ES3060954T3 - The 5ht agonist clemizole for use in treating epilepsy disorders - Google Patents

The 5ht agonist clemizole for use in treating epilepsy disorders

Info

Publication number
ES3060954T3
ES3060954T3 ES22157142T ES22157142T ES3060954T3 ES 3060954 T3 ES3060954 T3 ES 3060954T3 ES 22157142 T ES22157142 T ES 22157142T ES 22157142 T ES22157142 T ES 22157142T ES 3060954 T3 ES3060954 T3 ES 3060954T3
Authority
ES
Spain
Prior art keywords
pharmaceutically acceptable
clemizole
acceptable salt
administered
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES22157142T
Other languages
English (en)
Spanish (es)
Inventor
Scott Baraban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California, San Diego
Original Assignee
University of California Berkeley
University of California, San Diego
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California, San Diego filed Critical University of California Berkeley
Application granted granted Critical
Publication of ES3060954T3 publication Critical patent/ES3060954T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES22157142T 2015-02-25 2016-02-24 The 5ht agonist clemizole for use in treating epilepsy disorders Active ES3060954T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562120726P 2015-02-25 2015-02-25

Publications (1)

Publication Number Publication Date
ES3060954T3 true ES3060954T3 (en) 2026-03-30

Family

ID=56789223

Family Applications (2)

Application Number Title Priority Date Filing Date
ES22157142T Active ES3060954T3 (en) 2015-02-25 2016-02-24 The 5ht agonist clemizole for use in treating epilepsy disorders
ES16756282T Active ES2920886T3 (es) 2015-02-25 2016-02-24 Agonistas de 5HT para el tratamiento de trastornos epilépticos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16756282T Active ES2920886T3 (es) 2015-02-25 2016-02-24 Agonistas de 5HT para el tratamiento de trastornos epilépticos

Country Status (21)

Country Link
US (5) US10874643B2 (enExample)
EP (4) EP3632434A1 (enExample)
JP (5) JP6884703B2 (enExample)
KR (3) KR102385665B1 (enExample)
CN (2) CN113546174A (enExample)
AU (3) AU2016222804C1 (enExample)
BR (1) BR112017018297B1 (enExample)
CA (2) CA2977135C (enExample)
CY (1) CY1125360T1 (enExample)
DK (1) DK3261640T3 (enExample)
EA (2) EA201992474A3 (enExample)
ES (2) ES3060954T3 (enExample)
HR (1) HRP20220822T1 (enExample)
HU (1) HUE059559T2 (enExample)
LT (1) LT3261640T (enExample)
PL (1) PL3261640T3 (enExample)
PT (1) PT3261640T (enExample)
RS (1) RS63426B1 (enExample)
SI (1) SI3261640T1 (enExample)
SM (1) SMT202200276T1 (enExample)
WO (1) WO2016138138A1 (enExample)

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Also Published As

Publication number Publication date
PT3261640T (pt) 2022-07-06
PL3261640T3 (pl) 2022-10-31
EP3261640A1 (en) 2018-01-03
HRP20220822T1 (hr) 2022-10-28
RS63426B1 (sr) 2022-08-31
US12447144B2 (en) 2025-10-21
EP4696377A3 (en) 2026-04-29
JP7846506B2 (ja) 2026-04-15
EP3261640A4 (en) 2018-12-19
CN107530326A (zh) 2018-01-02
EP4696377A2 (en) 2026-02-18
JP2022116307A (ja) 2022-08-09
ES2920886T3 (es) 2022-08-11
US11648237B2 (en) 2023-05-16
JP6884703B2 (ja) 2021-06-09
US20210154171A1 (en) 2021-05-27
EP4043016B1 (en) 2025-10-29
AU2021204261B2 (en) 2023-08-10
US20180028499A1 (en) 2018-02-01
US20200147048A1 (en) 2020-05-14
HUE059559T2 (hu) 2022-12-28
AU2021204261A1 (en) 2021-07-29
AU2016222804C1 (en) 2021-10-14
CA2977135C (en) 2023-08-22
EA201992474A3 (ru) 2020-05-31
WO2016138138A1 (en) 2016-09-01
SMT202200276T1 (it) 2022-09-14
KR20220048045A (ko) 2022-04-19
AU2022203274B2 (en) 2024-08-15
US20230346750A1 (en) 2023-11-02
US20260083706A1 (en) 2026-03-26
CA2977135A1 (en) 2016-09-01
EP3632434A1 (en) 2020-04-08
SI3261640T1 (sl) 2022-10-28
AU2022203274A1 (en) 2022-06-16
JP2021185148A (ja) 2021-12-09
CA3204599A1 (en) 2016-09-01
BR112017018297A2 (pt) 2018-04-17
EP3261640B1 (en) 2022-04-06
CN113546174A (zh) 2021-10-26
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