ES354352A1 - Un procedimiento para la preparacion de levo - 1 - n-butil-2',6'-pipecoloxiliduro. - Google Patents
Un procedimiento para la preparacion de levo - 1 - n-butil-2',6'-pipecoloxiliduro.Info
- Publication number
- ES354352A1 ES354352A1 ES354352A ES354352A ES354352A1 ES 354352 A1 ES354352 A1 ES 354352A1 ES 354352 A ES354352 A ES 354352A ES 354352 A ES354352 A ES 354352A ES 354352 A1 ES354352 A1 ES 354352A1
- Authority
- ES
- Spain
- Prior art keywords
- pipecoloxylidide
- butyl
- tartrate
- levo
- dextro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 8
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 239000002585 base Substances 0.000 abstract 3
- 150000007529 inorganic bases Chemical class 0.000 abstract 3
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000010899 nucleation Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229960001270 d- tartaric acid Drugs 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- -1 n-butyl halide Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63927767A | 1967-05-18 | 1967-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES354352A1 true ES354352A1 (es) | 1969-11-01 |
Family
ID=24563449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES354352A Expired ES354352A1 (es) | 1967-05-18 | 1968-05-16 | Un procedimiento para la preparacion de levo - 1 - n-butil-2',6'-pipecoloxiliduro. |
Country Status (13)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60502054A (ja) * | 1983-08-01 | 1985-11-28 | アストラ・レケメデル・アクチボラグ | Ｌ―Ｎ―ｎ―プロピルピペコリン酸―２，６―キシリダイドおよびその製造方法 |
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
| PL183210B1 (pl) * | 1994-10-25 | 2002-06-28 | Darwin Discovery Ltd | Sposób wytwarzania wzbogaconej optycznie bupiwakainy |
| SE9501808D0 (sv) * | 1995-05-16 | 1995-05-16 | Astra Ab | New process |
| KR100844336B1 (ko) * | 2007-01-16 | 2008-07-07 | 하나제약 주식회사 | 레보부피바카인 및 이의 염산염의 신규한 제조방법 |
| WO2014009964A1 (en) * | 2012-07-11 | 2014-01-16 | Neon Laboratories Limited | Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide |
| CN105315196A (zh) * | 2015-11-28 | 2016-02-10 | 山东齐都药业有限公司 | 一种高纯度盐酸左布比卡因精制方法 |
| CN109896992A (zh) * | 2017-12-08 | 2019-06-18 | 武汉软件工程职业学院 | 制备离子液体的方法及其应用 |
-
1968
- 1968-05-02 SE SE05905/68A patent/SE341404B/xx unknown
- 1968-05-07 IL IL29958A patent/IL29958A/xx unknown
- 1968-05-10 NO NO1819/68A patent/NO124540B/no unknown
- 1968-05-10 GB GB22420/68A patent/GB1180712A/en not_active Expired
- 1968-05-14 DE DE1770408A patent/DE1770408C3/de not_active Expired
- 1968-05-15 BE BE715188D patent/BE715188A/xx unknown
- 1968-05-16 ES ES354352A patent/ES354352A1/es not_active Expired
- 1968-05-16 DK DK226968AA patent/DK129234B/da unknown
- 1968-05-17 FR FR1583872D patent/FR1583872A/fr not_active Expired
- 1968-05-17 NL NL6806995A patent/NL6806995A/xx unknown
- 1968-05-17 AT AT475368A patent/AT284843B/de not_active IP Right Cessation
- 1968-05-17 FI FI681394A patent/FI50333C/fi active
- 1968-05-17 CH CH733568A patent/CH498834A/de not_active IP Right Cessation
- 1968-05-17 AT AT1097469A patent/AT286298B/de not_active IP Right Cessation
- 1968-08-16 FR FR163282A patent/FR8160M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT286298B (de) | 1970-12-10 |
| SE341404B (enrdf_load_stackoverflow) | 1971-12-27 |
| IL29958A0 (en) | 1968-07-25 |
| DK129234C (enrdf_load_stackoverflow) | 1975-02-03 |
| IL29958A (en) | 1971-04-28 |
| NO124540B (enrdf_load_stackoverflow) | 1972-05-02 |
| NL6806995A (enrdf_load_stackoverflow) | 1968-11-19 |
| FI50333B (enrdf_load_stackoverflow) | 1975-10-31 |
| DE1770408C3 (de) | 1974-11-07 |
| DE1770408B2 (enrdf_load_stackoverflow) | 1974-04-11 |
| FI50333C (fi) | 1976-02-10 |
| FR1583872A (enrdf_load_stackoverflow) | 1969-12-05 |
| DE1770408A1 (de) | 1971-10-21 |
| DK129234B (da) | 1974-09-16 |
| GB1180712A (en) | 1970-02-11 |
| BE715188A (enrdf_load_stackoverflow) | 1968-09-30 |
| FR8160M (enrdf_load_stackoverflow) | 1970-08-24 |
| CH498834A (de) | 1970-11-15 |
| AT284843B (de) | 1970-09-25 |
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