DK115473B - Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. - Google Patents

Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Info

Publication number
DK115473B
DK115473B DK63068AA DK63068A DK115473B DK 115473 B DK115473 B DK 115473B DK 63068A A DK63068A A DK 63068AA DK 63068 A DK63068 A DK 63068A DK 115473 B DK115473 B DK 115473B
Authority
DK
Denmark
Prior art keywords
benzazepines
tetrahydro
preparation
acid addition
addition salts
Prior art date
Application number
DK63068AA
Other languages
Danish (da)
English (en)
Inventor
K Hoegerle
E Habicht
Original Assignee
Geigy Ag J R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geigy Ag J R filed Critical Geigy Ag J R
Publication of DK115473B publication Critical patent/DK115473B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Drawers Of Furniture (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK63068AA 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. DK115473B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH238667A CH481110A (de) 1967-02-17 1967-02-17 Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
CH1167167A CH488705A (de) 1967-02-17 1967-08-18 Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates

Publications (1)

Publication Number Publication Date
DK115473B true DK115473B (da) 1969-10-13

Family

ID=25690322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK63068AA DK115473B (da) 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Country Status (13)

Country Link
US (1) US3652543A (cg-RX-API-DMAC7.html)
AT (1) AT275533B (cg-RX-API-DMAC7.html)
BE (1) BE710872A (cg-RX-API-DMAC7.html)
CH (2) CH481110A (cg-RX-API-DMAC7.html)
DE (2) DE1695124A1 (cg-RX-API-DMAC7.html)
DK (1) DK115473B (cg-RX-API-DMAC7.html)
ES (1) ES350574A1 (cg-RX-API-DMAC7.html)
FR (2) FR1561479A (cg-RX-API-DMAC7.html)
GB (2) GB1221324A (cg-RX-API-DMAC7.html)
IL (1) IL29485A (cg-RX-API-DMAC7.html)
NL (1) NL6802257A (cg-RX-API-DMAC7.html)
NO (1) NO124369B (cg-RX-API-DMAC7.html)
SE (1) SE342043B (cg-RX-API-DMAC7.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT289812B (de) * 1968-08-09 1971-05-10 Geigy Ag J R Verfahren zur Herstellung des neuen 2-Methyl-7-chlor-2,3,4,5-tetrahydro-1H-3-benzazepins sowie seiner Säureadditionssalze
DE2016136A1 (de) * 1970-04-04 1971-10-14 C H Boehnnger Sohn, 6507 Ingel heim Neue 7 Acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine
DE2143204C3 (de) * 1971-08-28 1979-09-27 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
JPH0681745B2 (ja) * 1986-01-16 1994-10-19 シェリング・コ−ポレ−ション 縮合ベンゾアゼピン
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
JPH0678317B2 (ja) * 1987-07-15 1994-10-05 シェリング・コーポレーション 縮合ベンズアゼピン
CA2075181C (en) * 1990-02-02 1997-12-09 Theodros Asberom 4,5-bridged-2,3,4,5-tetrahydro-1h-3-benzazepine-7-ols
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US8168624B2 (en) 2004-12-21 2012-05-01 Arena Pharmaceuticals, Inc. Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EP2111859A1 (en) 2004-12-23 2009-10-28 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (ja) * 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
CN102015591B (zh) * 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
KR20180094131A (ko) 2010-09-01 2018-08-22 에자이 알앤드디 매니지먼트 가부시키가이샤 신장 손상을 갖는 개체에 대한 로카세린의 투여
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Also Published As

Publication number Publication date
NO124369B (cg-RX-API-DMAC7.html) 1972-04-10
DE1668915A1 (de) 1972-03-09
FR1560654A (cg-RX-API-DMAC7.html) 1969-03-21
US3652543A (en) 1972-03-28
GB1222397A (en) 1971-02-10
SE342043B (cg-RX-API-DMAC7.html) 1972-01-24
DE1695124A1 (de) 1970-08-20
IL29485A (en) 1971-07-28
CH488705A (de) 1970-04-15
BE710872A (cg-RX-API-DMAC7.html) 1968-08-16
CH481110A (de) 1969-11-15
ES350574A1 (es) 1969-11-16
GB1221324A (en) 1971-02-03
FR1561479A (cg-RX-API-DMAC7.html) 1969-03-28
AT275533B (de) 1969-10-27
NL6802257A (cg-RX-API-DMAC7.html) 1968-08-19

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