ES3060591T3 - Modified polymerases for improved incorporation of nucleotide analogues - Google Patents

Modified polymerases for improved incorporation of nucleotide analogues

Info

Publication number
ES3060591T3
ES3060591T3 ES20158427T ES20158427T ES3060591T3 ES 3060591 T3 ES3060591 T3 ES 3060591T3 ES 20158427 T ES20158427 T ES 20158427T ES 20158427 T ES20158427 T ES 20158427T ES 3060591 T3 ES3060591 T3 ES 3060591T3
Authority
ES
Spain
Prior art keywords
nucleotide analogues
modified polymerases
improved incorporation
incorporation
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20158427T
Other languages
English (en)
Spanish (es)
Inventor
Cheng-Yao Chen
Erin Bomati
Molly He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Illumina Inc
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of ES3060591T3 publication Critical patent/ES3060591T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
ES20158427T 2014-06-27 2015-06-25 Modified polymerases for improved incorporation of nucleotide analogues Active ES3060591T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462018470P 2014-06-27 2014-06-27

Publications (1)

Publication Number Publication Date
ES3060591T3 true ES3060591T3 (en) 2026-03-27

Family

ID=53716556

Family Applications (2)

Application Number Title Priority Date Filing Date
ES20158427T Active ES3060591T3 (en) 2014-06-27 2015-06-25 Modified polymerases for improved incorporation of nucleotide analogues
ES15739706T Active ES2788949T3 (es) 2014-06-27 2015-06-25 Polimerasas modificadas para la incorporación mejorada de análogos de nucleótidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15739706T Active ES2788949T3 (es) 2014-06-27 2015-06-25 Polimerasas modificadas para la incorporación mejorada de análogos de nucleótidos

Country Status (10)

Country Link
US (3) US9765309B2 (https=)
EP (2) EP3702471B1 (https=)
JP (3) JP6737710B2 (https=)
CN (1) CN106536728A (https=)
AU (2) AU2015279794B2 (https=)
DK (1) DK3161154T3 (https=)
ES (2) ES3060591T3 (https=)
PL (1) PL3161154T3 (https=)
PT (1) PT3161154T (https=)
WO (1) WO2015200693A1 (https=)

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WO2018126470A1 (zh) * 2017-01-09 2018-07-12 深圳华大智造科技有限公司 重组dna聚合酶
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CN108795900B (zh) * 2017-04-27 2021-02-02 深圳华大智造科技股份有限公司 Dna聚合酶及其制备方法
CN117802065A (zh) * 2018-09-03 2024-04-02 深圳华大生命科学研究院 聚合活性提高的重组型kod聚合酶
WO2020056044A1 (en) 2018-09-11 2020-03-19 Singular Genomics Systems, Inc. Modified archaeal family b polymerases
US11104888B2 (en) * 2018-10-31 2021-08-31 Illumina, Inc. Polymerases, compositions, and methods of use
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US11293061B2 (en) * 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11512295B2 (en) 2019-09-12 2022-11-29 Singular Genomics Systems, Inc. Modified thermoccocus polymerases
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US11591629B2 (en) * 2019-12-23 2023-02-28 Cheng-Yao Chen Method and kit for template-independent nucleic acid synthesis
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WO2021224677A1 (en) 2020-05-05 2021-11-11 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US20240392263A1 (en) * 2020-10-21 2024-11-28 Bgi Shenzhen Recombinant kod polymerase
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US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
TWI869710B (zh) * 2021-09-29 2025-01-11 呈堯 陳 用於無模板ｒｎａ合成的核酸聚合酶變體、試劑套組及方法
WO2024039652A1 (en) 2022-08-16 2024-02-22 Aldevron, L.L.C. Cell-free method of producing synthetic circular nucleic acid
US20240141427A1 (en) 2022-09-30 2024-05-02 Illumina, Inc. Polymerases, compositions, and methods of use
WO2024155578A1 (en) * 2023-01-16 2024-07-25 The Regents Of The University Of California Engineered polymerase for threose nucleic acid synthesis
CN116286720A (zh) * 2023-03-29 2023-06-23 赛纳生物科技(北京)有限公司 一种dna聚合酶
WO2025260380A1 (zh) * 2024-06-21 2025-12-26 华大工程生物学长荡湖研究所 重组型kod聚合酶

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Also Published As

Publication number Publication date
CA2951416A1 (en) 2015-12-30
AU2015279794A1 (en) 2016-12-22
PT3161154T (pt) 2020-06-08
US10870836B2 (en) 2020-12-22
EP3161154A1 (en) 2017-05-03
US9765309B2 (en) 2017-09-19
CN106536728A (zh) 2017-03-22
JP6737710B2 (ja) 2020-08-12
US20210246435A1 (en) 2021-08-12
AU2021290289A1 (en) 2022-01-27
EP3702471B1 (en) 2025-12-24
ES2788949T3 (es) 2020-10-23
JP2022033882A (ja) 2022-03-02
JP2020127415A (ja) 2020-08-27
JP2017518750A (ja) 2017-07-13
AU2021290289B2 (en) 2024-02-15
AU2015279794B2 (en) 2021-09-30
DK3161154T3 (da) 2020-06-15
EP3161154B1 (en) 2020-04-15
US12110514B2 (en) 2024-10-08
US20170355970A1 (en) 2017-12-14
US20150376582A1 (en) 2015-12-31
PL3161154T3 (pl) 2020-10-19
EP3702471A1 (en) 2020-09-02
EP3702471C0 (en) 2025-12-24
WO2015200693A1 (en) 2015-12-30
HK1231517A1 (en) 2017-12-22

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