08-22 |
| GB1173540A (en) | 1969-12-10 |
| AT280290B (de) | 1970-04-10 |
| BE724364A (enExample) | 1969-05-22 |
| DE1810423B2 (de) | 1973-03-22 |
| FR8310M (enExample) | 1970-11-23 |
| IL31146A (en) | 1972-04-27 |
| ES378977A1 (es) | 1973-01-16 |
| DE1810423A1 (de) | 1969-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES360410A1 (es) | Procedimiento para la preparacion de 1-fenil - 4 - alcohil-3h-1,4-benzodiazepin-2,5 (1h, 4h)-dionas. | |
| GB1432576A (en) | Substituted phenylacetic acids | |
| YU42116B (en) | Process for obtaining ethanol amine derivatives | |
| GB1503680A (en) | Pharmaceutical preparations having psychotropic activity and process for their manufacture | |
| GB1474882A (en) | Alpha-aminomethyl-5-hydroxy-2-pyridinemethanols | |
| GB1410755A (en) | Tricyclic substituted aminoalcohols and the preparation thereof | |
| GB1188846A (en) | Thiazole Derivatives | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| IE38979L (en) | Tetrazolyl - quinoxalinecarboxamide derivatives | |
| GB1210809A (en) | Benzodiazepine derivatives | |
| GB984471A (en) | Anthranilic acid esters and methods for producing the same | |
| GB1523598A (en) | Tripeptides | |
| GB1443692A (en) | 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof | |
| GB1434805A (en) | 5-phenoxy-4-amino pyrimidines | |
| GB1494560A (en) | 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their preparation | |
| ES376688A1 (es) | Procedimiento para la produccion de una 3h-1,4-benzodiacepi-ra. | |
| GB1433103A (en) | Pharmacologically active pyrrolodiazepines | |
| ES449689A1 (es) | Procedimiento para la preparacion de n (fenileter sustitui- das bencil) alcanodiaminas. | |
| GB1345214A (en) | Isoxazoles | |
| GB1408984A (en) | Beta-adrenergic blocking aminopropanols | |
| GB1468079A (en) | Ethanolamine derivatives | |
| GB1514113A (en) | Therapeutic compositions containing dimercapto-diethyl ether derivatives | |
| SE333735B (enExample) | ||
| GB1333700A (en) | Phenothiazine derivatives | |
| IE32778B1 (en) | Improvements in or relating to nitrogen-containing heterocyclic derivatives |