ES350574A1 - Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas. - Google Patents
Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas.Info
- Publication number
- ES350574A1 ES350574A1 ES350574A ES350574A ES350574A1 ES 350574 A1 ES350574 A1 ES 350574A1 ES 350574 A ES350574 A ES 350574A ES 350574 A ES350574 A ES 350574A ES 350574 A1 ES350574 A1 ES 350574A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- prepared
- tetrahydro
- aziridinyl
- ethane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 3
- 150000007522 mineralic acids Chemical class 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- QSHMWSLFNQLCNI-UHFFFAOYSA-N 1-(2-phenylethyl)aziridine Chemical compound C1CN1CCC1=CC=CC=C1 QSHMWSLFNQLCNI-UHFFFAOYSA-N 0.000 abstract 2
- ZJIUEDYXZUIMNV-UHFFFAOYSA-N 7-chloro-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound C1CNCCC2=CC(Cl)=CC=C21 ZJIUEDYXZUIMNV-UHFFFAOYSA-N 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- LDJWTBUTKPXDFA-UHFFFAOYSA-N 1-[2-(4-chlorophenyl)ethyl]aziridine Chemical compound ClC1=CC=C(C=C1)CCN1CC1 LDJWTBUTKPXDFA-UHFFFAOYSA-N 0.000 abstract 1
- KTZVZZJJVJQZHV-UHFFFAOYSA-N 1-chloro-4-ethenylbenzene Chemical compound ClC1=CC=C(C=C)C=C1 KTZVZZJJVJQZHV-UHFFFAOYSA-N 0.000 abstract 1
- MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002891 anorexigenic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000007925 phenylethylamine derivatives Chemical class 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Drawers Of Furniture (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH238667A CH481110A (de) | 1967-02-17 | 1967-02-17 | Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen |
| CH1167167A CH488705A (de) | 1967-02-17 | 1967-08-18 | Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES350574A1 true ES350574A1 (es) | 1969-11-16 |
Family
ID=25690322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES350574A Expired ES350574A1 (es) | 1967-02-17 | 1968-02-16 | Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3652543A (cg-RX-API-DMAC7.html) |
| AT (1) | AT275533B (cg-RX-API-DMAC7.html) |
| BE (1) | BE710872A (cg-RX-API-DMAC7.html) |
| CH (2) | CH481110A (cg-RX-API-DMAC7.html) |
| DE (2) | DE1695124A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK115473B (cg-RX-API-DMAC7.html) |
| ES (1) | ES350574A1 (cg-RX-API-DMAC7.html) |
| FR (2) | FR1561479A (cg-RX-API-DMAC7.html) |
| GB (2) | GB1221324A (cg-RX-API-DMAC7.html) |
| IL (1) | IL29485A (cg-RX-API-DMAC7.html) |
| NL (1) | NL6802257A (cg-RX-API-DMAC7.html) |
| NO (1) | NO124369B (cg-RX-API-DMAC7.html) |
| SE (1) | SE342043B (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT289812B (de) * | 1968-08-09 | 1971-05-10 | Geigy Ag J R | Verfahren zur Herstellung des neuen 2-Methyl-7-chlor-2,3,4,5-tetrahydro-1H-3-benzazepins sowie seiner Säureadditionssalze |
| DE2016136A1 (de) * | 1970-04-04 | 1971-10-14 | C H Boehnnger Sohn, 6507 Ingel heim | Neue 7 Acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine |
| DE2143204C3 (de) * | 1971-08-28 | 1979-09-27 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis |
| FR2171879A1 (en) * | 1972-02-14 | 1973-09-28 | Pennwalt Corp | 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc |
| EP0161350A1 (en) * | 1981-11-27 | 1985-11-21 | Smithkline Beckman Corporation | Process for preparing benzazepines |
| US4541954A (en) * | 1984-09-05 | 1985-09-17 | Smithkline Beckman Corporation | Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| US4973586A (en) * | 1986-01-16 | 1990-11-27 | Schering Corporation | Fused benzazepines, compositions of, and medical use thereof |
| US5302716A (en) * | 1986-01-16 | 1994-04-12 | Schering Corporation | Fused benzazepines |
| JPH0681745B2 (ja) * | 1986-01-16 | 1994-10-19 | シェリング・コ−ポレ−ション | 縮合ベンゾアゼピン |
| US5015639A (en) * | 1987-03-27 | 1991-05-14 | Schering Corporation | Substituted benzazepines, their preparation and pharmaceutical compositions containing them |
| JPH0678317B2 (ja) * | 1987-07-15 | 1994-10-05 | シェリング・コーポレーション | 縮合ベンズアゼピン |
| CA2075181C (en) * | 1990-02-02 | 1997-12-09 | Theodros Asberom | 4,5-bridged-2,3,4,5-tetrahydro-1h-3-benzazepine-7-ols |
| US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| US20030220661A1 (en) * | 2002-05-21 | 2003-11-27 | Heartstent Corporation | Transmyocardial implant delivery system |
| EA016558B1 (ru) * | 2003-06-17 | 2012-05-30 | Арена Фармасьютикалз, Инк. | Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором |
| SI2332921T1 (sl) | 2003-06-17 | 2016-06-30 | Arena Pharmaceuticals, Inc. | 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid |
| US20080009478A1 (en) * | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| US20070275949A1 (en) * | 2003-10-22 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases |
| US8168624B2 (en) | 2004-12-21 | 2012-05-01 | Arena Pharmaceuticals, Inc. | Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| EP2111859A1 (en) | 2004-12-23 | 2009-10-28 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulator compositions and methods of use |
| JP5199997B2 (ja) * | 2006-04-03 | 2013-05-15 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス |
| WO2008070111A2 (en) * | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| CN102015591B (zh) * | 2008-03-04 | 2014-01-29 | 艾尼纳制药公司 | 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 |
| WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| WO2011071136A1 (ja) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
| SG10201506870PA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
| KR20180094131A (ko) | 2010-09-01 | 2018-08-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신장 손상을 갖는 개체에 대한 로카세린의 투여 |
| SG188362A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| WO2014058441A1 (en) | 2012-10-09 | 2014-04-17 | Arena Pharmaceuticals, Inc. | Method of weight management |
-
1967
- 1967-02-17 CH CH238667A patent/CH481110A/de not_active IP Right Cessation
- 1967-08-18 CH CH1167167A patent/CH488705A/de not_active IP Right Cessation
-
1968
- 1968-02-15 US US705612A patent/US3652543A/en not_active Expired - Lifetime
- 1968-02-16 BE BE710872D patent/BE710872A/xx unknown
- 1968-02-16 GB GB7601/68A patent/GB1221324A/en not_active Expired
- 1968-02-16 DK DK63068AA patent/DK115473B/da unknown
- 1968-02-16 DE DE19681695124 patent/DE1695124A1/de active Pending
- 1968-02-16 AT AT148868A patent/AT275533B/de active
- 1968-02-16 NO NO0598/68A patent/NO124369B/no unknown
- 1968-02-16 FR FR1561479D patent/FR1561479A/fr not_active Expired
- 1968-02-16 SE SE2047/68A patent/SE342043B/xx unknown
- 1968-02-16 NL NL6802257A patent/NL6802257A/xx unknown
- 1968-02-16 FR FR1560654D patent/FR1560654A/fr not_active Expired
- 1968-02-16 DE DE19681668915 patent/DE1668915A1/de active Pending
- 1968-02-16 ES ES350574A patent/ES350574A1/es not_active Expired
- 1968-02-16 IL IL29485A patent/IL29485A/xx unknown
- 1968-02-16 GB GB7600/68A patent/GB1222397A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO124369B (cg-RX-API-DMAC7.html) | 1972-04-10 |
| DE1668915A1 (de) | 1972-03-09 |
| FR1560654A (cg-RX-API-DMAC7.html) | 1969-03-21 |
| US3652543A (en) | 1972-03-28 |
| GB1222397A (en) | 1971-02-10 |
| SE342043B (cg-RX-API-DMAC7.html) | 1972-01-24 |
| DE1695124A1 (de) | 1970-08-20 |
| IL29485A (en) | 1971-07-28 |
| CH488705A (de) | 1970-04-15 |
| BE710872A (cg-RX-API-DMAC7.html) | 1968-08-16 |
| CH481110A (de) | 1969-11-15 |
| DK115473B (da) | 1969-10-13 |
| GB1221324A (en) | 1971-02-03 |
| FR1561479A (cg-RX-API-DMAC7.html) | 1969-03-28 |
| AT275533B (de) | 1969-10-27 |
| NL6802257A (cg-RX-API-DMAC7.html) | 1968-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES350574A1 (es) | Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzazepinas. | |
| IE35909B1 (en) | Acylxylidide local anaesthetics | |
| GB1254332A (en) | Amino acids and their derivatives and processes for preparing them | |
| GB1048199A (en) | New bisalkanolamine derivatives and a process for their preparation | |
| ES374549A1 (es) | Procedimiento de preparacion de nuevos derivados del acido tiazolil benzoico. | |
| GB1308028A (en) | Thiazolylbenzoic acid derivatives and a process for their manufactur | |
| GB1394504A (en) | 1,2-bis-4-phenyl-1-piperazinyl-ethane derivatives | |
| GB1500063A (en) | Indolinone and fluorenone derivatives | |
| ES469473A1 (es) | Un procedimiento para la preparacion de derivados de n-fenil-n-(4-piperidinil) amida | |
| GB1191237A (en) | 0,3-Diazacyclo alkeno[2,1-a]isoindole Derivatives and a process for the mnufacture thereof | |
| GB1380145A (en) | Acetamidine derivatives process for preparing the same and pharma ceutical uses thereof | |
| ES347622A1 (es) | Procedimiento para la preparacion de derivados n-(amino terciario alquil) amida. | |
| GB1047245A (cg-RX-API-DMAC7.html) | ||
| GB863550A (en) | 3-mercapto-phenthiazines | |
| ES351470A1 (es) | Un procedimiento de sintesis de nuevas 2-arilalcohiloxi- benzamidas. | |
| GB1449802A (en) | Piperazine derivatives and compositions containing them for treating parkinsons disease | |
| ES311285A1 (es) | Procedimiento de preparaciën de un nuevo derivado de la triazolona | |
| ES367958A1 (es) | Procedimiento para la obtencion de bis-(ariloxi) acetami- das. | |
| GB1071471A (en) | Amides of 2,6-dichloro-aniline and a nitrogen substituted amino-acid | |
| GB1203430A (en) | Heterocyclic spiro compounds | |
| GB1205687A (en) | Aminoalkanol esters and their pharmaceutically acceptable acid-addition salts, and production thereof | |
| GB1054655A (cg-RX-API-DMAC7.html) | ||
| ES368607A1 (es) | Un procedimiento para la produccion de compuestos seleccio-nados del grupo de los 1-sustituido-2,5-difenilpirroles. | |
| ES370334A2 (es) | Procedimiento para la preparacion de 2,3,4,5-tetrahidro-1h-3-benzacepina. | |
| GB1455169A (en) | Amidic derivatives of nicotinic acid |