ES321379A1 - Procedure for preparation of derivatives pirido benzo diacepina. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of derivatives pirido benzo diacepina. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES321379A1
ES321379A1 ES0321379A ES321379A ES321379A1 ES 321379 A1 ES321379 A1 ES 321379A1 ES 0321379 A ES0321379 A ES 0321379A ES 321379 A ES321379 A ES 321379A ES 321379 A1 ES321379 A1 ES 321379A1
Authority
ES
Spain
Prior art keywords
formula
see formula
compound
radical
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0321379A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
U P SA Lab
Original Assignee
U P SA Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by U P SA Lab filed Critical U P SA Lab
Publication of ES321379A1 publication Critical patent/ES321379A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other Surface Treatments For Metallic Materials (AREA)

Abstract

Procedure for the preparation of pyrido benzo diazepine derivatives, especially useful as anti-depressant agents of the central nervous system, and which respond to the following formula: **(See formula)** in which R1 and R3 each represent a hydrogen atom, or a halogen atom, or an alkyl radical of not more than 4 carbon atoms; R2 represents a hydrogen atom or a radical **(See formula)** A representing a branched or straight lower alkylene radical containing at least 6 carbon atoms, R4 and R5 being alkyl radicals of less than 4 carbon atoms and that can participate with the nitrogen atom to which they are attached in a heterocyclic, such as piperidino, morpholino, etc., and their acid addition salts, characterized in that a compound of formula I in which R2 is H is first prepared by condensation of a halogen-2 nicotinic acid of formula: **(See formula)** in which Hal represents a halogen atom, preferably chlorine or bromine, with the ortho-phenylene diamine corresponding to the formula: **(See formula)** R1 and R3 being defined as above, preferably using approximately 2 moles of diamine per mole of halogen-nicotinic acid, and heating the reactants, preferably at 80º -160ºC, and then the resulting compound is preferably reacted in the presence of a basic condensing agent such as sodium amide and in an inert solvent such as a dioxane-benzene mixture, with a compound of the formula: **(See formula)** in which Hal, R4 and R5 are defined as above, preferably at a reaction temperature of about 80º to 140ºC, to form the compound of formula I in which R2 is the radical (see formula) (Machine-translation by Google Translate, not legally binding)
ES0321379A 1965-01-05 1965-12-31 Procedure for preparation of derivatives pirido benzo diacepina. (Machine-translation by Google Translate, not legally binding) Expired ES321379A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB43865 1965-01-05

Publications (1)

Publication Number Publication Date
ES321379A1 true ES321379A1 (en) 1966-10-16

Family

ID=9704345

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0321379A Expired ES321379A1 (en) 1965-01-05 1965-12-31 Procedure for preparation of derivatives pirido benzo diacepina. (Machine-translation by Google Translate, not legally binding)

Country Status (10)

Country Link
AT (1) AT268286B (en)
BE (1) BE674041A (en)
CH (1) CH460796A (en)
DE (1) DE1595891B2 (en)
DK (1) DK114064B (en)
ES (1) ES321379A1 (en)
FR (1) FR6006M (en)
NL (1) NL146823B (en)
NO (1) NO121041B (en)
SE (2) SE314989B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2850654A1 (en) * 2003-02-03 2004-08-06 Servier Lab NOVEL TRICYCLIC AZEPINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
SE320084B (en) 1970-02-02
FR6006M (en) 1968-05-06
AT268286B (en) 1969-02-10
BE674041A (en) 1966-04-15
DE1595891A1 (en) 1969-12-11
DK114064B (en) 1969-05-27
NO121041B (en) 1971-01-11
DE1595891B2 (en) 1977-06-16
NL6600065A (en) 1966-07-06
CH460796A (en) 1968-08-15
NL146823B (en) 1975-08-15
SE314989B (en) 1969-09-22

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